Nanomaterials-based photothermal therapies for antibacterial applications

Liu, Fei; Xing, Fei; Zhou, Yuxi; Yu, Peiyun; Xu, Jiawei; Luo, Rong; Xiang, Zhou; Rommens, Pol Maria; Liu, Ming; Ritz, Ulrike

doi:10.1016/j.matdes.2023.112231

Cited by 53 publications

(21 citation statements)

References 499 publications

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“…These results demonstrated that the nanocomposite hydrogel was able to convert NIR light into thermal energy, in accordance with the typical photothermal behavior of its carbonaceous filler. Thermal images of H-polymer (Figure b) and H-MWCNT-f (Figure c) hydrogels illustrated the different evolution stages of the external temperature for both materials, confirming the photothermal response of the H-MWCNT-f sample under NIR light stimulus. , Similar results were reported by Dong et al, who observed a temperature increment of 15 °C for a composite hydrogel based on polycaprolactone (PCL)-poly(ethylene glycol)-PCL and MWCNT by NIR irradiation …”

Section: Results and Discussionsupporting

confidence: 87%

Nanocomposite Hydrogels Based on Poly(vinyl alcohol) and Carbon Nanotubes for NIR-Light Triggered Drug Delivery

García Verdugo,

Salazar Salas,

Chan

et al. 2024

ACS Omega

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Photothermal nanocomposite hydrogels are promising materials for remotely triggering drug delivery by nearinfrared (NIR) radiation stimuli. In this work, a novel hydrogel based on poly(vinyl alcohol), poly(vinyl methyl ether-alt-maleic acid), poly(vinyl methyl ether), and functionalized multiwalled carbon nanotubes (MWCNT-f) was prepared by the freeze/thaw method. A comparative characterization of materials (with and without MWCNT-f) was carried out by infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy, mechanical assays, swelling kinetics measurements, and photothermal analysis under NIR irradiation. Hydrophilic chemotherapeutic 5-fluorouracil (5-FU) and hydrophobic ibuprofen drugs were independently loaded into hydrogels, and the drug release profiles were obtained under passive and NIR-irradiation conditions. The concentration-dependent cytotoxicity of materials was studied in vitro using noncancerous cells and cancer cells. Notable changes in the microstructure and physicochemical properties of hydrogels were observed by adding a low content (0.2 wt %) of MWCNT-f. The cumulative release amounts of 5-FU and ibuprofen from the hydrogel containing MWCNT-f were significantly increased by 21 and 39%, respectively, through the application of short-term NIR irradiation pulses. Appropriate concentrations of the nanocomposite hydrogel loaded with 5-FU produced cytotoxicity in cancer cells without affecting noncancerous cells. The overall properties of the MWCNT-f-containing hydrogel and its photothermal behavior make it an attractive material to promote the release of hydrophilic and hydrophobic drugs, depending on the treatment requirements.

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Section: Results and Discussionsupporting

confidence: 87%

Nanocomposite Hydrogels Based on Poly(vinyl alcohol) and Carbon Nanotubes for NIR-Light Triggered Drug Delivery

García Verdugo,

Salazar Salas,

Chan

et al. 2024

ACS Omega

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“…In addition to their antibacterial properties, CB-2D-Ms have other advantages, such as biocompatibility, mechanical flexibility, and ease of functionalization. 26–29 These properties make CB-2D-Ms promising candidates for killing/inhibiting various bacterial strains, with prospects for effective use in different applications such as wound healing, medical implants, and water purification. Simultaneously, they are biocompatible and have shown a wide range of antibiotic properties, making them excellent candidates for use as antibacterial agents.…”

Section: Introductionmentioning

confidence: 99%

Carbon-based two-dimensional (2D) materials: a next generation biocidal agent

Talreja,

Chuahan,

Ashfaq

2024

Mater. Adv.

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“…In other words, the PDA@LA hydrogel caused only temporary thermal damage to healthy cells during NIR photothermal sterilization and did not cause sustained cytotoxicity to delay wound healing. Moreover, owing to the absence of specific targets and short action time of NIR photothermal sterilization, it is extremely difficult to induce bacterial resistance during the treatment of infected wounds. , …”

Section: Resultsmentioning

confidence: 99%

High-Density Dynamic Bonds Cross-Linked Hydrogel with Tissue Adhesion, Highly Efficient Self-Healing Behavior, and NIR Photothermal Antibacterial Ability as Dressing for Wound Repair

Lu,

Zhou,

Peng

et al. 2024

Biomacromolecules

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Multifunctional hydrogels with tissue adhesion, self-healing behavior, and antibacterial properties have potential in wound healing applications. However, their inefficient self-healing behavior and antibacterial agents can cause long-term cytotoxicity and drug resistance, considerably limiting their clinical use. Herein, we reported a PDA@LA hydrogel constructed by introducing polydopamine nanoparticles (PDA-NPs) into a high-density dynamic bonds cross-linked lipoic acid (LA) hydrogel that was formed by the polymerization of LA. Because of its rich carboxyl groups, the LA hydrogel could adhere firmly to various tissues. Owing to the high-density dynamic bonds, the cut LA hydrogel exhibited highly inefficient self-healing behavior and recovered to its uncut state after self-healing for 10 min. After the introduction of the PDA-NPs, the hydrogel was able to heat up to more than 40 °C to kill approximately 100% of the Escherichia coli and Staphylococcus aureus under near-infrared (NIR) laser, thus resisting wound infections. Because no toxic antibacterial agent was used, the PDA@LA hydrogel caused mild long-term cytotoxicity or drug resistance. Consequently, the adhesive, highly efficient self-healing, and NIR photothermal antibacterial PDA@LA hydrogel exhibits considerable potential for clinical use.

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Nanomaterials-based photothermal therapies for antibacterial applications

Cited by 53 publications

References 499 publications

Nanocomposite Hydrogels Based on Poly(vinyl alcohol) and Carbon Nanotubes for NIR-Light Triggered Drug Delivery

Nanocomposite Hydrogels Based on Poly(vinyl alcohol) and Carbon Nanotubes for NIR-Light Triggered Drug Delivery

Carbon-based two-dimensional (2D) materials: a next generation biocidal agent

High-Density Dynamic Bonds Cross-Linked Hydrogel with Tissue Adhesion, Highly Efficient Self-Healing Behavior, and NIR Photothermal Antibacterial Ability as Dressing for Wound Repair

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