5th/6th generation bio-sensing technology is an emerging field requiring connection with efficient nano-enabled sensing platforms optimized for point-of-care testing to investigate health management strategies. Recently, the integration and interfacing between quantum measurement, signalling, and optimized bio-actives has led to investigation of minute biological events with anomalous sensitivity. Such quantum biosensing is expected to provide the possibility to measure or record phenomena at those scales with pressure, temperature, and electromagnetic fields. Considering current scenarios, this perspective highlights state-of-the-art quantum sensing technology along with challenges and prospects.