Nanomaterials for Wound Healing and Infection Control

Abstract

Wound healing has been intensely studied in order to develop an “ideal” technique that achieves expeditious recovery and reduces scarring to the minimum, thus ensuring function preservation. The classic approach to wound management is represented by topical treatments, such as antibacterial or colloidal agents, in order to prevent infection and promote a proper wound-healing process. Nanotechnology studies submicroscopic particles (maximum diameter of 100 nm), as well as correlated phenomena. Metal nanoparticles (e.g., silver, gold, zinc) are increasingly being used in dermatology, due to their beneficial effect on accelerating wound healing, as well as treating and preventing bacterial infections. Other benefits include: ease of use, less frequent dressing changes and a constantly moist wound environment. This review highlights recent findings regarding nanoparticle application in wound management.

Porous Poly(Hexamethylene Biguanide) Hydrochloride Loaded Silk Fibroin Sponges with Antibacterial Function

“…It is difficult for systemically applied antibiotics to reach wounds because of poor blood circulation. The application of local antibiotics is the main method used to prevent wound infection [33]. The effective strategy is to load the antibacterial drugs into the wound dressing and release it slowly to the wound to achieve a long-lasting local antibacterial effect.…”

Acute Myocardial Infarction Mortality Rates and Trends in Romania between 1994 and 2017

“…In a recent report from the American Heart Association, the incidence and mortality from ischemic heart disease was reported to be approximately 10-20 years lagging in women as compared with men [14]. Hypertension, dyslipidemia [15], smoking, obesity, and diabetes [16,17] are major cardiovascular risk factors, commonly found among adult Romanian population. Hypertension prevalence in Romania reported by the SEPHAR III study was 45.1%, increasing from 40% in the previous report [18,19].…”

Emerging Priorities for Microbiome Research

“…Additionally, silver nanoparticles derived from the fungus Piriformospora indica showed increased cytotoxic effects against human breast adenocarcinoma (MCF-7) followed by human cervical carcinoma (HeLa) and human liver hepatocellular carcinoma (HepG2) cell lines as compared to chemically synthesized silver nanoparticles (Aziz et al, 2019). Silver nanoparticles have been also used in wound dressings and coatings for consumer products and biomedical devices (Marassi et al, 2018;Mihai et al, 2019).…”