Nanomaterials for Wound Healing: Scope and Advancement

Kalashnikova, Irina; Das, Soumen; Seal, Sudipta

doi:10.2217/nnm.15.82

Cited by 184 publications

(135 citation statements)

References 105 publications

(120 reference statements)

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“…There are two main categories of nanomaterials used in wound healing: (1) nanomaterials that exhibit intrinsic properties beneficial for wound treatment and (2) nanomaterials employed as delivery vehicles for therapeutic agents. 20,34 …”

Section: Nanotechnology In Wound Healingmentioning

confidence: 99%

“…12,18,19 Better understanding of the wound-healing process has also contributed to the emergence of contemporary dressing-based therapies (Table 1). 20,21 Thus, modern dressings were custom designed to provide the beneficial microenvironment for successful healing by controlling wound moisture and absorbing excess exudate. 22 Active dressings may locally alter the wound’s biochemical environment by targeting bacterial load and excessive protease levels, or providing exogenous collagen matrices which serve as a scaffold for tissue ingrowth when endogenous collagen is disrupted by the proteolytic wound environment (Table 1).…”

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confidence: 99%

“…32,33 The major advantage of nanomaterials over their bulk counterparts is the versatility and tunability of the nanomaterial’s physicochemical properties (e.g., hydrophobicity, charge, size). 20 Furthermore, the high surface area to volume ratio endows nanostructures with unique features. 32 For example, nanoscale particles provide for a high probability of interaction with the biological target and an enhanced penetration into the wound site.…”

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confidence: 99%

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Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications

et al. 2017

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The chronic nature and associated complications of nonhealing wounds have led to the emergence of nanotechnology-based therapies that aim at facilitating the healing process and ultimately repairing the injured tissue. A number of engineered nanotechnologies have been proposed demonstrating unique properties and multiple functions that address specific problems associated with wound repair mechanisms. In this outlook, we highlight the most recently developed nanotechnology-based therapeutic agents and assess the viability and efficacy of each treatment, with emphasis on chronic cutaneous wounds. Herein we explore the unmet needs and future directions of current technologies, while discussing promising strategies that can advance the wound-healing field.

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Section: Nanotechnology In Wound Healingmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications

et al. 2017

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“…The hostile environment of the wound comprising degradative enzymes and elevated pH, as well as the complexity of physiological processes, requires an effective advanced drug delivery system as a wound dressing [1,2]. An ideal wound dressing should reduce infection, moisturize the wound, stimulate the healing mechanism, accelerate the wound closure, and reduce/control scar formation [3].…”

Section: Introductionmentioning

confidence: 99%

Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing

et al. 2019

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A liposomes-in-hydrogel system as an advanced wound dressing for dermal delivery of curcumin was proposed for improved chronic wound therapy. Curcumin, a multitargeting poorly soluble active substance with known beneficial properties for improved wound healing, was incorporated in deformable liposomes to overcome its poor solubility. Chitosan hydrogel served as a vehicle providing superior wound healing properties. The novel system should assure sustained skin delivery of curcumin, and increase its retention at the skin site, utilizing both curcumin and chitosan to improve the therapy outcome. To optimize the properties of the formulation and determine the effect of the liposomal charge on the hydrogel properties, curcumin-containing deformable liposomes (DLs) with neutral (NDLs), cationic (CDLs), and anionic (ADLs) surface properties were incorporated in chitosan hydrogel. The charged DLs affected the hydrogel's hardness, cohesiveness, and adhesiveness. Importantly, the incorporation of DLs, regardless of their surface charge, in chitosan hydrogel did not decrease the system's bioadhesion to human skin. Stability testing revealed that the incorporation of CDLs in hydrogel preserved hydrogel´s bioadhesiveness to a higher degree than both NDLs and ADLs. In addition, CDLs-in-hydrogel enabled the most sustained skin penetration of curcumin. The proposed formulation should be further evaluated in a chronic wound model.Curcumin has been proposed as one of the most promising [5]. Moreover, curcumin is a molecule able to active multiple pathways, contributing to improved wound healing [6]. The antioxidant, anti-inflammatory, and anti-bacterial properties of this pleiotropic molecule need to be more utilized [7,8]. Although curcumin is a very promising molecule to be included in wound dressings, its hydrophobicity, extensive metabolism, and limited skin penetration often hamper its wider use [9]. We have recently proven that curcumin, a multitargeting active substance, exhibits superior anti-inflammatory properties when incorporated in tailored deformable liposomes [10]. In this work, we went a step further in the development of curcumin-based wound dressings and combined the beneficial properties of curcumin as an active moiety and chitosan hydrogel as a superior vehicle to form a bioactive wound dressing targeting the treatment of chronic wounds.An ideal dressing should assure an enhanced therapeutic outcome and reduction of pain accompanied with wound dressing changes [11]. Among the possible material to be used in the manufacturing of bioactive dressings, natural polymer-based wound dressings, such as hydrogels, represent promising advanced delivery systems with a low risk of toxicity and side effects due to their biodegradability and biocompatibility [12,13]. Hydrogels mimic the biochemical, biomechanical, and structural features of the extracellular matrix (ECM), serving as superior matrices for wound treatment [13,14]. Hydrogels additionally possess good bioadhesiveness that can contribute to a prolonged retention...

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“…In the recent past, nanotechnology-based therapy has significantly revolutionized the management of wound care and also recognized as possible next-generation therapy. To date, a wide range of nanomaterials composed of carbon, lipid, ceramic, metal, and metal oxide nanoparticles have been reported for their beneficial role in wound healing [11]. Electrospun nanofibers have received tremendous attention toward energy, environmental, and biomedical applications due to their exceptional characteristic features [12][13][14][15][16].…”

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confidence: 99%