Nanomaterials in Consumer Products

Hansen, Steffen Foss; Baun, Anders; Michelson, Evan S.; Kamper, Anja; Borling, Pernille; Stuer‐Lauridsen, Frank

doi:10.1007/978-1-4020-9491-0_28

Cited by 14 publications

(6 citation statements)

References 2 publications

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“…All of this makes NM attractive for different areas ranging from industry and pharmaceutical applications to environmental remediation and biomedicine. Until now, more than 1600 globally available consumer products use manufactured NM (nanotechproject.org), and predictions suggest that these nano-based products will increase dramatically in the next years (Fairbrother, 2010; Hansen et al, 2009). Hence, the current human and environmental exposure to NM will inevitably increase in the near future (Buzea et al, 2007; Savolainen et al, 2010), requiring more data on their potential secondary effects.…”

Section: Introductionmentioning

confidence: 99%

Genotoxic and oxidative stress potential of nanosized and bulk zinc oxide particles in Drosophila melanogaster

Carmona

Inostroza‐Blancheteau

Rubio

et al. 2016

Toxicol Ind Health

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Zinc oxide nanoparticles (ZnONP) are manufactured on a large scale and can be found in a variety of consumer products, such as sunscreens, lotions, paints and food additives. Few studies have been carried out on its genotoxic potential and related mechanisms in whole organisms. In the present study, the in vivo genotoxic activity of ZnONP and its bulk form was assayed using the wing-spot test and comet assay in Drosophila melanogaster Additionally, a lipid peroxidation analysis using the thiobarbituric acid assay was also performed. Results obtained with the wing-spot test showed a lack of genotoxic activity of both ZnO forms. However, when both particle sizes were tested in the comet assay using larvae haemocytes, a significant increase in DNA damage was observed for ZnONP treatments but only at the higher dose applied. In addition, the lipid peroxidation assay showed significant malondialdehyde (MDA) induction for both ZnO forms, but the induction of MDA for ZnONP was higher for the ZnO bulk, suggesting that the observed DNA strand breaks could be induced by mediated oxidative stress. The overall data suggest that the potential genotoxicity of ZnONP in Drosophila can be considered weak according to the lack of mutagenic and recombinogenic effects and the induction of primary DNA damage only at high toxic doses of ZnONP. This study is the first assessing the genotoxic and oxidative stress potential of nano and bulk ZnO particles in Drosophila.

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Section: Introductionmentioning

confidence: 99%

Genotoxic and oxidative stress potential of nanosized and bulk zinc oxide particles in Drosophila melanogaster

Carmona

Inostroza‐Blancheteau

Rubio

et al. 2016

Toxicol Ind Health

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“…This element has been used since ancient times for jewellers, utensils, monetary currency, dental alloy, photography, explosives (Oberdörster, 2010). These characteristics mainly attributed to increase the surface area to volume ratio, which potentially results in high reactivity (Hansen et al, 2008). Silver nanoparticles have been used as nonmaterial's most frequently in consumer products because of antimicrobial properties (Hansen et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…These characteristics mainly attributed to increase the surface area to volume ratio, which potentially results in high reactivity (Hansen et al, 2008). Silver nanoparticles have been used as nonmaterial's most frequently in consumer products because of antimicrobial properties (Hansen et al 2008). Silver in the form of Ag + ions has toxic effects on many pathogens, including bacteria, viruses, and fungi (Lok et al 2007).…”

Section: Introductionmentioning

confidence: 99%

The effect of dietary silver nanoparticles on performance, immune organs, and lipid serum of broiler chickens during starter period

2013

Int. J. Biosci.

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This research was carried out to investigate the effect of silver nanoparticles (SNPs) on growth performance, immune organs, and serum lipids of broilers from 1 to 21 days of age. A total of 240 one-day-male broilers (Ross 308) distributed in four groups of 60 birds, including 4 replicates and 15 birds in each pen. Birds were fed on experimental diets including: T1 (control) without SNPs, T2, T3 and T4 supplementation basal diet with 4, 8 or 12 mg SNPs per kg of diet, respectively. At 21 d about 5 ml bloods (4 birds per groups) was removed from bronchial vein of four birds per replicate. Serum removed by centrifuged and stored at -20°C till the start of analysis. After blood sampling, birds were slaughtered and then visceral organs removed. Although the weight of selected organs was calculated regarding the total live body weight of each birds. The results indicated that SNPs have no significant effects on the performance (P≥0.05), there is a relative increased weight in SI and liver compared to control group (P≤0.05). Considering the abort points, the bursa weight was decreased compared to control treatment (P≤0.05). In addition TG, LDL, VLDL, and uric acid increased significantly (P≤0.05) in all treated than the control, as well as, HDL had significantly (P≤0.05) decreased compared with control. Relative weight of bursa Fabricius decreased (P≤0.05) in birds fed supplementation diet with levels of SNPs compared with control, especially in T4 birds. In conclusion, the SNPS no suitable alternatives as growth performance, Therefore, because of the mention changes may lead to negative effect on performance, immune response and health of broiler chickens.

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“…For nanotoxicity study, it has been accepted that nanoparticle-aggregates also can provide stable suspensions for a relatively correct dose. Additionally, TiO2 nanoparticles form aggregates in sunscreen formulations as well [8,10]. Therefore, it is biologically relevant to observe toxicity caused by TiO2 aggregates in the interaction with skin keratinocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Firstly, the precise dose range of these nanoparticles used in the formulation of commercial sunscreens is unknown. There is a lack of information on the concentration and physico-chemical properties of nanoparticles used in cosmetic products as well as on market fractions of nanoparticle-containing products [8,9]. Little information has been revealed to the public and the dose range of nanoparticles used in sunscreens may remain as trade secrets.…”

Section: Research Backgroundmentioning

confidence: 99%

Titanium dioxide and zinc oxide nanoparticles induce autophagy associated with toxicity effects in primary human keratinocytes : a dose relevance study

Zhao¹

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for their support of part of the experimental equipment and materials used, their help, and the fruitful discussions we had. Next, I record my thanks to my colleagues in both Dr. Ng and Dr. Loo's groups, who collegially provided logistical support for my research; and also members of Dr. Wong's group for their help in part of my work. I am grateful to School of Materials Science and Engineering and the Ian Ferguson Postgraduate Fellowship for their financial support of my overseas study at Karolinska Institutet. Last but not least, I am thankful to my parents, my husband, and my parents-in-law for their encouragement and moral support over the course of my PhD study.

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Nanomaterials in Consumer Products

Cited by 14 publications

References 2 publications

Genotoxic and oxidative stress potential of nanosized and bulk zinc oxide particles in Drosophila melanogaster

Genotoxic and oxidative stress potential of nanosized and bulk zinc oxide particles in Drosophila melanogaster

The effect of dietary silver nanoparticles on performance, immune organs, and lipid serum of broiler chickens during starter period

Titanium dioxide and zinc oxide nanoparticles induce autophagy associated with toxicity effects in primary human keratinocytes : a dose relevance study

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