Nanomaterials in nutraceutical and phytonutrient industries

Amalraj, Augustine; Jude, Shintu; Sukumaran, Nimisha Pulikkal; Gopi, Sreeraj

doi:10.1016/b978-0-12-815749-7.00016-5

Cited by 5 publications

(2 citation statements)

References 142 publications

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“…The solvent evaporation method can quickly dry a liquid or slurry to a powdery state by atomizing active ingredients within liquid solution 27 . In this process, the thermal energy breaks the long‐range crystal lattices of incorporated drug molecules, which is converted to a liquid state at the melting point ( T m ).…”

Section: Resultsmentioning

confidence: 99%

“…The solvent evaporation method can quickly dry a liquid or slurry to a powdery state by atomizing active ingredients within liquid solution. 27 In this process, the thermal energy breaks the long-range crystal lattices of incorporated drug molecules, which is converted to a liquid state at the melting point (T m ). By rapid cooling process, amorphous SD is formed 28 and the crystalline drug powder becomes amorphous and this process can be better elucidated by following Equation (1): 15…”

Section: Thermodynamic Considerationsmentioning

confidence: 99%

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Polymeric solid dispersion enhances the equilibrium solubility and oral bioavailability of tegoprazan

Won

Yang²,

Hong

et al. 2023

Bulletin Korean Chem Soc

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The recently developed water‐insoluble tegoprazan (TPZ) belongs to the biopharmaceutical classification system (BCS) class II group was formulated through solid dispersion (SD) technology. SD formulations of TPZ were prepared using hydroxymethylcellulose (HPMC) and polyvinylpyrrolidone (PVP) polymers via the solvent evaporation method. SDs were characterized by scanning electron microscopy (SEM), powder x‐ray diffraction (PXRD), and differential scanning calorimetry (DSC). In addition, the equilibrium solubility of SDs, in vitro dissolution, and in vivo bioavailability (BA) study in rats were performed. PXRD and DSC revealed that TPZ was successfully transformed to amorphous forms in SDs. The equilibrium solubility was enhanced by 15–18‐fold, and in vitro dissolution was improved by approximately 2.2‐fold. Consequently, the BA of TPZ was increased up to 2.1‐fold. In conclusion, the use of SDs of TPZ using HPMC and PVP are considered a potential strategy to improve the therapeutic effect of TPZ via enhanced dissolution and BA.

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Section: Resultsmentioning

confidence: 99%