Nanomaterials modulating stem cell behavior towards cardiovascular cell lineage

Arzaghi, Hamidreza; Rahimi, Bahareh; Adel, Bashir; Rahimi, Golbarg; Taherian, Zahra; Sanati, Afsaneh L.; Dezfuli, Amin Shiralizadeh

doi:10.1039/d0ma00957a

Cited by 28 publications

(14 citation statements)

References 266 publications

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“…In this sense, nanomaterials are an excellent choice for increasing the efficiency of various engineering systems [25][26][27][28][29][30][31]. They can offer undiscovered unique properties for the systems under study [32][33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Voltammetric carbon nanotubes based sensor for determination of tryptophan in the milk sample

et al. 2021

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In this research, functionalized carbon nanotubes were employed to modify a glassy carbon electrode (F-MWCNT/GCE). Several techniques including Fourier Transform Infrared Spectroscopy, scanning electron microscopy, and transmission electron microscopy were utilized for characterization of F-MWCNT. The electrochemical activity of the developed electrode was assessed by differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectroscopy. The electrochemical results demonstrated that oxidation of tryptophan (TRP) caused a higher anodic peak current than unmodified GCE. The F-MWCNT/GCE offered a detection limit of 3.63 nM and dynamic ranges of 0.01-0.7 µM for analysis of TRP by the differential pulse voltammetry method. Moreover, tryptophan detection was achieved successfully using F-MWCNT/ GCE in milk samples. It can be stated that this method paves the way for a selective, sensitive and straightforward method to determine tryptophan in the real food sample.

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Section: Introductionmentioning

confidence: 99%

Voltammetric carbon nanotubes based sensor for determination of tryptophan in the milk sample

et al. 2021

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“…Graphene has an overabundance of potential applications in various fields of interest, including optoelectronics, photonics, medicine, and so on [46,47]. For instance, nonlinear optical materials have been widely exploited towards the protection of sensitive instruments from laser-induced damage [48], to increase the performance in water treatment technologies [49], to form functional coatings (e.g., graphene coated plastic materials which are used to improve shelf life in medical firms and to increase resistance against corrosive acids) [50], to improve conductivity in rechargeable batteries [51], to prepare lenses with improved microscopic refractive indices by reducing the thickness of the lens [52], and to store hydrogen for medical purposes [53].…”

Section: Graphene and Graphene Oxidementioning

confidence: 99%

Impact of Graphene Derivatives as Artificial Extracellular Matrices on Mesenchymal Stem Cells

et al. 2022

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Thanks to stem cells’ capability to differentiate into multiple cell types, damaged human tissues and organs can be rapidly well-repaired. Therefore, their applicability in the emerging field of regenerative medicine can be further expanded, serving as a promising multifunctional tool for tissue engineering, treatments for various diseases, and other biomedical applications as well. However, the differentiation and survival of the stem cells into specific lineages is crucial to be exclusively controlled. In this frame, growth factors and chemical agents are utilized to stimulate and adjust proliferation and differentiation of the stem cells, although challenges related with degradation, side effects, and high cost should be overcome. Owing to their unique physicochemical and biological properties, graphene-based nanomaterials have been widely used as scaffolds to manipulate stem cell growth and differentiation potential. Herein, we provide the most recent research progress in mesenchymal stem cells (MSCs) growth, differentiation and function utilizing graphene derivatives as extracellular scaffolds. The interaction of graphene derivatives in human and rat MSCs has been also evaluated. Graphene-based nanomaterials are biocompatible, exhibiting a great potential applicability in stem-cell-mediated regenerative medicine as they may promote the behaviour control of the stem cells. Finally, the challenges, prospects and future trends in the field are discussed.

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“…Researchers are exploring multidimensional nanomaterials to manipulate the fate and transport of stem cells. 19 − 21 Due to the small size of nanomaterials, their surface can be modified to imitate the biophysical cues provided by extracellular matrix (ECM). 22 − 24 Owing to their high surface area to volume ratio, they can be easily used for targeted drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Carbon Quantum Dots for Stem Cell Imaging and Deciding the Fate of Stem Cell Differentiation

et al. 2022

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Nanotechnology advancements and applications have paved the way for new possibilities in regenerative medicine and tissue engineering. It is a relatively new field that has the potential to improve stem cell differentiation and therapy greatly. Numerous studies have demonstrated that nanomaterials can function as a physiological niche for the formation and differentiation of stem cells. However, quantum dots (QDs), such as carbon quantum dots (CQDs) and graphene quantum dots (GQDs), have shown considerable promise in the field of regenerative medicine. To date, most research has focused on stem cell tracking and imaging using CQDs. However, their interaction with stem cells and the associated possibility for differentiation by selectively focusing chemical signals to a particular lineage has received scant attention. In this mini-review, we attempt to categorize a few pathways linked with the role of CQDs in stem cell differentiation.

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Nanomaterials modulating stem cell behavior towards cardiovascular cell lineage

Abstract: The cardiovascular system, which is one of the complex and indispensable systems in the body, is responsible for the circulation of nutrition, oxygen, carbon dioxide, hormones to other parts of...

Cited by 28 publications

References 266 publications

Voltammetric carbon nanotubes based sensor for determination of tryptophan in the milk sample

Voltammetric carbon nanotubes based sensor for determination of tryptophan in the milk sample

Impact of Graphene Derivatives as Artificial Extracellular Matrices on Mesenchymal Stem Cells

Carbon Quantum Dots for Stem Cell Imaging and Deciding the Fate of Stem Cell Differentiation

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