Nanomaterials to avoid and destroy protein aggregates

Abstract

Aggregation of proteins is involved in many disorders. Besides amyloid fibrils, which mostly form in the brain, other kind of protein aggregates can lead, for example, to clots in the blood or floaters in the vitreous of the eye. This review is not only limited to amyloid diseases but aims at giving the reader a general overview on how nanomaterials can be employed to avoid and destroy protein aggregates of different nature. Thanks to their recognized versatility, nanomaterials may offer attractive features against harmful protein aggregates. In addition to their known ability to interact with proteins, we also aim at providing a state-of-the-art on how stimuli-responsive nanomaterials can be employed to destroy aggregates. Despite promising and conceptually interesting strategies on how nanomaterials can lead to the destruction of protein aggregates and the prevention of their formation, it appears clearly that many efforts still remain, however, to demonstrate in vivo feasibility and safety to pave the way for clinically relevant therapies.

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters

“…Note that physiochemical properties of nanoparticles such as size and surface charge, have been considered as critical factors for their antifibrotic properties. 48,49 (a)…”

Bubble Forming Films for Spatial Selective Cell Killing

“…In recent years, the potential of the mechanical forces which arise from such collapsing VNBs has been investigated by us and others i) to porate cell membranes (photoporation) and deliver cargos of different nature in the cells, [ 18–24 ] ii) to improve the diffusion of antibiotics in bacterial biofilms, [ 25 ] and iii) to destroy harmful protein aggregates, such as eye floaters which form in the vitreous humor upon ageing. [ 26,27 ]…”

Pd-Au Alaşımında Au Atomunun Konsantrasyonunun Polyhedron Topakları Oluşumu Üzerine Etkisinin Moleküler Dinamik Yöntemle İncelenmesi

“…Özellikle; basınç, ısıtma/soğutma hızı ve alaşımların konsantrasyon oranı gibi bazı dış şartların malzemelerin faz geçişi süreci üzerine etkileri son zamanlarda yapılan çalışmalarda görülmektedir [8]. Bununla birlikte, Pd elementine Au eklenmesiyle oluşan ikili alaşımda hızlı soğutma sürecinde meydana gelen amorf fazın oluşum mekanizması hakkında bilgiler oldukça kısıtlıdır [9,10].…”