Nanomechanical Recognition and Discrimination of Volatile Molecules by Au Nanocages Deposited on Membrane-Type Surface Stress Sensors

Osica, Izabela; Melo, Antonio F. A. A.; Lima, Filipe Camargo Dalmatti Alves; Shiba, Kota; Imamura, Gaku; Crespilho, Frank N.; Betlej, Jan; Kurzydowski, Krzysztof J.; Yoshikawa, Genki; Ariga, Katsuhiko

doi:10.1021/acsanm.0c00115

Cited by 13 publications

(10 citation statements)

References 44 publications

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“…MXene was consequently selected as the conductive layer material for the MHBios. The MHBios’ resistance modifies with the deformation of the MXene membrane. ,, Surface stress was produced by the specific binding of anti-HSA and HSA to the sensitive layer. Surface tension caused the MXene membrane’s structure to alter, which changed the conductive route through the membrane. , Additionally, the magnetic nanoparticles move on the MHBios surface under the influence of a uniform magnetic field as a result of magnetic Fe 3 O 4 sensitization.…”

Section: Resultsmentioning

confidence: 99%

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Multilayer Heterogeneous Membrane Biosensor Based on Multiphysical Field Coupling for Human Serum Albumin Detection

et al. 2023

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A factor closely associated with renal disease status in clinical diagnosis is abnormal human serum albumin (HSA) concentration levels in human body fluids urine, serum, etc. The surface stress biosensor was developed as a new type of biosensor to detect protein molecule concentration and has a wide range of clinical applications. However, further sensitivity improvement is required to achieve higher detection performance. Herein, MXene/PDMS/ Fe 3 O 4 /PDMS of the multilayer heterogeneous membrane biosensor (MHBios) based on the coupling of the magnetic field, electric field, and surface stress field was successfully developed to achieve high sensitivity HSA detection through magnetic sensitization. The modified antibody specifically binds to HSA at the AuNP layer, allowing the biosensor to convert the surface stress caused by PDMS film deformation into an electrical signal. When the biosensor was exposed to a uniform magnetic field, the conductive path of the conductive layer was reshaped further as the magnetic force amplified the deformation of the PDMS film, enhancing the conversion of biological signals to electrical signals. The results exhibited that the detection limit (LOD) of the MHBios was 78 ng/mL when HSA concentration was 0−50 μg/ mL, which was markedly lower than the minimum diagnostic limit of microalbuminuria. Furthermore, the MHBios detected HSA in actual samples, confirming the potential for early disease screening.

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Section: Resultsmentioning

confidence: 99%

“… 16 However, for the purpose of improving the performance of detecting higher single molecules, the sensitivity of the MBios needed to be further improved. 16 , 17 …”

Section: Introductionmentioning

confidence: 99%

Multilayer Heterogeneous Membrane Biosensor Based on Multiphysical Field Coupling for Human Serum Albumin Detection

et al. 2023

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“…These applications need a database of membrane shape corresponding to several kinds of drinks. Recently, measurement of membrane response through transduction of mechanical stresses detected several solvents, such as water alcohols (i.e., methanol, ethanol, and 2-propanol), acetone, ethyl acetate, alkanes (i.e., n -hexane and n -heptane), and aromatics (i.e., benzene and toluene). , They reported that membranes are used to detect molecular mass through molecular mass analysis . Membrane response patterns have the potential to be used as a sensor.…”

Section: Resultsmentioning

confidence: 99%

Quality Evaluation of Drinks Based on Liposome Shape Changes Induced by Flavor Molecules

Yoda

2022

ACS Omega

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The flavors of ethyl caproate and isoamyl acetate and their precursors are crucial in sake brewing for fermentation and evaluation of the corresponding quality of drinks. However, the quality evaluation of drinks containing these flavors is challenging. Therefore, sake quality was evaluated via dynamic membrane transformation on cell-sized liposomes while adding flavor-containing solutions. Flavor varieties have been reported to influence dynamic shape change patterns. This study reports the observed difference in the dynamic shape change of each flavor. Based on these results, proper quality evaluation of drinks is expected.

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“…Another advanced application of colloidal PGNs is sensor technology. Porous cubical Au nanoparticles were successfully utilized as receptor materials for membrane-type surface stress sensors [41].…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Stabilization of Support-Free Mesoporous Gold Nanoparticles

et al. 2020

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Porous gold nanoparticles (PGNs) are usually prepared in an immobilized form on a solid substrate, which is not practical in many applications. In this work, a simple method is reported for the preparation and stabilization of mesoporous gold particles of a few hundred nanometers in size in aqueous suspension. Nanoparticles of Ag-Au alloy were fabricated on CaF 2 and Si/SiO 2 substrates by the solid-state dewetting method. Silver was selectively dissolved (dealloyed), and the resulting porous gold nanoparticles were chemically removed from the substrate either in a concerted step with dealloying, or in a subsequent step. Nitric acid was used for the one-step dealloying and detachment of the particles from CaF 2 substrate. The consecutive use of HNO 3 and HF resulted in the dealloying and the subsequent detachment of the particles from Si/SiO 2 substrate. The PGNs were recovered from the aqueous suspensions by centrifugation. The Au content of the suspensions was monitored by using elemental analysis (ICP-OES), and recovery was optimized. The morphology and the optical characteristics of the support-free PGNs were analyzed by scanning electron microscopy (SEM), dynamic light scattering spectroscopy (DLS), and near-infrared spectrophotometry (NIR). The obtained PGNs are spherical disk-shaped with a mean particle size of 765 ± 149 nm. The suspended, support-free PGNs display an ideally narrow dipole plasmon peak at around 1450 nm in the NIR spectral region. Thus, the new colloidal PGNs are ideal candidates for biomedical applications, for instance photothermal therapy.

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Nanomechanical Recognition and Discrimination of Volatile Molecules by Au Nanocages Deposited on Membrane-Type Surface Stress Sensors

Cited by 13 publications

References 44 publications

Multilayer Heterogeneous Membrane Biosensor Based on Multiphysical Field Coupling for Human Serum Albumin Detection

Multilayer Heterogeneous Membrane Biosensor Based on Multiphysical Field Coupling for Human Serum Albumin Detection

Quality Evaluation of Drinks Based on Liposome Shape Changes Induced by Flavor Molecules

Synthesis and Stabilization of Support-Free Mesoporous Gold Nanoparticles

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