Nanomedicine and drug delivery: a mini review

Mirza, Agha Zeeshan; Siddiqui, Farhan Ahmed

doi:10.1007/s40089-014-0094-7

Cited by 287 publications

(130 citation statements)

References 77 publications

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“…Multifunctional nanovectors represent innovative methods for therapy administration and are fundamental to overcoming the relevant issues associated with conventional chemotherapy, including low tumor accumulation and signicant toxicity of drugs. [1][2][3][4][5][6][7][8][9][10] The in vivo potential efficacy of a nanosystem, specically designed for the treatment of a dened type of cancer, needs to be preliminarily assessed by means of a comprehensive in vitro investigation. In vitro high magnication imaging study represents an essential step to achieve a comprehensive understanding of the effect on the cell structure of the new organic and/or inorganic nanoformulations, that are proposed as innovative drug delivery systems and of their pharmacological activity.…”

Section: Introductionmentioning

confidence: 99%

Imaging modification of colon carcinoma cells exposed to lipid based nanovectors for drug delivery: a scanning electron microscopy investigation

et al. 2019

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The adsorption at cell surfaces and cell internalization of two drug delivery lipid based nanovectors has been investigated by means of Field Emission Scanning Electron Microscopy (FE-SEM) operating at low beam voltage on two different colon carcinoma cell lines, CaCo-2 and CoLo-205, that were compared with the M14 melanoma cell line, as a reference. The cells were incubated with the investigated multifunctional nanovectors, based on liposomes and magnetic micelles loaded with 5-fluorouracil, as a chemotherapeutic agent, and a FE-SEM systematic investigation was performed, enabling a detailed imaging of any morphological changes of the drug exposed cells as a function of time. The results of the FE-SEM investigation were validated by MTS assay and immunofluorescence staining of the Ki-67 protein performed on the investigated cell lines at different times. The two nanoformulations resulted in a comparable effect on CaCo-2 and M14 cell lines, while for CoLo 205 cells, the liposomes provided an cytotoxic activity higher than that observed in the case of the micelles. The study highlighted the high potential of FE-SEM as a valuable complementary technique for imaging and monitoring in time the drug effects on the selected cells exposed to the two different nanoformulations. † Electronic supplementary information (ESI) available: FE-SEM analysis performed on the three different cell lines, aer their incubation with free 5-FU for 24 and 48 hours. See Fig. 9 Representative FE-SEM micrographs (EHT ¼ 3.00 kV) and their corresponding close-up details, at higher magnification, of CoLo-205 (a and a 1 ) cells after 48 hours treatment with SPION/5-FU/Micelles, CaCo-2 (b and b 1 ) cells after 48 hours treatment with 5-FU/Liposomes, and M-14 (c, c 1 and d, d 1 ) cells after 48 hours treatment with SPION/5-FU/Micelles and 5-FU/Liposomes, respectively.21818 | RSC Adv., 2019,9,[21810][21811][21812][21813][21814][21815][21816][21817][21818][21819][21820][21821][21822][21823][21824][21825] This journal is

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Section: Introductionmentioning

confidence: 99%

Imaging modification of colon carcinoma cells exposed to lipid based nanovectors for drug delivery: a scanning electron microscopy investigation

et al. 2019

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“…The introduction of advanced nanotechnology in the medical field aimed to better prevention, diagnostics and therapy of diseases, is called nanomedicine [41]. Incorporating therapeutic drugs with nano-objects (NOs) showed promising results in avoiding systemic side effects of drugs by improving its precision in targeting at the cellular level [42,43]. Most of the NOs are objects with a spherical shape but all the NOs are with nanometric size (most often below 200 nm) [44].…”

Section: Nanomedicine Applications For Cancer Immunotherapymentioning

confidence: 99%

Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment

Al-Hatamleh

Boer

et al. 2019

Cells

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Tumor necrosis factor receptor 2 (TNFR2) is expressed on some tumor cells, such as myeloma, Hodgkin lymphoma, colon cancer and ovarian cancer, as well as immunosuppressive cells. There is increasingly evidence that TNFR2 expression in cancer microenvironment has significant implications in cancer progression, metastasis and immune evasion. Although nanomedicine has been extensively studied as a carrier of cancer immunotherapeutic agents, no study to date has investigated TNFR2-targeting nanomedicine in cancer treatment. From an epigenetic perspective, previous studies indicate that DNA demethylation might be responsible for high expressions of TNFR2 in cancer models. This perspective review discusses a novel therapeutic strategy based on nanomedicine that has the capacity to target TNFR2 along with inhibition of DNA demethylation. This approach may maximize the anti-cancer potential of nanomedicine-based immunotherapy and, consequently, markedly improve the outcomes of the management of patients with malignancy.Cells 2020, 9, 33 2 of 16 and tumor cells [6][7][8]. In contrast, TNFR2 expression was only reported on tumor cells and suppressive immune cells, suggesting that TNFR2 directly promotes cancer development [9]. Furthermore, the latest preclinical and clinical studies confirmed the implication of TNF-TNFR2 signaling in cancer proliferation and the suppression of immune response [10,11]. Consequently, blockade of TNF-TNFR2 axis could be a promising option for cancer treatment (Figure 1).On the other hand, nanotechnology provided several platforms in the field of immunotherapy and made significant advances towards safe and efficient targeting systems with positive clinical outcomes and minimal side effects; this is the so-called field of nanomedicine [12]. Despite the emerging trends of using nanoparticles in immunotherapy, no studies have investigated any type of nanocarriers to target TNFR2 on cancer cells. However, based on some previous novel reports about the effects of nanoparticles on immune homeostasis [13], especially using nanoparticles to promote TNFR2 + Foxp3 + regulatory T cells (Tregs) in inflammatory models [14,15], we have suggested in our recent perspective review the possibility of blocking TNF-TNFR2 axis via nanoparticles [16].

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“…Masih banyak aspek teknologi nano yang perlu diteliti lebih lanjut, terutama profil keamanannya terkait tujuan penggunaan produk. 2,9,21…”

Section: Simpulanunclassified

Teknologi Nano Di Bidang Dermatologi Kosmetik

Angelia

Purwantyastuti

Rinaldi

et al. 2019

MDVI

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ABSTRAKNanosains merupakan salah satu cabang ilmu yang meneliti partikel -partikel kecil dalam skala atomik atau molekuler. Teknologi nano merupakan cabang baru bidang teknik yang melibatkan penggunaan partikel berskala nano (1-100 nm). Partikel nano dapat digunakan di berbagai bidang antara lain teknik, kimia, onkologi, dermatologi, dan lain-lain. Aplikasi dalam bidang dermatologi disebut sebagai nanodermatologi. Nanodermatologi merupakan bidang baru yang menarik minat banyak peneliti dan perusahaan farmasi. Teknologi nano telah menimbulkan revolusi dalam pengobatan beberapa penyakit kulit, terutama yang berkaitan dengan hantaran obat atau bahan kosmetik ke target kerja yang spesifik secara efektif. Potensi aplikasi teknologi nano di bidang dermatologi dan kosmetik, antara lain pada produk tabir surya, pelembab, formulasi anti penuaan, fototerapi, antiseptik, vaksin, obat kanker kulit, produk perawatan rambut, produk perawatan kuku, dan sebagainya. Dalam makalah ini akan dijelaskan mengenai teknologi nano, berbagai tipe partikel nano, aplikasi teknologi nano, dan pertimbangan keamanan partikel nano di bidang dermatologi dan kosmetik. Kata kunci: dermatologi; kosmetik; nanodermatologi; teknologi nano. NANOTECHNOLOGY IN COSMETIC DERMATOLOGY ABSTRACTNanoscience is the branch of science pertaining to the study of minute particles on an atomic or molecular scale, whose size is measured in nanometers, a scale where unique phenomena enable novel applications. Nanotechnology is an emerging branch of engineering that involves the use of particles on a nanoscale (1-100 nm). Nanoparticles can be used in various fields such as engineering, chemistry, oncology, dermatology, and others. The application of nanotechnology in the field of dermatology is nanodermatology. Nanotechnology has revolutionized the treatment of several skin diseases, since it increases the effectivity of targeted delivery of active medicaments and cosmetic ingredients. Nanotechnology in dermatology has opened a new era in the diagnosis and treatment of various skin disorders. Possible applications of nanotechnology in dermatology and cosmetics include products such as sunscreens, moisturizers, anti-aging formulations, phototherapy, antiseptic, vaccines, skin cancers medicaments, hair care, nail care, and others. This article covers an introduction of nanotechnology, various types of nanoparticles, various possible applications of nanotechnology, and safety of nanoparticles in dermatology and cosmetics.

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Nanomedicine and drug delivery: a mini review

Cited by 287 publications

References 77 publications

Imaging modification of colon carcinoma cells exposed to lipid based nanovectors for drug delivery: a scanning electron microscopy investigation

Imaging modification of colon carcinoma cells exposed to lipid based nanovectors for drug delivery: a scanning electron microscopy investigation

Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment

Teknologi Nano Di Bidang Dermatologi Kosmetik

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