Nanomedicines for the treatment of inflammatory bowel diseases

Ali, Hussain; Collnot, Eva-Maria; Windbergs, Maike; Lehr, Claus‐Michael

doi:10.1515/ejnm-2013-0004

Cited by 9 publications

(11 citation statements)

References 96 publications

(80 reference statements)

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“…The excessive density of amine groups present at the back-bone of deacetylated chitosan promotes strong electrostatic interactions with genes and proteins [61]. The cationic natural polymer for the past few years have being broadly investigated particularly as the main material in synthesizing carriers for therapeutic proteins and as non-viral gene carrying vectors [61][62][63]. Chitosan nanoparticles have an advantage of controlling the release of a drug thereby increasing drug stability and decreasing toxicity [58].…”

Section: (D) Chitosan Nanoparticlesmentioning

confidence: 99%

“…MOFs are organic-inorganic hybrid materials with three different dimensional structural topologies (1D, 2D and 3D) that consist of organic ligands and inorganic metal ions [72]. Their distinct features such as micro/mesoporosity with ultrahigh surface area and potential chemical functionalisation promoted their wide applications in the biomedical field [62][63][64]. MOF nanoparticles generally have high loading capacity and controlled release properties which makes them excellent candidates for drug delivery [73].…”

Section: (E) Carbon Nano Tubesmentioning

confidence: 99%

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Cockle Shell-Derived Calcium Carbonate (Aragonite) Nanoparticles: A Dynamite to Nanomedicine

et al. 2019

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Cockle shell is an external covering of small, salt water edible clams (Anadara granosa) that dwells in coastal area. This abundant biomaterial is hard, cheap and readily available with high content of calcium carbonate in aragonite polymorphic form. At present, cockle shell-derived calcium carbonate nanoparticles (CSCaCO3NPs) with dual applications has remarkably drawn significant attention of researchers in nanotechnology as a nanocarrier for delivery of different categories of drugs and as bone scaffold due to its beneficial potentials such as biocompatibility, osteoconductivity, pH sensitivity, slow biodegradation, hydrophilic nature and a wide safety margin. In addition, CSCaCO3NP possesses structural porosity, a large surface area and functional group endings for electrostatic ion bonds with high loading capacity. Thus, it maintains great potential in the drug delivery system and a large number of biomedical utilisations. The pioneering researchers adopted a non-hazardous top-down method for the synthesis of CSCaCO3NP with subsequent improvements that led to the better spherical diameter size obtained recently which is suitable for drug delivery. The method is therefore a simple, low cost and environmentally friendly, which involves little procedural steps without stringent temperature management and expensive hazardous chemicals or any carbonation methods. This paper presents a review on a few different types of nanoparticles with emphasis on the versatile most recent advancements and achievements on the synthesis and developments of CSCaCO3NP aragonite with its applications as a nanocarrier for drug delivery in nanomedicine.

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Section: (D) Chitosan Nanoparticlesmentioning

confidence: 99%

Section: (E) Carbon Nano Tubesmentioning

confidence: 99%

Cockle Shell-Derived Calcium Carbonate (Aragonite) Nanoparticles: A Dynamite to Nanomedicine

et al. 2019

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“…Whatever both are characterized by similar symptoms, for example, severe diarrhea, bodyweight loss, bloody stool and abdominal pain [23]. Pathological lesions and the position of the inflammation can distinguish between UC and CD to some extent [26]. In the case of UC, inflammation mainly affects the innermost mucosa and not involve the deeper tissues like serosa and muscularis.…”

Section: Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

“…The pathogenesis for IBD ( Figure 2) is to some level can be explained and understood, IBD is believed to occur due to dysregulation of the immune response to commensal microbiota in genetically susceptible individuals [26,31]. Much clinical evidence consider dysbiosis of the intestinal microbiome with developing of UC and CD [22,32].…”

Section: Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

“…Wide range of medicinal agents used for the treatment of IBD as 5-aminosalicylates, glucocorticoids, antibiotics, thiopurines, methotrexate, and biological treatment as TNF-α antibodies [23]. 5-aminosalicylates are the first line of the treatment for patients having mild to moderate UC and have a big role in induction and maintenance of remission periods at doses of 3000-4500 mg per day for sulfasalazine [26]. Aminosalicylates group include sulfasalazine [46], mesalazine [47], olsalazine [48,49], and balsalazide [50,51].…”

Section: Drug Molecules For Ibd Treatmentmentioning

confidence: 99%

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Colon Drug Delivery Systems for the Treatment of Inflammatory Bowel Disease.

Qelliny

Aly

Khaled

2019

Journal of advanced Biomedical and Pharmaceutical Sciences

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Inflammatory bowel disease (IBD) is one of the most common chronic diseases that affect the entire gastrointestinal tract (GIT) especially the colon. Its symptoms extend from mild diarrhea, abdominal pain, and bloody diarrhea to severe conditions which affect the quality of life. Many treatments have been developed to treat and cure IBD and to improve patient's quality of life. The big challenge faces the newly developed treatments is the site of action as the colon presents at the distal end of the GIT and have a complex biological environment. Many technologies have been investigated to target the colon, load higher amounts of active ingredients, and decrease unwanted side effects resulted from upper GIT absorption. This review briefly discusses the IBD, treatment lines, physiological considerations, and all methods of colon targeting technologies starting from the traditional methods which based on pH, time, and microbial content of the colon. Also, we discussed in detail all new techniques based on Micro and Nanotechnology which improve the effectiveness of used therapeutics.

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