A series of Bi-2223 ([Bi, Pb]:Sr:Ca:Cu:O = 2:2:2:3) tapes with 37 superconducting core filaments was investigated in an attempt to correlate critical current and alternating current (AC) losses with twist-pitch. The twist-pitch of these multi-filamentary tapes which were produced by the powder-in-(Ag)tube (PIT) method varies from 8, 10, 13, 30, 50, 70 mm to ∞ mm (non-twist). Critical current (I c) measurements which were conducted in zero field by a four-probe method under liquid-nitrogen temperature showed that I c is greater in the non-twist filament than that in twisted filaments. Among these tapes, three (twist-pitch of 10, 13, and 70 mm) were selected for AC loss experiments under a time-varying transport current. The results of AC loss measurements in general agree with that of the AC loss simulation using the ellipse model of the Norris equation. Simulation results show that the hysteretic AC loss is lowest in the non-twist tape and increases as the twist-pitch decreases. A much greater loss was found in tapes with small twist-pitch, i.e. 10 and 8 mm. Among different possible loss contributions to the total AC losses, the hysteretic loss was determined to be the main source. In addition, microstructural damage of tapes with small twist-pitch appears to contribute to the overall AC losses as well.