Nanomicellar-curcumin exerts its therapeutic effects via affecting angiogenesis, apoptosis, and T cells in a mouse model of melanoma lung metastasis

Mardani, Rajab; Hamblin, Michael R.; Taghizadeh, Mohsen; Banafshe, Hamid Reza; Nejati, Majid; Mokhtari, Mojgan; Borran, Sarina; Davoodvandi, Amirhossein; Khan, Haroon; Jaafari, Mahmoud Reza; Mirzaei, Hamed

doi:10.1016/j.prp.2020.153082

Cited by 48 publications

(20 citation statements)

References 25 publications

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“…Although in vivo studies suggested that the percentage of metastases in melanoma cancer patients is <0.1% of tumor cells, but a more significant number of cancerous cells are released in blood circulation in other types of cancer (Luzzi et al, 1998). To metastases progression, tumoral cells must move from their primary tumor site, disperse in blood circulation, tolerate blood vessels' pressure, conform to new cellular settings in a secondary tumor location, and avoid immunological responses (Maitra, 2019;Massagué and Obenauf, 2016). Hanahan and Weinberg (2011) have declared that "invasion and metastasis activation" are signs of tumors.…”

Section: Metastasismentioning

confidence: 99%

Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers

Davoodvandi

Farshadi²,

Zare

et al. 2021

Front. Pharmacol.

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Gastrointestinal (GI) cancers are known as frequently occurred solid malignant tumors that can cause the high rate mortality in the world. Metastasis is a significant destructive feature of tumoral cells, which directly correlates with decreased prognosis and survival. Curcumin, which is found in turmeric, has been identified as a potent therapeutic natural bioactive compound (Curcuma longa). It has been traditionally applied for centuries to treat different diseases, and it has shown efficacy for its anticancer properties. Numerous studies have revealed that curcumin inhibits migration and metastasis of GI cancer cells by modulating various genes and proteins, i.e., growth factors, inflammatory cytokines and their receptors, different types of enzymes, caspases, cell adhesion molecules, and cell cycle proteins. Herein, we summarized the antimetastatic effects of curcumin in GI cancers, including pancreatic cancer, gastric cancer, colorectal cancer, oral cancer, and esophageal cancer.

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Section: Metastasismentioning

confidence: 99%

Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers

Davoodvandi

Farshadi²,

Zare

et al. 2021

Front. Pharmacol.

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“…Notably, curcumin is suggested to affect various molecular signaling pathways and mechanisms (Ghasemi et al, 2019;Bagherian et al, 2020;Mardani et al, 2020;Salehi et al, 2020b). Until now, no naturally occurring compound has been investigated similar to curcumin.…”

Section: Curcumin and Molecular Pathways And Mechanismsmentioning

confidence: 99%

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

et al. 2020

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Immune response, proliferation, migration and angiogenesis are juts a few of cellular events that are regulated by transforming growth factor-β (TGF-β) in cells. A number of studies have documented that TGF-β undergoes abnormal expression in different diseases, e.g., diabetes, cancer, fibrosis, asthma, arthritis, among others. This has led to great fascination into this signaling pathway and developing agents with modulatory impact on TGF-β. Curcumin, a natural-based compound, is obtained from rhizome and roots of turmeric plant. It has a number of pharmacological activities including antioxidant, anti-inflammatory, anti-tumor, anti-diabetes and so on. Noteworthy, it has been demonstrated that curcumin affects different molecular signaling pathways such as Wnt/β-catenin, Nrf2, AMPK, mitogen-activated protein kinase and so on. In the present review, we evaluate the potential of curcumin in regulation of TGF-β signaling pathway to corelate it with therapeutic impacts of curcumin. By modulation of TGF-β (both upregulation and down-regulation), curcumin ameliorates fibrosis, neurological disorders, liver disease, diabetes and asthma. Besides, curcumin targets TGF-β signaling pathway which is capable of suppressing proliferation of tumor cells and invading cancer cells.

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“…The time and concentration of incubation are critical elements in imparting the potential activity of nanomicelle. Curcumin nanomicelles cause apoptosis even at low concentrations of 20 M. Curcumin also reduces angiogenesis and controls T Cell activation ( 232 ).…”

Section: Drug Delivery Systems Entrapping Natural Bioactive Compounds...mentioning

confidence: 99%

“…Co-encapsulation of BER was hypothesized to reduce the therapeutic dose of ETP, which would minimize its toxicity and overcome the problem of developing resistance and enhance its antitumor efficacy ( 275 ). When given in lung cancer-bearing mice, it leads to a decrease in vascular endothelial growth factor (VEGF) expression level, triggered caspase activation with tumor cell apoptosis, and enhanced antiangiogenic effect that might refer to synergistic topoisomerase II inhibition and reduction of multidrug resistance (MDR) effect in A549 cells ( 232 , 275 , 277 ). Thus, various plants possessing anticancer properties can be formulated with modifications to make them suitable for use as a theranostic leading to a substantial increase in the potency of anticancer drugs in the future.…”

Section: Future Prospectsmentioning

confidence: 99%

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

et al. 2022

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Cancer is a prominent cause of mortality globally, and it becomes fatal and incurable if it is delayed in diagnosis. Chemotherapy is a type of treatment that is used to eliminate, diminish, or restrict tumor progression. Chemotherapeutic medicines are available in various formulations. Some tumors require just one type of chemotherapy medication, while others may require a combination of surgery and/or radiotherapy. Treatments might last from a few minutes to many hours to several days. Each medication has potential adverse effects associated with it. Researchers have recently become interested in the use of natural bioactive compounds in anticancer therapy. Some phytochemicals have effects on cellular processes and signaling pathways with potential antitumor properties. Beneficial anticancer effects of phytochemicals were observed in both in vivo and in vitro investigations. Encapsulating natural bioactive compounds in different drug delivery methods may improve their anticancer efficacy. Greater in vivo stability and bioavailability, as well as a reduction in undesirable effects and an enhancement in target-specific activity, will increase the effectiveness of bioactive compounds. This review work focuses on a novel drug delivery system that entraps natural bioactive substances. It also provides an idea of the bioavailability of phytochemicals, challenges and limitations of standard cancer therapy. It also encompasses recent patents on nanoparticle formulations containing a natural anti-cancer molecule.

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Nanomicellar-curcumin exerts its therapeutic effects via affecting angiogenesis, apoptosis, and T cells in a mouse model of melanoma lung metastasis

Cited by 48 publications

References 25 publications

Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers

Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

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