Nanomolar cationic dendrimeric sulfadiazine as potential antitoxoplasmic agent

Prieto, María Jimena; Bacigalupe, D.; Pardini, Oscar Ricardo; Amalvy, Javier Ignacio; Venturini, Cecilia; Morilla, María José; Romero, Eder Lilia

doi:10.1016/j.ijpharm.2006.05.068

Cited by 55 publications

(30 citation statements)

References 35 publications

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“…We attribute the enhanced toxicity attenuation properties of the sialic acid containing polymers to the increased sialic acid valency in these materials. There are many examples of the role of valency in adhesion of ligands to multivalent materials [48][49][50][51][52][53]. More specific to Aβ, others have shown for biological membranes that Aβ binding affinity to sialic acid containing gangliosides increased in clustered or multivalent regions of the membrane compared to membrane regions where sialic acids or gangliosides were unclustered [25,30].…”

Section: Discussionmentioning

confidence: 99%

Development of photocrosslinked sialic acid containing polymers for use in Aβ toxicity attenuation

2008

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Abstractβ-Amyloid peptide (Aβ), the primary protein component in senile plaques associated with Alzheimer's disease (AD), has been implicated in neurotoxicity associated with AD. Previous studies have shown that the Aβ-neuronal membrane interaction plays a crucial role in Aβ toxicity. More specifically, it is thought that Aβ interacts with ganglioside rich and sialic acid rich regions of cell surfaces. In light of such evidence, we have hypothesized that the Aβ-membrane sialic acid interaction could be inhibited through use of a biomimic multivalent sialic acid compound that would compete with the cell surface for Aβ binding. To explore this hypothesis, we synthesized a series of photocrosslinked sialic acid containing oligosaccharides and tested their ability to bind Aβ and attenuate Aβ toxicity in cell culture assays. We show that a polymer prepared via the photocrosslinking of disialyllacto-N-tetraose (DSLNT) was able to attenuate Aβ toxicity at low micromolar concentrations without adversely affecting the cell viability. Polymers prepared from mono-sialyl-oligosaccharides were less effective at Aβ toxicity attenuation. These results demonstrate the feasibility of using photocrosslinked sialyl-oligosaccharides for prevention of Aβ toxicity in vitro and may provide insight into the design of new materials for use in attenuation of Aβ toxicity associated with AD.

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Section: Discussionmentioning

confidence: 99%

Development of photocrosslinked sialic acid containing polymers for use in Aβ toxicity attenuation

2008

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“…In the last years, strategies with chemical therapies, particularly the design of nano-structured drug carrier systems [6], have been proposed to overcome these issues regarding ASD treatment. However, these kinds of carriers (plain, ultradeformable, stealth, pH-sensitive liposomes, immunoliposomes, nanoparticles and dendrimers) must be carefully designed and/or chosen because their pharmacokinetics, biodistribution, and tissue selectivity depend exclusively on the nanocarrier structure [1], [7]–[9].…”

Section: Introductionmentioning

confidence: 99%

Optimization and In Vivo Toxicity Evaluation of G4.5 Pamam Dendrimer-Risperidone Complexes

et al. 2014

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Risperidone is an approved antipsychotic drug belonging to the chemical class of benzisoxazole. This drug has low solubility in aqueous medium and poor bioavailability due to extensive first-pass metabolism and high protein binding (>90%). Since new strategies to improve efficient treatments are needed, we studied the efficiency of anionic G4.5 PAMAM dendrimers as nanocarriers for this therapeutic drug. To this end, we explored dendrimer-risperidone complexation dependence on solvent concentration, pH and molar relationship. The best dendrimer-risperidone incorporation (46 risperidone molecules per dendrimer) was achieved with a mixture of chloroform:methanol 50∶50 v/v solution pH 3. In addition, to explore the possible effects of this complex, in vivo studies were carried out in the zebrafish model. Changes in the development of dopaminergic neurons and motoneurons were studied using tyrosine hydroxylase and calretinin, respectively. Physiological changes were studied through histological sections stained with hematoxylin-eosin to observe possible morphological brain changes. The most significant changes were observed when larvae were treated with free risperidone, and no changes were observed when larvae were treated with the complex.

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“…For a more efficient method of this drug delivery, Prieto et al assessed the possibility of using PAMAMs for its delivery [76]. They used commercially available G4 and G4.5 PAMAM dendrimers and loaded them with sulfadiazine.…”

Section: Dendrimers In Fighting Off the Parasitic/protozoa Infectionmentioning

confidence: 99%

Dendrimer Structure Diversity and Tailorability as a Way to Fight Infectious Diseases

Mlynarczyk¹,

Kocki²,

Gośliński³

2017

Nanostructured Materials - Fabrication to Applications

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Dendrimers represent a distinct class of polymers-highly branched and uniform, with a relatively small size when compared to their mass. They are composed of the core, from which branched polymeric dendrons diverge and they are end-capped with selected terminal groups. Recently, dendrimers have attracted considerable attention from medicinal chemists, mostly due to their well-defined and easy-to-modify structure. This chapter aims to compile dendrimer applications and activities especially for prevention and fighting off infections caused by bacteria and fungi, viruses, and parasites/protozoa. Our goal in this review is to discuss selected modifications of dendrimers of potential value for pharmaceutical chemistry.

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Nanomolar cationic dendrimeric sulfadiazine as potential antitoxoplasmic agent

Cited by 55 publications

References 35 publications

Development of photocrosslinked sialic acid containing polymers for use in Aβ toxicity attenuation

Development of photocrosslinked sialic acid containing polymers for use in Aβ toxicity attenuation

Optimization and In Vivo Toxicity Evaluation of G4.5 Pamam Dendrimer-Risperidone Complexes

Dendrimer Structure Diversity and Tailorability as a Way to Fight Infectious Diseases

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