Nanoparticle: a nightmare for the future

As the nano-world continues to evolve, nanotechnology offers tremendous potential in everyday goods and creating future, environmentally friendly technologies. The advantages of nanotechnology are being realized in various areas, including engineering, medicine, biology, the environment, and communication. However, nanomaterials production is expected to increase exponentially in the next few years, resulting in significant difficulties linked to their potentially harmful impacts on human health and the environment. Furthermore, the detrimental effect of the toxicity of nanomaterials on human health is one of the industry's most critical problems as it works to exhaust its supply of nano-products. The use of nanomaterials in biological applications is the scenario with the most significant risk. Therefore, the investigation of nanotoxicity and its interaction with biomolecules continues, as are many other projects. On the other hand, assessing and validating nanotoxicity in a biological system are complex tasks. This chapter aims to examine the difficulties associated with evaluating the toxicity of nanomaterials. The evaluation of toxicity and the problems encountered in assessing the effect on biological systems are historic. The findings of in-vitro, in-vivo, and in-silico investigations on the toxicity of engineered nanomaterials are described in this chapter. The various toxicity evaluation methods each have challenges that researchers must overcome when evaluating nanomaterials in powder form, solution-based approaches, and when interacting with biological systems. The evaluation tools and characterization methods are critical in overcoming the difficulties, while the cytotoxic tests consider nanoparticle form, morphology, and size.

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Investigation of In Vitro Antimicrobial and Cytotoxic Effects of Gold Nanoparticles Capped with Meropenem and Imipenem

Ciftci,

Sargin,

Arslan

et al. 2023

Nanomedicine (Lond.)

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Aim: This study aimed to investigate the in vitro antimicrobial effect of gold nanoparticles capped with meropenem and imipenem against various strains and to evaluate the cytotoxic effect of gold nanoparticles on healthy human colon epithelial cells. Materials & methods: Gold nanoparticles were synthesized via the Turkevich method and tested for antimicrobial effects using broth microdilution. Cell culture studies were performed using a cytotoxicity assay with alamarBlue™. Results & conclusion: Nanoparticles (10–20 nm) with antibiotic coating were more effective against Escherichia coli, Proteus spp. and Serratia marcescens than pure antibiotics. They had a cytotoxic effect on cells at high concentrations but were safe at low concentrations.

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Nanoparticle: a nightmare for the future

Abstract: ÖZET Nanopartikül: Geleceğin korkulu rüyasıNanoteknoloji 1-100 nanometre uzunluktaki partiküllerin kullanıldığı fizik, kimya, elektronik, enerji üretimi, biyoloji, tıp gibi

Cited by 5 publications

References 24 publications

An investigation into the architectural use of nanotechnology in the context of the titanium dioxide

An investigation into the architectural use of nanotechnology in the context of the titanium dioxide

Toxicology Related to Nanoparticles – Challenges and Future Prospects

Investigation of In Vitro Antimicrobial and Cytotoxic Effects of Gold Nanoparticles Capped with Meropenem and Imipenem

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