Nanoparticle-aggregated CuO nanoellipsoids for high-performance non-enzymatic glucose detection

Zhang, Xiaozhe; Sun, Shaodong; Lv, Jian; Tang, Linli; Kong, Chuncai; Song, Xiaoping; Yang, Zhimao

doi:10.1039/c4ta01005a

Cited by 83 publications

(42 citation statements)

References 46 publications

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“…As can be seen, the CuO electrode almost exhibits no catalytic activity toward electro-oxidation of glucose when the applied potential is below 0.1 V. The anodic current at the CuO electrode increases with the increase of the applied potential in the range of 0.20 .4 V, and decreases with further increase of the applied potential because that high potential could promote fast oxidation of glucose, which would lead to accumulation of intermediates and reaction products on the electrode surface and block of the catalytic active sites, and thus further oxidation of glucose being hindered [15]. This fact indicates the CuO electrode exhibits the highest electrocatalytic activity toward glucose oxidation at an applied potential of 0.4 V, which is lower than the detection potentials needed by most of other CuO-based enzymeless glucose sensors [22,24,28,29,33].…”

Section: Nonenzymatic Glucose Sensing Performancementioning

confidence: 89%

“…On the other hand, the introduced components in the CuO-based nanocomposites will inevitably cause production cost increasing. In addition, many micro-/ nanostructured CuO-based nonenzymatic sensors work only at a high applied potential (near to or higher than 0.6 V) [22,24,28,29], which can induce amperometric interference from the oxidation of many endogenous reducing substances such as AA, UA and dopamine (DA) in the biological fluids. Even so, the sensitivity for most of the current CuO-based enzymeless sensors is only of a magnitude of mA mM À1 cm…”

Section: à2mentioning

confidence: 99%

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Carnation‐like CuO Hierarchical Nanostructures Assembled by Porous Nanosheets for Nonenzymatic Glucose Sensing

Zhang

Xing

et al. 2016

Electroanalysis

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Carnation‐like CuO hierarchical nanostructures assembled by ultrathin porous nanosheets were successfully fabricated via a facile solvothermal route followed with heat treatment. As‐prepared CuO nanostructures exhibited excellent catalytic activity toward glucose oxidation in the absence of any enzymes. Under the optimized conditions, the CuO‐based enzymeless glucose sensor showed high sensitivity of 3.15 mA mM−1 cm−2, low limit of detection (98 nM, S/N=3), good reproducibility, excellent selectivity and long‐time stability. The superb nonenzymatic glucose sensing performance of the CuO hierarchical nanostructures was attributed to the highly catalytically active sites at the edges and basal planes of the CuO nanosheets, facile transportation of analytes through the abundant mesopores and macropores, robust and stable hierarchical structure. Moreover, the CuO‐based enzymeless glucose sensor showed high accuracy and reliability in comparison with clinical glucometer for quantitative determination of glucose in human blood serum samples.

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Section: Nonenzymatic Glucose Sensing Performancementioning

confidence: 89%

Section: à2mentioning

confidence: 99%

Carnation‐like CuO Hierarchical Nanostructures Assembled by Porous Nanosheets for Nonenzymatic Glucose Sensing

Zhang

Xing

et al. 2016

Electroanalysis

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“…[11][12][13] Nanostructured metal 4 oxides have been found to possess interesting nano-morphology, multiple oxidation states, and good biological compatibility. 6,14,15 These unique properties of nanosized metal oxides could alleviate the problems of expensive enzymatic glucose sensors.…”

Section: Introductionmentioning

confidence: 99%

“… 1,3,11,14,24,[35][37] Figure S8presents the current-time curve of the Cu foam-supported Cu 2 O electrode towards 10 nM glucose, displaying an obvious step-like increase of current due to the glucose addition.Figure 6e displays the typical amperometric detection of the Cu foam-supported Cu 2 O electrode at 0.55 V vs. Ag/AgCl owing to the stepwise addition of glucose from 0.1 µM to 1 mM.…”

mentioning

confidence: 98%

Three-Dimensional Cu Foam-Supported Single Crystalline Mesoporous Cu₂O Nanothorn Arrays for Ultra-Highly Sensitive and Efficient Nonenzymatic Detection of Glucose

Dong

Zhong

Kou

et al. 2015

ACS Appl. Mater. Interfaces

131

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Highly sensitive and efficient biosensors play a crucial role in clinical, environmental, industrial, and agricultural applications, and tremendous efforts have been dedicated to advanced electrode materials with superior electrochemical activities and low cost. Here, we report a three-dimensional binder-free Cu foam-supported Cu2O nanothorn array electrode developed via facile electrochemistry. The nanothorns growing in situ along the specific direction of <011> have single crystalline features and a mesoporous surface. When being used as a potential biosensor for nonenzyme glucose detection, the hybrid electrode exhibits multistage linear detection ranges with ultrahigh sensitivities (maximum of 97.9 mA mM(-1) cm(-2)) and an ultralow detection limit of 5 nM. Furthermore, the electrode presents outstanding selectivity and stability toward glucose detection. The distinguished performances endow this novel electrode with powerful reliability for analyzing human serum samples. These unprecedented sensing characteristics could be ascribed to the synergistic action of superior electrochemical catalytic activity of nanothorn arrays with dramatically enhanced surface area and intimate contact between the active material (Cu2O) and current collector (Cu foam), concurrently supplying good conductivity for electron/ion transport during glucose biosensing. Significantly, our findings could guide the fabrication of new metal oxide nanostructures with well-organized morphologies and unique properties as well as low materials cost.

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“…Accordingly, a number of metals, metal oxides, and metal alloys, such as Ni, CuO, Co 3 O 4 , PbO 2 , and Ir-Zn, for the fabrication of the non-enzymatic glucose sensors are reported [12][13][14][15]. CuO as a p-type semiconductor has been widely investigated for the non-enzymatic glucose sensing due to its good electrocatalytic activity [16,17].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of non-enzymatic glucose sensor based on bimetallic hollow Ag/Pt nanoparticles prepared by galvanic replacement reaction

Tang

Guo

et al. 2014

Ionics

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A non-enzymatic glucose sensor was successfully fabricated by immobilization of bimetallic hollow Ag/Pt nanoparticles (BH-Ag/Pt NPs) using the galvanic replacement reaction onto the surface of the pretreated pure Au electrode. The morphology and composition of the BH-Ag/Pt NPs were investigated by high-resolution transmission electron microscopy (HRTEM), scanning transmission electron microscopy (STEM), energy dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD), which proved the formation of bimetallic hollow Ag/Pt nanoparticles. The electroactive surface area and interface property of the Au electrode modified by BH-Ag/Pt NPs were measured by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The associated calculated values were 0.210 cm 2 and 11.30 Ω cm 2 , which were distinctly higher than those of the pure Au electrode. The electrocatalytic properties of the modified electrode toward glucose oxidation were evaluated by CV and differential pulse voltammetry (DPV). The results showed that the modified electrode had a high electrocatalytic activity toward glucose oxidation, a linear response to the glucose concentrations ranging from 1 to 12 mM covering the physiological level of 3-8 mM with a current sensitivity of 7 μA mM −1 and a low detection limit of 0.013 mM. Moreover, the modified electrode also showed ideal reproducibility, long-term stability, and high selectivity. It also showed good glucometer test values for real samples. Therefore, both of the facile preparation method and the excellent properties of the Au electrode modified by BH-Ag/Pt NPs could potentially be implemented to develop novel non-enzymatic glucose sensors.

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Nanoparticle-aggregated CuO nanoellipsoids for high-performance non-enzymatic glucose detection

Cited by 83 publications

References 46 publications

Carnation‐like CuO Hierarchical Nanostructures Assembled by Porous Nanosheets for Nonenzymatic Glucose Sensing

Carnation‐like CuO Hierarchical Nanostructures Assembled by Porous Nanosheets for Nonenzymatic Glucose Sensing

Three-Dimensional Cu Foam-Supported Single Crystalline Mesoporous Cu₂O Nanothorn Arrays for Ultra-Highly Sensitive and Efficient Nonenzymatic Detection of Glucose

Fabrication and characterization of non-enzymatic glucose sensor based on bimetallic hollow Ag/Pt nanoparticles prepared by galvanic replacement reaction

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Nanoparticle-aggregated CuO nanoellipsoids for high-performance non-enzymatic glucose detection

Cited by 83 publications

References 46 publications

Carnation‐like CuO Hierarchical Nanostructures Assembled by Porous Nanosheets for Nonenzymatic Glucose Sensing

Carnation‐like CuO Hierarchical Nanostructures Assembled by Porous Nanosheets for Nonenzymatic Glucose Sensing

Three-Dimensional Cu Foam-Supported Single Crystalline Mesoporous Cu2O Nanothorn Arrays for Ultra-Highly Sensitive and Efficient Nonenzymatic Detection of Glucose

Fabrication and characterization of non-enzymatic glucose sensor based on bimetallic hollow Ag/Pt nanoparticles prepared by galvanic replacement reaction

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Three-Dimensional Cu Foam-Supported Single Crystalline Mesoporous Cu₂O Nanothorn Arrays for Ultra-Highly Sensitive and Efficient Nonenzymatic Detection of Glucose