Nanoparticle based simple electrochemical biosensor platform for profiling of protein-nucleic acid interactions

Dai, Yifan; Chiu, Liang Yuan; Sui, Yongkun; Dai, Quanbin; Penumutchu, Srinivasa R.; Jain, Niyati; Dai, Liming; Zorman, Christian A.; Tolbert, Blanton S.; Sankaran, R. Mohan; Liu, Chung Chiun

doi:10.1016/j.talanta.2018.11.021

Cited by 19 publications

(19 citation statements)

References 34 publications

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“…The measured conductivities were between 10% and 50% that of their respective bulk metals, competitive with nanoparticle‐ and MOD‐based inks. The printed films were found to exhibit superior performance in chemical, [ 26 ] biological, [ 26,112 ] mechanical, [ 26 ] and environmental [ 113 ] sensor applications to those deposited using conventional sputtering methods.…”

Section: Schemesmentioning

confidence: 99%

Plasmas for additive manufacturing

Sui

Zorman

Sankaran

2020

Plasma Processes & Polymers

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Additive methods for manufacturing materials have recently emerged, particularly for the fabrication of three-dimensional architectures. Because of their long history in thin-film etching and deposition, plasmas offer unique advantages for many of the materials and surface processes associated with additive manufacturing. Here, we review recent efforts that have been primarily focused on the direct writing of patterned structures and the post-treatment of printed materials. Different configurations, materials, and applications are presented. Current challenges and a future outlook are also provided. 3D printing, additive manufacturing, microdischarges, nanotechnology, roll-to-roll

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Section: Schemesmentioning

confidence: 99%

Plasmas for additive manufacturing

Sui

Zorman

Sankaran

2020

Plasma Processes & Polymers

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“…Thef ormation of biomolecular layer is an essential step for the development of electrochemical biosensing. [45,55,57] Controlled and regulated formation of the biomolecule monolayer is critical and beneficial for electrochemistryguided electron transfer and understanding of surface biomolecular reaction, therefore leading to an enhanced, reproducible high-sensitivity performance for electrochemical biosensor.A ne lectrochemical approach for guided patterning DNAa rray on ag old-sensor surface was developed ( Figure 4A). [58] This controlled formation of the DNA monolayer bio-electrode was then further used to detect human methyltransferase, [59] an enzyme causing DNAm ethylation (further leading to cancer progression).…”

Section: Electrochemistry-directed Formation Of Biosurfaces For Contrmentioning

confidence: 99%

Recent Advances on Electrochemical Biosensing Strategies toward Universal Point‐of‐Care Systems

Dai

Liu

2019

Angewandte Chemie

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A number of very recently developed electrochemical biosensing strategies are promoting electrochemical biosensing systems into practical point‐of‐care applications. The focus of research endeavors has transferred from detection of a specific analyte to the development of general biosensing strategies that can be applied for a single category of analytes, such as nucleic acids, proteins, and cells. In this Minireview, recent cutting‐edge research on electrochemical biosensing strategies are described. These developments resolved critical challenges regarding the application of electrochemical biosensors to practical point‐of‐care systems, such as rapid readout, simple biosensor fabrication method, ultra‐high detection sensitivity, direct analysis in a complex biological matrix, and multiplexed target analysis. This Minireview provides general guidelines both for scientists in the biosensing research community and for the biosensor industry on development of point‐of‐care system, benefiting global healthcare.

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“…This OTFT platform was effective for antibody detection, and also for the quantification of bonding strength and charge discrimination capabilities. Comparing with electrochemical devices for quantification of biomolecular binding affinity [53], the direct transduction of binding affinity to electrical signal through OTFT demonstrated a potential universal platform for biophysical property analysis.…”

Section: Rapid Detection Strategymentioning

confidence: 99%

Recent Developments of Electrochemical and Optical Biosensors for Antibody Detection

Wang

et al. 2019

IJMS

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Detection of biomarkers has raised much interest recently due to the need for disease diagnosis and personalized medicine in future point-of-care systems. Among various biomarkers, antibodies are an important type of detection target due to their potential for indicating disease progression stage and the efficiency of therapeutic antibody drug treatment. In this review, electrochemical and optical detection of antibodies are discussed. Specifically, creating a non-label and reagent-free sensing platform and construction of an anti-fouling electrochemical surface for electrochemical detection are suggested. For optical transduction, a rapid and programmable platform for antibody detection using a DNA-based beacon is suggested as well as the use of bioluminescence resonance energy transfer (BRET) switch for low cost antibody detection. These sensing strategies have demonstrated their potential for resolving current challenges in antibody detection such as high selectivity, low operation cost, simple detection procedures, rapid detection, and low-fouling detection. This review provides a general update for recent developments in antibody detection strategies and potential solutions for future clinical point-of-care systems.

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Nanoparticle based simple electrochemical biosensor platform for profiling of protein-nucleic acid interactions

Cited by 19 publications

References 34 publications

Plasmas for additive manufacturing

Plasmas for additive manufacturing

Recent Advances on Electrochemical Biosensing Strategies toward Universal Point‐of‐Care Systems

Recent Developments of Electrochemical and Optical Biosensors for Antibody Detection

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