Nanoparticle-driven self-assembling injectable hydrogels provide a multi-factorial approach for chronic wound treatment

Advances in modified hyaluronic acid-based hydrogels for skin wound healing

“…167–171,251 Through careful selection of monomers and crosslinking agents, the hydrophilicity and porosity of the hydrogel was found to have an excellent effect in antibacterial applications. 172 HA-based hydrogels with antibacterial activity can be roughly divided into the following types according to the different antibacterial components: inorganic nanoparticles with antibacterial function (such as Ag nanoparticles, 173,174 ZnO 175 ), loading with antibiotic drugs, for example, antibiotic (gentamicin, 176 ampicillin 177 ), antimicrobial peptides(SWLSKTAKKLFKKIPKKIPKKRFPRPRPWPRPNMI-NH2, 178 KK(SLKL)3KK 179 ), antibacterial compounds (curcumin, 100 chlorhexidine diacetate, 153 polyarginine 180 ), materials capable of generating reactive oxygen species with bactericidal ability (Ag ions, 181 Zr-based porphyrinic metal−organic framework, 182 silver nanoparticles 183 ), and hydrogels that possess inherent antibacterial ability (bionic hydrogels obtained via dual-crosslinking between oxidized HA (HA-CHO) and dopa-grafted ε-polylysine, 184 a hydrogel with thiol derivatised HA and maleilated chitosan, 185 or a hydrogel made of HA, poly(vinylphosphonic acid), and chitosan 186 ).…”

Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

“…The highly selective character of antimicrobial agent-encapsulated cross-linked nanogels is beneficial for increasing the local concentration of the antimicrobial agent without damaging normal tissue. An important category is hybrid nanomaterials, and many of them have been applied for treatments of infectious disease [4,5,[37][38][39][40][41][42][43][44]. There are some examples of hybrid nanomaterials:…”

“…A hybrid hydrogel of organic collagen capped on an inorganic Ag NP and melatonin had been used to promote tissue regeneration of wounds with skin defects during multi-drug resistant bacterial infection [37]. Assemblies of organic thiolated hyaluronic acid with Ag NP hydrogels were effective against S. aureus infection in chronic wounds [38]. The hybrid NP with coating Ag on organic fluorhydroxyapatite had been shown to enhance its antimicrobial ability when applied in skeletal system implants [39].…”

“…Au NP combined with β-lactam antibiotic had been shown to be effective against MRSA infection [42]. (c) Theranostics hybrid nanomaterial: The hybrid of inorganic material (Mn3O4 NPs) with organic citrate (C-Mn3O4) and folic acid (FA-Mn3O4) ligands were bactericidal against An important category is hybrid nanomaterials, and many of them have been applied for treatments of infectious disease [4,5,[37][38][39][40][41][42][43][44]. There are some examples of hybrid nanomaterials:…”

Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration

“…In addition to damaging the local skin, diabetic foot ulcers can more than double the risk of mortality relative to that for patients without such ulcers . Owing to their impaired healing characteristics, diabetic wounds often necessitate long-term intensive care that can be extremely costly for affected patients, their families, and the healthcare system as a whole . Despite extensive research efforts aimed at improving wound healing outcomes, clinical management strategies for diabetic wounds remain suboptimal and expensive, underscoring the need for the development of new, more affordable approaches to patient care.…”