Nanoparticle Embedded Nanofiber Synthesis and Evaluation of Usability on Biomedical Applications

Abstract

When nanoparticles and nanofibers combined at the nanoscale, they could create new features in the material and therefore new areas of use. In this study, polyvinylpyrrolidone (PVP) nanofibers containing carbon nanoparticles produced by dense medium plasma technology have been fabricated via electrospinning technique for the first time, a new class of nanocomposite mat material has been prepared and evaluated for medical devices. A dense medium plasma technique is used for nanoparticles synthesis, which is novel, cost-efficient, and fast technology when is compared with other common nanoparticles synthesis techniques. Carbon based nanoparticles are synthesized from an arc sustained in benzene (purity, 99.5%) between iron electrodes by the lab-made dense medium plasma system. The study first mentions the production of nanoparticles by a pressure of 8 bar argon gas for glow discharge in a period of 9 seconds using a 0.5 cm electrode distance in a liquid environment (volume of benzene: 30 ml). Then, separated carbon nanoparticles are integrated with the PVP nanofibers produced by the electrospinning method. Processing parameters of PVP nanofibers containing carbon nanoparticle (nanocomposites) are optimized with various conditions such as polymer concentration: 7.8-8.0 %w/v, ratio of nanoparticle to polymer solution: 1-3.9 mg /ml, distance of electrode: 10-25 cm, processing time: 5-30 min. All samples are characterized by contact angle measurements, scanning electron microscopy and transmission electron microscopy. At the same time, electrical conductivity of nanocomposite mats are tested for foreseeing usage in biomedical application. Results showed that carbon nanoparticles have diameters in 25 ± 5.4 nm. New nanocomposite material production is proven by transmission electron microscopy. It is a super hydrophilic mat material (static contact angle is lower than 10°). According to the optimization of processing parameters, the diameters of nanocomposite fibers reach down to 150 ±75 nm., Nanocomposite mat resistance is found to be dramatically higher than that for the bare PVP nanofiber mat resistance. According to these results, usage in biomedical application of new material was discussed. It has a great potential to use as biocompatible, light, insulator new material.

Magnetic Response of Nano/Microparticles into Elastomeric Electrospun Fibers

“…Among different nanomaterials, magnetic nanoparticles (MNPs) have a variety of applications in various fields, including hyperthermia therapy [ 1 , 2 ], contrast agents in magnetic resonance imaging [ 3 , 4 ], and biosensing [ 5 , 6 ]. Recent studies demonstrated that electrospun fibers with embedded nanoparticles exhibit new functionalities at the nanoscale due to the optimization of process conditions [ 7 , 8 ], thus, showing improved performance and increased protection of nanoparticles from oxidation [ 9 ]. Similarly, magnetic nanoparticles embedded in nanofibers exhibit intriguing features [ 10 ] and offer magnetic-field-dependent mechanical properties [ 11 ].…”

“…Such magnetically responsive materials can be used as “smart” fibers in healthcare, such as bio-inspired membranes for wound healing [ 12 ], tissue engineering [ 13 ], sensors and actuators [ 14 , 15 ], magnetic hyperthermia in cancer treatment [ 16 ], and controlled drug release [ 17 ]. The physical properties of functionalized magnetic nanofibers (MNFs) can be tuned by incorporating different nanoparticles with specific magnetic properties and responses [ 7 ].…”

Effect of Pyrolysis Temperature on the Electrical Property and Photosensitivity of a PAN-PMMA Derived Carbon Fiber

“…Although there is considerable research regarding the electrical conductivity of carbon nanofibers, the effect of temperature has not been fully examined and studied. Similarly, the photosensitivity of carbon-based nanofibers has been studied for biomedical applications [21], but there has not been much attention regarding the photosensitivity of nanofibers for photoelectric energy converters and optoelectronic sensors.…”