Nanoparticle encapsulation and controlled release of a hydrophobic kinase inhibitor: Three stage mathematical modeling and parametric analysis

Lucero‐Acuña, Armando; Guzmán, Roberto

doi:10.1016/j.ijpharm.2015.07.049

Cited by 25 publications

(30 citation statements)

References 30 publications

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“…One of the most relevant mechanisms of release is initial burst, which is attributed to a process of interfacial diffusion between solid sphere surface and liquid media. By considering that initially all pVAX1-NH36 is incorporated in NPs, kinetics of initial burst follow an exponential relationship as reported in literature [53,54].…”

Section: Mathematical Analysis Of Pdna Releasementioning

confidence: 85%

“…Degradation of PLGA in aqueous solutions was carried out by hydrolysis, resulting in relaxation of NPs as evident in literature [56]. PLGA NPs degradation-relaxation effects have been explained by using the Prout-Tompkins equation [40,41,54,55]. This equation can also be used to describe pDNA release and could be rewritten in the following form:…”

Section: Mathematical Analysis Of Pdna Releasementioning

confidence: 99%

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Folate Functionalized PLGA Nanoparticles Loaded with Plasmid pVAX1-NH36: Mathematical Analysis of Release

et al. 2016

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Plasmid DNA (pVAX1-NH36) was encapsulated in nanoparticles of poly-dl-lactic-coglycolic (PLGA) functionalized with polyethylene glycol (PEG) and folic acid (PLGA-PEG-FA) without losing integrity. PLGA-PEG-FA nanoparticles loaded with pVAX1-NH36 (pDNA-NPs) were prepared by using a double emulsification-solvent evaporation technique. PLGA-PEG-FA synthesis was verified by FT-IR and spectrophotometry methods. pVAX1-NH36 was replicated in Escherichia coli (E. coli) cell cultures. Atomic force microscopy (AFM) analysis confirmed pDNA-NPs size with an average diameter of 177-229 nm, depending on pVAX1-NH36 loading and zeta potentials were below −24 mV for all preparations. In vitro release studies confirmed a multiphase release profile for the duration of more than 30-days. Plasmid release kinetics were analyzed with a release model that considered simultaneous contributions of initial burst and degradation-relaxation of nanoparticles. Fitting of release model against experimental data presented excellent correlation. This mathematical analysis presents a novel approach to describe and predict the release of plasmid DNA from biodegradable nanoparticles.

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Section: Mathematical Analysis Of Pdna Releasementioning

confidence: 85%

Section: Mathematical Analysis Of Pdna Releasementioning

confidence: 99%

Folate Functionalized PLGA Nanoparticles Loaded with Plasmid pVAX1-NH36: Mathematical Analysis of Release

et al. 2016

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“…Drug release from polymeric matrixes can be described by different mechanisms of release, depending on the properties of the drug, the matrix, the interactions between them, and the conditions of release, like temperature, pH, and others . One of the mechanisms that can be used to describe the release of drugs is Fickian diffusion.…”

Section: Resultsmentioning

confidence: 99%

“…One of the mechanisms that can be used to describe the release of drugs is Fickian diffusion. In this regard, we assumed a mass balance considering spherical coordinates, no chemical reaction of DOX, symmetry, sink conditions, the concentration of DOX, depending on the particle radius, constant effective diffusion coefficient, and transient conditions to obtain the following system of equations:

\frac{\partial C ((), r, t)}{\partial t} = D_{e} ((), \frac{\partial^{2} C ((), r, t)}{{\partial r}^{2}} + \frac{2}{r} \frac{\partial C ((), r, t)}{\partial r})

\frac{\partial C ((), 0, t)}{\partial r} = 0, t > 0

C ((),, r_{1}, t) = 0, t > 0

C ((), r, 0) = \frac{M_{i}}{v_{italicNP}}, 0 < r < r_{1}

…”

Section: Resultsmentioning

confidence: 99%

Temperature stimuli‐responsive nanoparticles from chitosan‐graft‐poly(N‐vinylcaprolactam) as a drug delivery system

Fernández‐Quiroz

Loya‐Duarte

Silva‐Campa

et al. 2019

J of Applied Polymer Sci

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This work describes the preparation of thermosensitive chitosan‐graft‐poly(N‐vinylcaprolactam) nanoparticles by ionic gelation and their potential use as a controlled drug delivery system, using doxorubicin as a model drug. A systematic study of the effect of the main processing parameters on both the size and thermoresponsive behavior of nanoparticles was investigated. The size of the particles is strongly dependent on the length of the poly(N‐vinylcaprolactam) grafted chains and the concentration of the copolymer and crosslinking agent solutions. The molecular structure of the copolymer plays an essential role in the phase transition temperature of the particles, which decreases with the length of PVCL grafted chain. The system displayed proper drug‐association parameters, and the drug‐loaded nanoparticles exhibited dose‐dependent cytotoxicity. A significant increase in the doxorubicin delivery rate was observed above the phase transition temperature (40 °C). These features indicate that these nanoparticles are suitable for the development of a new thermally controlled anti‐cancer drug delivery system. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47831.

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“…The ability to characterize and define nanoparticle interfaces in detail is highly relevant to understanding their function, as interfacial effects govern numerous important properties of nanoparticles such as hydration [14], encapsulation [15], and self-assembly behavior [16] to name but a few. Nevertheless, an accurate description of the nanoparticle interface is seldom incorporated into analysis.…”

Section: Introductionmentioning

confidence: 99%

A novel method for constructing continuous intrinsic surfaces of nanoparticles

Allen

Lorenz

2017

J Mol Model

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In recent years, the field of nanotechnology has become increasingly prevalent in the disciplines of science and engineering due to it’s abundance of application areas. Therefore, the ability to study and characterize these materials is more relevant than ever. Despite the wealth of simulation and modeling studies of nanoparticles reported in the literature, a rigorous description of the interface of such materials is rarely included in analyses which are pivotal to understanding interfacial behavior. We propose a novel method for constructing the continuous intrinsic surface of nanoparticles, which has been applied to a model system consisting of a sodium dodecyl sulfate micelle in the presence of testosterone propionate. We demonstrate the advantages of using our continuous intrinsic surface definition as a means to elucidate the true interfacial structure of the micelle, the interfacial properties of the hydrating water molecules, and the position of the drug (testosterone propionate) within the micelle. Additionally, we discuss the implications of this algorithm for future work in the simulation of nanoparticles. Graphical Abstractᅟ

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Nanoparticle encapsulation and controlled release of a hydrophobic kinase inhibitor: Three stage mathematical modeling and parametric analysis

Cited by 25 publications

References 30 publications

Folate Functionalized PLGA Nanoparticles Loaded with Plasmid pVAX1-NH36: Mathematical Analysis of Release

Folate Functionalized PLGA Nanoparticles Loaded with Plasmid pVAX1-NH36: Mathematical Analysis of Release

Temperature stimuli‐responsive nanoparticles from chitosan‐graft‐poly(N‐vinylcaprolactam) as a drug delivery system

A novel method for constructing continuous intrinsic surfaces of nanoparticles

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