Nanoparticle-Induced Permeability of Lipid Membranes

Pogodin, Sergey; Werner, Marco; Sommer, Jens‐Uwe; Baulin, Vladimir A.

doi:10.1021/nn3028858

Cited by 97 publications

(109 citation statements)

References 36 publications

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“…The prominent role of those functional groups, which render liposomes recognizable through hydrogen bonding, can be exploited to mimic analogous interactions occurring between cells. Morphological transition induced by molecular recognition is at the basis of intense investigations concerning protein-drug interactions and for understanding the mechanism behind versatile bioactivities of drugs [91,92,93,94]. …”

Section: Liposome-liposome Interaction and Molecular Recognition Pmentioning

confidence: 99%

Soft Interaction in Liposome Nanocarriers for Therapeutic Drug Delivery

et al. 2016

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The development of smart nanocarriers for the delivery of therapeutic drugs has experienced considerable expansion in recent decades, with the development of new medicines devoted to cancer treatment. In this respect a wide range of strategies can be developed by employing liposome nanocarriers with desired physico-chemical properties that, by exploiting a combination of a number of suitable soft interactions, can facilitate the transit through the biological barriers from the point of administration up to the site of drug action. As a result, the materials engineer has generated through the bottom up approach a variety of supramolecular nanocarriers for the encapsulation and controlled delivery of therapeutics which have revealed beneficial developments for stabilizing drug compounds, overcoming impediments to cellular and tissue uptake, and improving biodistribution of therapeutic compounds to target sites. Herein we present recent advances in liposome drug delivery by analyzing the main structural features of liposome nanocarriers which strongly influence their interaction in solution. More specifically, we will focus on the analysis of the relevant soft interactions involved in drug delivery processes which are responsible of main behaviour of soft nanocarriers in complex physiological fluids. Investigation of the interaction between liposomes at the molecular level can be considered an important platform for the modeling of the molecular recognition processes occurring between cells. Some relevant strategies to overcome the biological barriers during the drug delivery of the nanocarriers are presented which outline the main structure-properties relationships as well as their advantages (and drawbacks) in therapeutic and biomedical applications.

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Section: Liposome-liposome Interaction and Molecular Recognition Pmentioning

confidence: 99%

Soft Interaction in Liposome Nanocarriers for Therapeutic Drug Delivery

et al. 2016

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“…However, we did not consider the kinetics of embedding here, and as a result the full mechanism of penetration is still subject to additional study. The mechanism of penetration may involve a transient increase in membrane permeability, 43 lipid rearrangement similar to a vesicle fusion event, 44 or the existence of spontaneous membrane defects, which are prominent in biological membranes. 45,46 Translocation may also occur by a multiple state pathway similar to what is proposed for the insertion of membrane proteins or antimicrobial peptides, where particles first bind to the surface before inserting into the preferred transmembrane state.…”

mentioning

confidence: 99%

Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers

Lehn¹,

Atukorale²,

et al. 2013

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Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition.

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“…Such amphiphilicity has already been proven to be an important factor in determining the interactions between biological nanoobjects, such as cellpenetrating peptides, and either the cell membrane or a lipid bilayer [12][13][14] . Similar interactions between monolayer-protected AuNPs and lipid bilayers have been a subject of intense investigation by experimental and theoretical studies aimed at eliciting the role of surface charge, ligand composition and particle size among other tuning parameters on nano-bio interactions 6,[15][16][17][18][19][20][21][22][23] .…”

mentioning

confidence: 99%

Lipid tail protrusions mediate the insertion of nanoparticles into model cell membranes

et al. 2014

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Recent work has demonstrated that charged gold nanoparticles (AuNPs) protected by an amphiphilic organic monolayer can spontaneously insert into the core of lipid bilayers to minimize the exposure of hydrophobic surface area to water. However, the kinetic pathway to reach the thermodynamically stable transmembrane configuration is unknown. Here, we use unbiased atomistic simulations to show the pathway by which AuNPs spontaneously insert into bilayers and confirm the results experimentally on supported lipid bilayers. The critical step during this process is hydrophobic-hydrophobic contact between the core of the bilayer and the monolayer of the AuNP that requires the stochastic protrusion of an aliphatic lipid tail into solution. This last phenomenon is enhanced in the presence of high bilayer curvature and closely resembles the putative pre-stalk transition state for vesicle fusion. To the best of our knowledge, this work provides the first demonstration of vesicle fusion-like behaviour in an amphiphilic nanoparticle system.

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Nanoparticle-Induced Permeability of Lipid Membranes

Cited by 97 publications

References 36 publications

Soft Interaction in Liposome Nanocarriers for Therapeutic Drug Delivery

Soft Interaction in Liposome Nanocarriers for Therapeutic Drug Delivery

Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers

Lipid tail protrusions mediate the insertion of nanoparticles into model cell membranes

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