2018
DOI: 10.1021/acs.nanolett.8b02638
|View full text |Cite
|
Sign up to set email alerts
|

Nanoparticle Ligand Exchange and Its Effects at the Nanoparticle–Cell Membrane Interface

Abstract: The nanoparticle (nano)−cell membrane interface is one of the most important interactions determining the fate of nanoparticles (NPs), which can stimulate a series of biological events, allowing theranostic and other biomedical applications. So far, there remains a lack of knowledge about the mechanisms governing the nanoparticle−cell membrane interface, especially the impact of ligand exchange, in which molecules on the nanosurface become replaced with components of the cell membrane, resulting in unique inte… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

2
96
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 91 publications
(98 citation statements)
references
References 45 publications
2
96
0
Order By: Relevance
“…For instance, Wang et al found that the XPS characteristic peaks of citrate-AuNPs disappeared after interaction with POPC liposome solution, indicating a replacement of adsorbed citrates by POPC species. [185] Recently, high-resolution synchrotron radiation (SR) transmission, X-ray microscope (SR-TXM) has been developed as a novel tool to image NPs in a single cell with favorable sensitivity. Synchrotron radiation has more intense light sources, which significantly enhance the differentiation of metallic nanoparticle signals from cell background signals.…”
Section: X-ray Based Techniquesmentioning
confidence: 99%
“…For instance, Wang et al found that the XPS characteristic peaks of citrate-AuNPs disappeared after interaction with POPC liposome solution, indicating a replacement of adsorbed citrates by POPC species. [185] Recently, high-resolution synchrotron radiation (SR) transmission, X-ray microscope (SR-TXM) has been developed as a novel tool to image NPs in a single cell with favorable sensitivity. Synchrotron radiation has more intense light sources, which significantly enhance the differentiation of metallic nanoparticle signals from cell background signals.…”
Section: X-ray Based Techniquesmentioning
confidence: 99%
“…The properties of coating ligands on the surface of NPs are known to affect the integrity of the membranes, [ 60 ] which may regulate cell state, trigger inflammation, and causes cell death. [ 61 ] Thus, investigating the underlying mechanisms of the NP‐cell membrane interface is a key entry point for understanding nano‐safety issues. It is interesting that although through different mechanisms, the presence of the PC reduces the cytotoxicity of the NPs to a certain degree.…”
Section: Pc‐modulated Cytotoxicity Of Gnpsmentioning
confidence: 99%
“…It was reported recently that physisorbed ligands on the surface of NPs can be exchanged with lipid molecules as NPs cross the cell membrane, which would affect the structure of cell membrane. [ 61 ] Instead of other chemical ligands, bovine serum albumin (BSA)‐adsorbed GNPs (GNPs@BSA) would increase the thickness of ligand layer and prevent the ligand exchange process, and subsequently reduce membrane damage and cause lower cytotoxicity. A recent work has reported that GNRs protected by CTAB may rupture the cell membrane, causing cytotoxicity and inflammatory responses, due to the positive charge of CTAB.…”
Section: Pc‐modulated Cytotoxicity Of Gnpsmentioning
confidence: 99%
“…From a mechanistic point of view, experimental ESEM/TEM and theoretical CGMD approaches 3 have recently shown that the cellular uptake occurs through the ligand exchange at the nanoparticle/membrane interface. The physisorbed ligands on the nanoparticle surface have a larger ability to exchange with membrane lipidic molecules depending on their adsorption affinity and chain length.…”
mentioning
confidence: 99%
“…To discuss the internalization of the GNPs and the ligand exchange with the membrane, 3 we have elaborated DFT models of gold nanospheres, nanospikes (nanostars) and nanorod, 1 on the basis of a previous theoretical study investigating uncoated GNPs in the range 1-3.5 nm. 31 Due to the inherent limit of 3D models (5×5×5 nm 3 Before considering the monoshells of PEG ligands surrounding the Au nanoclusters, the most stable isolated adsorption forms have to be investigated for each shape and size. In Figure 1b and In the SI, all the optimized stable and metastable forms are presented with adsorption energies and key distances (see eq S2 of the SI and Figures S1-S5).…”
mentioning
confidence: 99%