Nanoparticle Properties Modulate Their Effect on the Human Blood Functions

Baravkar, Pravin Narayan; Sayyed, Anjum; Rahane, Chinmay Satish; Chate, Govind P.; Wavhale, Ravindra D.; Pratinidhi, Shilpa A.; Banerjee, Soumik

doi:10.1007/s12668-021-00874-x

Cited by 2 publications

(2 citation statements)

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“…The study found that positively charged GO nanoparticles were more hemolytic compared to negatively charged or Graphene Oxide Nanotoxicity: A Comprehensive Analysis DOI: http://dx.doi.org/10.5772/intechopen.114205 neutral GO nanoparticles. This observation suggested a greater electrostatic interaction between positively charged GO and negatively charged RBC membranes [63].…”

Section: Effect Of Surface Chemistry On Go Protein Interactionsmentioning

confidence: 89%

“…These interactions play a crucial role in influencing the overall toxicity of GO nanoparticles. A study by Zhang et al in 2018 investigated the effect of charge on GO's hemolytic activity using red blood cells (RBCs) [63]. The study found that positively charged GO nanoparticles were more hemolytic compared to negatively charged or Graphene Oxide Nanotoxicity: A Comprehensive Analysis DOI: http://dx.doi.org/10.5772/intechopen.114205 neutral GO nanoparticles.…”

Section: Effect Of Surface Chemistry On Go Protein Interactionsmentioning

confidence: 99%

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Graphene Oxide Nanotoxicity: A Comprehensive Analysis

Mahdi Sepahi,

Azizi

2024

Nanotechnology and Nanomaterials

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Graphene oxide (GO) has emerged as a promising nanomaterial with physicochemical properties that make it a candidate for a wide range of applications. However, the potential toxicity of GO is a significant threat that must be addressed before GO’s safe use in biomedical and environmental applications can fully be realized. Numerous studies have demonstrated that GO has the ability to induce oxidative stress, inflammation, genotoxicity, and cytotoxicity in cell types and animal models. Importantly, the toxicity of GO is influenced by its size, morphology, charge, and surface functional groups. The current review summarizes recent research findings on the toxicity of GO by focusing on its cellular uptake, biodistribution, and biological effects. It provides an overview of the current understanding of GO nanotoxicity and highlights the need for additional research to assess its safety in various applications. By addressing these concerns and developing appropriate safety measures, we can fully exploit the potential of GO while ensuring its safe utilization in biomedical and environmental settings. Thus, the comprehensive evaluation of GO’s potential risks is crucial for its full exploitation and utilization.

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Section: Effect Of Surface Chemistry On Go Protein Interactionsmentioning

confidence: 89%

Section: Effect Of Surface Chemistry On Go Protein Interactionsmentioning

confidence: 99%