Nanoparticles co-delivering pVSVMP and pIL12 for synergistic gene therapy of colon cancer

Xiao, Yuanyuan; Yang, Yuping; Wu, Yujiao; Wang, Chunmei; Cheng, Hao; Zhao, Wei; Yang, Li; Liu, Beibei; Gou, Maling; Guo, Wenhao; Gao, Guangping; Gou, Maling

doi:10.1039/c7ra03727a

Cited by 7 publications

(10 citation statements)

References 46 publications

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“…In another work, the Gou group developed heparin-polyethyleneimine (HPEI) nanoparticles to codeliver two plasmids encoding vesicular stomatitis virus matrix protein (VSVMP) and IL-12 (namely, HPEI/pIL12+pVSVMP), and confirmed that the nanoparticles could effectively deliver genes and enhance the effect of gene therapy (Figure 3A). 141 The obtained HPEI/pIL12+pVSVMP complexes not only promoted the apoptosis of C-26 cells in vitro but also significantly inhibited the proliferation of tumor cells as shown by K i67 staining results (Figure 3B and C). Moreover, the complexes resulted in T lymphocytes activation on a C-26 colon cancer model, thereby greatly reducing tumor metastasis nodules number and promoting anticancer immunity (Figure 3D).…”

Section: Delivery Of Immunomodulators With Nanomaterialsmentioning

confidence: 72%

“…Because of the strong protective effect of nanoparticles on plasmids, DTPA-modified PEI nanoparticles significantly increased IL-12 levels on the HepG2 cell line compared to unmodified PEI. In another work, the Gou group developed heparin-polyethyleneimine (HPEI) nanoparticles to codeliver two plasmids encoding vesicular stomatitis virus matrix protein (VSVMP) and IL-12 (namely, HPEI/pIL12+pVSVMP), and confirmed that the nanoparticles could effectively deliver genes and enhance the effect of gene therapy (Figure A) . The obtained HPEI/pIL12+pVSVMP complexes not only promoted the apoptosis of C-26 cells in vitro but also significantly inhibited the proliferation of tumor cells as shown by K i 67 staining results (Figure B and C).…”

Section: Delivery Of Immunomodulators With Nanomaterialsmentioning

confidence: 80%

Section: Delivery Of Immunomodulators With Nanomaterialsmentioning

confidence: 99%

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Nanomaterials as Smart Immunomodulator Delivery System for Enhanced Cancer Therapy

Yuan

Liu

Wang

et al. 2020

ACS Biomater. Sci. Eng.

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Immunomodulatory therapeutics, which is conducive to overcoming tumor tolerance and restoring normal immune responses, has been proposed as a promising approach for enhanced cancer therapy and clinical advancement. However, issues including cytokine syndrome, inefficient delivery, hepatic dysfunction, and severe adverse reactions remain to be resolved. It is particularly critical to develop delivery technologies to overcome these limitations and further improve antitumor efficacy. With the continuous development of materials science, biomaterials have been widely used in the field of cancer treatment and have also provided exciting solutions to overcome the bottleneck of immunomodulatory therapeutics. A range of biomaterials, especially nanomaterials, has been developed as a local immunomodulatory platform to enhance targeted delivery, maintain drug stability, and reduce toxicity and side effects. In addition to single immunomodulatory therapeutics, nanomaterials have been demonstrated to possess significant potential in immunomodulatory therapeutics-based synergistic therapies, especially in combination with phototherapy, radiotherapy, chemotherapy, and immune checkpoint blockade. In this review, as background to the discussion of immunomodulatory therapeutics, we first described the mechanisms of action of multiple immunomodulators and discussed their current targeting agents. On this basis, we highlighted the latest advances in the use of nanomaterials-assisted immunomodulatory therapeutics and combination therapy to enhance anticancer immunity. In addition, current challenges and further promises for immunomodulatory therapeutics were also presented.

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Section: Delivery Of Immunomodulators With Nanomaterialsmentioning

confidence: 72%

Section: Delivery Of Immunomodulators With Nanomaterialsmentioning

confidence: 80%

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Nanomaterials as Smart Immunomodulator Delivery System for Enhanced Cancer Therapy

Yuan

Liu

Wang

et al. 2020

ACS Biomater. Sci. Eng.

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“…IL-12 could activate both innate NK and CD8 + T cells for induction of tumor cell apoptosis, which together potentiated VSVMP-mediated anti-tumor effects and restrained the colonization of DTCs. 159 During the establishment of metastasis niches, DTCs actively recruit inflammatory cells (such as macrophages and monocytes), furthermore facilitating the extravasation of DTCs and the formation of immunosuppressive TME. Consequently, these immune cells are potential targets for tumor metastasis management.…”

Section: Tumor Immune Equilibrium: Nanoparticle-based Immunotherapy F...mentioning

confidence: 99%

Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment

et al. 2021

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Immunotherapy that harnesses the human immune system to fight cancer has received widespread attention and become a mainstream strategy for cancer treatment. Cancer immunotherapy not only eliminates primary tumors but also treats metastasis and recurrence, representing a major advantage over traditional cancer treatments. Recently with the development of nanotechnology, there exists much work applying nanomaterials to cancer immunotherapy on the basis of their excellent physiochemical properties, such as efficient tissue-specific delivery function, huge specific surface area, and controllable surface chemistry. Consequently, nanotechnology holds significant potential in improving the efficacy of cancer immunotherapy. Nanotechnology-based immunotherapy mainly manifests its inhibitory effect on tumors via two different approaches: one is to produce an effective anti-tumor immune response during tumorigenesis, and the other is to enhance tumor immune defense ability by modulating the immune suppression mechanism in the tumor microenvironment. With the success of tumor immunotherapy, understanding the interaction between the immune system and smart nanomedicine has provided vigorous vitality for the development of cancer treatment. This review highlights the application, progress, and prospect of nanomedicine in the process of tumor immunoediting and also discusses several engineering methods to improve the efficiency of tumor treatment.

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“…However, the treatment for soft tissue injury is still a big challenge in clinical practise as the curative effects of the above methods are not satisfactory [ 2 , 5 ]. Synergistic therapy is a widely explored method to improved curative effects for cancer therapy [ 6 , 7 ], which possesses improved curative effects compared with the cures using single drug or way. However, this method has been rarely explored in the treatment of injured soft tissues.…”

Section: Introductionmentioning

confidence: 99%

Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries

Zhang

Zuo

et al. 2019

Bioactive Materials

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Soft tissue injury is very common and associated with pain, tissue swelling and even malformation if not treated on time. Treating methods include cryotherapy, electrical therapy, ultrasound therapy and anti-inflammatory drug, but none of them is completely satisfying. In this work, for a better therapeutic effect, drug therapy and pulsed electromagnetic field (PEMF) therapy were combined. We constructed a drug delivery system using the tetra-PEG/agar hydrogel (PA). By incorporating Fe 3 O 4 NPs into the hydrogel network, a magnetism-responsive property was achieved in the system. The cytotoxicity and in vivo study showed a good biocompatibility of the PA/Fe 3 O 4 hydrogel. A magnetism-controlled release was attained by the incorporation of Fe 3 O 4 . Finally, in vivo study showed a better performance of the DS-loaded PA/Fe 3 O 4 compared with the commercially available DS ointment regarding the recovery of the injured soft tissue. Therefore, this magnetism-responsive hydrogel may represent a promising alternative to treat soft tissue injury.

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Nanoparticles co-delivering pVSVMP and pIL12 for synergistic gene therapy of colon cancer

Abstract: Nanoparticles delivering therapeutic genes have promising applications in cancer treatments.

Cited by 7 publications

References 46 publications

Nanomaterials as Smart Immunomodulator Delivery System for Enhanced Cancer Therapy

Nanomaterials as Smart Immunomodulator Delivery System for Enhanced Cancer Therapy

Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment

Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries

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