Nanoparticles for Bio-Medical Applications

Gisbert-Garzarán, Miguel; Vallet‐Regí, María

doi:10.3390/nano12071189

Cited by 10 publications

(2 citation statements)

References 16 publications

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“…Existe un interés creciente en el ámbito de la investigación biomédica por los materiales sílice mesoporosos nanoestructurados, campo en el que María Vallet-Regí et al han destacado de manera muy especial (48,(55)(56)(57)(58)(59). Estas biocerámicas bioactivas y biocompatibles permiten regenerar tejidos óseos y actúan también como sistemas de liberación controlada.…”

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Nanometrology and nanoanalytics: annotation in the bioanalytical and nano(biomedical)pharmaceutical context

Asuero

2022

an.ranf

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This annotation addresses the concepts of nanometrology and nanoanalytics, highlighting the importance of measurements and their metrological traceability at the nanoscale. The interdisciplinary nature of both analytical chemistry and nanotechnology is emphasized. This requires joining the efforts of different fields, e.g. chemistry, medicine, pharmacy, biology, materials science engineering, to face with guarantee the challenges that arise on different fronts. Some notes about nanomaterials and nanoparticles of interest in the bioanalytical and pharmaceutical context are commented. When it comes to therapeutic agents, nanomedicines help overcome the solubility, permeability, bioavailability, and toxicity limitations of conventional approaches, opening the door to precision therapies and personalized medicine. Being one of the objectives of analytical chemistry to carry out analysis at the nanometric scale, it also plays a role as an actor do your bit in the collective concert whose mission is to safeguard human health. Keywords: nanometrology; nanoanalytics; nanomedicine

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Nanometrology and nanoanalytics: annotation in the bioanalytical and nano(biomedical)pharmaceutical context

Asuero

2022

an.ranf

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“…In recent decades, the development of new nanomaterials for the treatment of bone defects and bone-related pathologies has experienced significant advances. Particularly, inorganic nanoparticles have shown great potential as nanosystems for diagnosis, drug delivery, magnetic hyperthermia, photothermal therapy, and gene transfection, and have provided new research expectations as well as new strategies for clinical practice [ 1 , 2 , 3 , 4 ]. In the field of bone defects and pathologies, bioactive mesoporous nanoparticles (MBNPs) have been an important advance in the last 15 years, contributing significantly to the improvement of implantable devices, such as coatings for endosseous prostheses, macroporous scaffolds, bone cements, etc.…”

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confidence: 99%

Mesoporous Bioactive Nanoparticles for Bone Tissue Applications

Arcos

Portolés

2023

IJMS

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Research in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures that stimulate bone tissue regeneration, since they have a composition similar to that of conventional sol–gel bioactive glasses and high specific surface area and porosity values. The rational design of mesoporosity and their ability to incorporate drugs make MBNPs an excellent tool for the treatment of bone defects, as well as the pathologies that cause them, such as osteoporosis, bone cancer, and infection, among others. Moreover, the small size of MBNPs allows them to penetrate inside the cells, provoking specific cellular responses that conventional bone grafts cannot perform. In this review, different aspects of MBNPs are comprehensively collected and discussed, including synthesis strategies, behavior as drug delivery systems, incorporation of therapeutic ions, formation of composites, specific cellular response and, finally, in vivo studies that have been performed to date.

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