Nanoparticles for bone tissue engineering

Vieira, Sílvia; Vial, Stéphanie; Reis, Rui L.; Oliveira, Joaquím M.

doi:10.1002/btpr.2469

Cited by 171 publications

(157 citation statements)

References 187 publications

(411 reference statements)

Supporting

Mentioning

149

Contrasting

Unclassified

Order By: Relevance

“…The first-generation quantum dots are semiconductors of crystalline structure [3]. In general, quantum dots have narrow emission spectra and broad absorption [3,27]. The most common ones are CdSe/ZnS, CdSeS/ZnS, and CdTe/ZnS, which were used in various biological applications due to their superiority over conventional fluorescent dyes, such as high photostability or excited state lifetime.…”

Section: Introductionmentioning

confidence: 99%

“…The most common ones are CdSe/ZnS, CdSeS/ZnS, and CdTe/ZnS, which were used in various biological applications due to their superiority over conventional fluorescent dyes, such as high photostability or excited state lifetime. Thanks to the aforementioned properties, QDs could be applied in long-term cell labelling and for dynamic biochemical process tracking [27]. Quantum dots were also successfully used in multicolor imaging due to their unique feature: an ability to be excited by one light source and detect different colors simultaneously [3].…”

Section: Introductionmentioning

confidence: 99%

“…Quantum dots were also successfully used in multicolor imaging due to their unique feature: an ability to be excited by one light source and detect different colors simultaneously [3]. However, these QDs were found to be toxic since they may generate reactive oxygen species (ROS) which are known to damage various proteins, lipids, and genetic material [27,28]. Moreover, Cd-based nanomaterials Molecules 2020, 25, 736 3 of 18 increased photostability and quantum yield [10,24,35].…”

Section: Introductionmentioning

confidence: 99%

“…The results showed that proposed strategy enables preparation of the superior nanomaterials with outstanding luminescence properties such as quantum yield up to 17% which can be successfully applied in cell labelling, bioimaging, and theranostics.Molecules 2020, 25, 736 2 of 18 can release cadmium ions leading to cell death. Importantly, it occurred that quantum dots may undergo certain modifications resulting in the change of their surface or chemical structure [27,28]. Finally, their preparation is expensive.…”

mentioning

confidence: 99%

“…Molecules 2020, 25, 736 2 of 18 can release cadmium ions leading to cell death. Importantly, it occurred that quantum dots may undergo certain modifications resulting in the change of their surface or chemical structure [27,28]. Finally, their preparation is expensive.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

et al. 2020

View full text Add to dashboard Cite

Carbon quantum dots (CQDs) are nanoobjects of a size below 10 nm. Due to their favorable features, such as tunable luminescence, unique optical properties, water solubility, and lack of cytotoxicity, they are willingly applied in biomedicine. They can be obtained via bottom-up and top-down methods. However, to increase their quantum yield they must undergo post-processing. The aim of the following research was to obtain a new type of CQDs modified with a rhodamine b derivative to enhance their fluorescence performance without biocompability deterioration. For their preparation glucose was used as a precursor and four different carbonizing agents which affected semi-and final products luminescence properties. The ready nanomaterials were investigated over their chemical structure by FTIR and NMR, whereas morphology was investigated by the TEM method. Their optical properties were determined by UV-VIS spectroscopy. Fluorescence behavior, photo-and pH-stability, as well as solvatochromism showed their applicability in various biomedical applications due to the controlled properties. The samples exhibited excellent antioxidant activity and lack of cytotoxicity on L929 mouse fibroblasts. The results showed that proposed strategy enables preparation of the superior nanomaterials with outstanding luminescence properties such as quantum yield up to 17% which can be successfully applied in cell labelling, bioimaging, and theranostics.Molecules 2020, 25, 736 2 of 18 can release cadmium ions leading to cell death. Importantly, it occurred that quantum dots may undergo certain modifications resulting in the change of their surface or chemical structure [27,28]. Finally, their preparation is expensive. Therefore, there was a need for a novel type of quantum dots which would be suitable for biomedical applications. In 2004, a new type of carbon-based materials was accidentally obtained during nanotube purification [29]. Until then, numerous types of carbon quantum dots (CQDs) have been obtained with various possible applications due to their very attractive properties, such as luminesce, good water solubility, high photostability, resistance to photobleaching or photoblinking, possibility, chemical inertness and, finally, lack of toxicity and biocompability [1][2][3]. Furthermore, CQDs' region of photoluminescence is very broad, starting in the ultraviolet and ending in the near-infrared. Although, until now, the luminescence behavior of carbon nanodots is still not fully clear, it is believed that crucial role plays two factors, namely, that the quantum size is below 10 nm and surface defects which may act as excitation energy traps. Interestingly, CQDs can successfully act as both electron donors and acceptors [2][3][4].CQDs can be prepared from various resources, such as peels (mango, orange, banana, pineapple, onion, seaweed etc.), meat, grains, nuts, or vegetable by-products, which makes them a low-cost material [30,31]. Currently, these nanomaterials are widely applied in drug delivery, gene delivery, biosensing, bioimag...

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%