Nanoparticles for Combined Cancer Imaging and Therapy

Bagalkot, Vaishali; Yu, Mi; Jon, Sangyong

doi:10.1002/9780470767047.ch23

Cited by 2 publications

(3 citation statements)

References 136 publications

(148 reference statements)

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“…A particle with more passes through the fenestrated tumor vasculature increases the overall probability of tumor uptake. 35,36 …”

Section: Resultsmentioning

confidence: 99%

“…A particle with more passes through the fenestrated tumor vasculature increases the overall probability of tumor uptake. 35,36 To reveal the spatial distribution of SWNTs accumulation, a tumor was collected and fixed for microtome slicing 100 h after SWNT injection. The tumor, with volume of ∼20 mm 3 , yielded 45 slices each with ∼40 μm thickness.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…These data support the assertion that a long circulation time is necessary for high tumor uptake of nanoparticles. A particle with more passes through the fenestrated tumor vasculature increases the overall probability of tumor uptake. , …”

Section: Resultsmentioning

confidence: 99%

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In Vivo Fluorescence Imaging in the Second Near-Infrared Window with Long Circulating Carbon Nanotubes Capable of Ultrahigh Tumor Uptake

et al. 2012

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Cancer imaging requires selective high accumulation of contrast agents in the tumor region and correspondingly low uptake in healthy tissues. Here, by making use of a novel synthetic polymer to solubilize single-walled carbon nanotubes (SWNTs), we prepared a well-functionalized SWNT formulation with long blood circulation (half life ~ 30 h) in vivo to achieve ultra-high accumulation of ~30% injected dose (ID)/gram in 4T1 murine breast tumors in Balb/c mice. Functionalization dependent blood circulation and tumor uptake was investigated through comparisons with phospholipid-PEG solubilized SWNTs. For the first time, we performed video-rate imaging of tumors based on the intrinsic fluorescence of SWNTs in the second near infrared (NIR-II, 1.1–1.4 µm) window. We carried out dynamic contrast imaging through principal component analysis (PCA) to immediately pinpoint the tumor within ~20 s post injection. Imaging over time revealed increasing tumor contrast up to 72 h post injection, allowing for its unambiguous identification. 3D reconstruction of the SWNTs distribution based on their stable photoluminescence inside the tumor revealed a high degree of colocalization of SWNTs and blood vessels, suggesting enhanced permeability and retention (EPR) effect as the main cause of high passive tumor uptake of the nanotubes.

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“…A particle with more passes through the fenestrated tumor vasculature increases the overall probability of tumor uptake. 35,36 …”

Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%