Nanoparticles for skin penetration enhancement – A comparison of a dendritic core-multishell-nanotransporter and solid lipid nanoparticles

Küchler, Sarah; Radowski, Michał R.; Blaschke, Tobias; Dathe, Margitta; Plendl, Johanna; Haag, Rainer; Schäfer‐Korting, Monika; Kramer, K.D.

doi:10.1016/j.ejpb.2008.08.019

Cited by 207 publications

(162 citation statements)

References 46 publications

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“…Amide-based CMS nanocarriers CMS-A18 were synthesized according to procedures published elsewhere [16].…”

Section: Synthesis Of the Cms Architecturesmentioning

confidence: 99%

“…While a unimolecular micelle consists of simple, usually hydrophilic polymeric chains anchored to a dendritic core [12], the CMS nanocarrier is a unimolecular structure that has a branched core-unit with amphiphilic polymeric chains attached to it, which at least consist of one hydrophilic and one hydrophobic block (see Figure 1). Frequently used core structures are the polyester Boltorn ® H40 [13,14], poly (ethyleneimine) (PEI) and the highly hydrophilic hyperbranched polyglycerolamine (hPG-NH2) [15,16]. Initially designed as a unimolecular liposome, the CMS nanotransporter has been reported by our group for the transport of both hydrophilic and lipophilic guest molecules [11,15].…”

Section: Introductionmentioning

confidence: 99%

“…Initially designed as a unimolecular liposome, the CMS nanotransporter has been reported by our group for the transport of both hydrophilic and lipophilic guest molecules [11,15]. The CMS nanocarrier can solubilize hydrophobic guest molecules in a hydrophilic environment and vice versa [16]. In contrast to other drug delivery systems (DDS), the mode of solubilization is physical entrapment upon which larger aggregates are formed.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast to other drug delivery systems (DDS), the mode of solubilization is physical entrapment upon which larger aggregates are formed. The CMS nanocarrier and its differently functionalized derivatives have been successfully used for the transport of the fluorescence dye ITCC in a tumor xenograft model as well as the penetration enhancement of the model drug Nile Red into skin [16,17]. Their aggregation phenomena and host-guest interactions have been studied both experimentally and theoretically [18,19].…”

Section: Introductionmentioning

confidence: 99%

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Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

et al. 2017

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Abstract:We here present the synthesis and characterization of a set of biodegradable core-multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12,15,18,19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ether (mPEG) outer shell that were conjugated by ester bonds only to reduce the toxicity of metabolites. The loading capacities (LC) of the drugs, dexamethasone and tacrolimus, and the aggregate formation, phase transitions, and degradation kinetics were determined. The intermediate inner shell length (C15) system had the best overall performance with good LCs for both drugs as well as a promising degradation and release kinetics, which are of interest for dermal delivery.

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“…Amide-based CMS nanocarriers CMS-A18 were synthesized according to procedures published elsewhere [16].…”

Section: Synthesis Of the Cms Architecturesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

et al. 2017

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“…The nanoparticles based on it have demonstrated significant ability to penetrate the skin through the follicular route (Küchler et al, 2009).…”

Section: Dendrimersmentioning

confidence: 99%

Biomaterials as novel penetration enhancers for transdermal and dermal drug delivery systems

2013

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The highly organized structure of the stratum corneum provides an effective barrier to the drug delivery into or across the skin. To overcome this barrier function, penetration enhancers are always used in the transdermal and dermal drug delivery systems. However, the conventional chemical enhancers are often limited by their inability to delivery large and hydrophilic molecules, and few to date have been routinely incorporated into the transdermal formulations due to their incompatibility and local irritation issues. Therefore, there has been a search for the compounds that exhibit broad enhancing activity for more drugs without producing much irritation. More recently, the use of biomaterials has emerged as a novel method to increase the skin permeability. In this paper, we present an overview of the investigations on the feasibility and application of biomaterials as penetration enhancers for transdermal or dermal drug delivery systems.

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Metal Nanoparticle Health Risk Assessment

et al. 2009

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Nanoparticles for skin penetration enhancement – A comparison of a dendritic core-multishell-nanotransporter and solid lipid nanoparticles

Cited by 207 publications

References 46 publications

Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

Biomaterials as novel penetration enhancers for transdermal and dermal drug delivery systems

Metal Nanoparticle Health Risk Assessment

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