Nanoparticles in wound healing from hope to promise from promise to routine

Abstract

Chronic non-healing wounds represent a growing problem due to their high morbidity and cost. Despite recent advances in wound healing, several systemic and local factors can disrupt the weighed physiologic healing process. This paper critically reviews and discusses the role of nanotechnology in promoting the wound healing process. Nanotechnology-based materials have physicochemical, optical and biological properties unique from their bulk equivalent. These nanoparticles can be incorporated into scaffolds to create nanocomposite smart materials, which promote wound healing through their antimicrobial, as well as selective anti- and pro-inflammatory, and pro-angiogenic properties. Owed to their high surface area, nanoparticles have also been used for drug delivery as well as gene delivery vectors. In addition, nanoparticles affect wound healing by influencing collagen deposition and realignment and provide approaches for skin regeneration and wound healing.

Recent Advances in Nanomaterial-Based Wound-Healing Therapeutics

“…The use of nanomaterials in wound healing is expanding rapidly; furthermore, nanotherapy-based wound-healing treatments are under clinical investigation [6,38,39]. The basic reason underlying the increased use of nanomaterials can be attributed to their physiochemical properties including nano size, large surface area, and high surface area-to-volume ratios.…”

The Use of Metallic Nanoparticles in Wound Healing: New Perspectives

“…These wound healing nanoscale delivery systems have better delivery of poorly water-soluble drugs, protect the therapeutic against temperature, light, pH, or enzyme degradation at the site of administration, and further stimulate fibroblast proliferation, reduce inflammation and reduce cytotoxicity of certain drugs [ 140 ]. Therefore, the involvement of nanotechnology through the therapeutically active dressing in the delivery of growth factors and pro-angiogenesis compounds along with other therapeutic agents (e.g., antimicrobials) serves as a potential revolution in wound care [ 141 ].…”

Hypericum genus cosmeceutical application – A decade comprehensive review on its multifunctional biological properties

“…Nanotechnology has played a role in promoting the wound healing process. The encapsulated bioactive ingredients and some of the polymeric materials exhibit potent antimicrobial, anti-inflammatory, and pro-angiogenic properties (Naderi et al, 2018). Hypericin is a potent photosensitiser identified in most Hypericum species.…”