Nanoparticles' interactions with vasculature in diseases

Tee, Jie Kai; Yip, Li Xian; Tan, Eveline Sheau; Santitewagun, Supawan; Prasath, Arun; Ke, Pu Chun; Ho, Han Kiat; Leong, David Tai

doi:10.1039/c9cs00309f

Cited by 263 publications

(205 citation statements)

References 217 publications

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“…It is likely that these particles would remain in the fetus after birth. Endothelial cell exposure to engineered nanomaterials enhances endothelial barrier permeability [35,36,37], which offers accessibility to the interstitial space between cells within systemic tissues. Reports pertaining to the development and function of the blood brain barrier in a fetus are inconclusive [38,39].…”

Section: Discussionmentioning

confidence: 99%

Nanopolystyrene Translocation and Fetal Deposition After Acute Lung Exposure During Late-Stage Pregnancy

Fournier

D’Errico

Adler

et al. 2020

Preprint

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Abstract Background: Plastic is everywhere. It is used in food packaging, storage containers, electronics, furniture, clothing, and common single-use disposable items. Microplastic and nanoplastic particulates are formed from bulk fragmentation and disintegration of plastic pollution. Plastic particulates have recently been detected in indoor air and remote atmospheric fallout. Due to their small size, microplastic and nanoplastic particulate in the atmosphere can be inhaled and may pose a risk for human health, specifically in susceptible populations. When inhaled, nanosized particles have been shown to translocate across pulmonary cell barriers to secondary organs, including the placenta. However, the potential for maternal-to-fetal translocation of nanosized-plastic particles and the impact of nanoplastic deposition and accumulation on fetal health remain unknown. In this study we investigated whether nanopolystyrene particles can cross the placental barrier and deposit in fetal tissues after maternal pulmonary exposure.Results: Pregnant Sprague Dawley rats were exposed to 20 nm rhodamine-labeled nanopolystyrene beads (2.64 x 1014 particles) via intratracheal instillation on gestational day (GD) 19. Twenty-four hours later on GD 20, maternal and fetal tissues were evaluated using fluorescent optical imaging. Fetal tissues were fixed for particle visualization with hyperspectral microscopy. Using isolated placental perfusion, a known concentration of nanopolystyrene was injected into the uterine artery. Maternal and fetal effluents were collected for 180 minutes and assessed for polystyrene particle concentration. Twenty-four hours after maternal exposure, fetal and placental weights were significantly lower (7% and 8%, respectively) compared with controls. Nanopolystyrene particles were detected in the maternal lung, heart, and spleen. Polystyrene nanoparticles were also observed in the placenta, fetal liver, lungs, heart, kidney, and brain suggesting maternal lung-to-fetal tissue nanoparticle translocation in late stage pregnancy.Conclusion: These studies confirm that maternal pulmonary exposure to nanopolystyrene results in the translocation of plastic particles to placental and fetal tissues and renders the fetoplacental unit vulnerable to adverse effects. These data are vital to the understanding of plastic particulate toxicology and the developmental origins of health and disease.

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Section: Discussionmentioning

confidence: 99%

Nanopolystyrene Translocation and Fetal Deposition After Acute Lung Exposure During Late-Stage Pregnancy

Fournier

D’Errico

Adler

et al. 2020

Preprint

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“…[ 19 ] Moreover, the interaction of inorganic nanoparticles with the endothelial cells lining tumor blood vessels induces vascular leakiness, a phenomenon recently dubbed the nanomaterial‐induced endothelial leakiness (NanoEL) effect. [ 20 ] It is important to note that the NanoEL and EPR effects may be similar in the context of endothelial leakiness, but are quite different when it comes to their specific nature and applicability.…”

Section: Understanding the Nano–tme Interfacementioning

confidence: 99%

Designing Stimuli‐Responsive Upconversion Nanoparticles that Exploit the Tumor Microenvironment

et al. 2020

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Tailoring personalized cancer nanomedicines demands detailed understanding of the tumor microenvironment. In recent years, smart upconversion nanoparticles with the ability to exploit the unique characteristics of the tumor microenvironment for precise targeting have been designed. To activate upconversion nanoparticles, various bio‐physicochemical characteristics of the tumor microenvironment, namely, acidic pH, redox reactants, and hypoxia, are exploited. Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn2+ in tumors. An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided. Detailed understanding of the tumor microenvironment and the personalized design of upconversion nanoparticles will result in more effective clinical translation.

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“…A host of diseases rely on improper vascular integrity, and the NanoEL effect might lead to the development of vascular diseases. [36] In addition, iron oxide NPs (spherical: 10 nm) were directly able to induce endothelial-to-mesenchymal transitions (EndMT) in cultured human umbilical vein endothelial cells (HUVECs), [37] which is a process implicated in diseases such as fibrosis, cancer, vascular disorders and inflammatory states. [38] This involves a phenotypic change that can also perturb endothelial barrier integrity.…”

Section: Metallic Nps Can Cause Vascular Disturbances Through Disruptmentioning

confidence: 99%

All Roads Lead to the Liver: Metal Nanoparticles and Their Implications for Liver Health

Boey

2020

Small

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Metal nanoparticles (NPs) are frequently encountered in daily life, and concerns have been raised about their toxicity and safety. Among which, they naturally accumulate in the liver after introduction into the body, independent of the route of administration. Some NPs exhibit intrinsic pharmaceutical effects that are related to their physical parameters, and their inadvertent accumulation in the liver can exert strong effects on liver function and structure. Even as such physiological consequences are often categorically dismissed as toxic and deleterious, there are cell type‐specific and NP‐specific biological responses that elicit distinctive pharmacological consequences that can be harnessed for good. By limiting the scope of discussion to metallic NPs, this work attempts to provide a balanced perspective on their safety in the liver, and discusses both possible therapeutic benefits and potential accidental liver damage arising from their interaction with specific parenchymal and nonparenchymal cell types in the liver.

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Nanoparticles' interactions with vasculature in diseases

Abstract: The ever-growing use of inorganic nanoparticles (NPs) in biomedicine provides an exciting approach to develop novel imaging and drug delivery systems, owing to the ease with which these NPs can be functionalized to cater to the various applications.

Cited by 263 publications

References 217 publications

Nanopolystyrene Translocation and Fetal Deposition After Acute Lung Exposure During Late-Stage Pregnancy

Nanopolystyrene Translocation and Fetal Deposition After Acute Lung Exposure During Late-Stage Pregnancy

Designing Stimuli‐Responsive Upconversion Nanoparticles that Exploit the Tumor Microenvironment

All Roads Lead to the Liver: Metal Nanoparticles and Their Implications for Liver Health

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