Nanoparticles, nanotechnology and pulmonary nanotoxicology

Ferreira, António Jorge; Cemlyn-Jones, Jessica; Cordeiro, Carlos Robalo

doi:10.1016/j.rppnen.2013.01.004

Cited by 19 publications

(10 citation statements)

References 57 publications

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“…Human exposure to NPs may alter heart rate and blood pressure (16,47). NPs toxicity has also been reported in the digestive system, nervous system, kidney, liver, reproductive system, and skin and has been reported to alter body immune responses in exposed subjects (11).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles: An Experimental Study of Zinc Nanoparticles Toxicity on Marine Crustaceans. General Overview on the Health Implications in Humans

Vimercati

Cavone

Caputi

et al. 2020

Front. Public Health

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The presence of products containing nanoparticles or nanofibers is rapidly growing. Nanotechnology involves a wide spectrum of industrial fields. There is a lack of information regarding the toxicity of these nanoparticles in aqueous media. The potential acute toxicity of ZnO NPs using two marine crustacean species: the copepod Tigriopus fulvus and the amphypod Corophium insidiosum was evaluated. Acute tests were conducted on adults of T. Fulvus nauplii and C. insidiosum. Both test species were exposed for 96 h to 5 increasing concentrations of ZnO NPs and ZnSO 4 H 2 O, and the endpoint was mortality. Statistical analysis revealed that the mean LC50 values of both ZnO NPs and ZnSO 4 H 2 O (ZnO NPs: F = 59.42; P < 0.0015; ZnSO 4 H 2 O: F = 25.57; P < 0.0015) were significantly lower for Tigriopus fulvus than for Corophium insidiosum. This result confirms that the toxic effect could be mainly attributed to the Zn ions, confirming that the dissolution processes play a crucial role in the toxicity of the ZnO NPs.

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Section: Introductionmentioning

confidence: 99%

Nanoparticles: An Experimental Study of Zinc Nanoparticles Toxicity on Marine Crustaceans. General Overview on the Health Implications in Humans

Vimercati

Cavone

Caputi

et al. 2020

Front. Public Health

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“…[3][4][5][6][7][8][9][10] Unfortunately, the extensive use of nanostructures without considering their implications has posed a significant risk to environment, which directly has influenced plants, animals, and human. [11][12][13][14][15] Therefore, the investigation of nanostructures toxicity seems critical to not only understand their functional mechanisms but also decrease their harmful and negative impacts on human health. [16][17][18] It is obvious that nanostructures can penetrate human cells through inhalation, ingestion, dermal contact and injection.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo study of hazardous effects of Ag nanoparticles and Arginine‐treated multi walled carbon nanotubes on blood cells: Application in hemodialysis membranes

Zare‐Zardini

Amiri

Shanbedi

et al. 2015

J Biomedical Materials Res

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One of the novel applications of the nanostructures is the modification and development of membranes for hemocompatibility of hemodialysis. The toxicity and hemocompatibility of Ag nanoparticles and arginine-treated multiwalled carbon nanotubes (MWNT-Arg) and possibility of their application in membrane technology are investigated here. MWNT-Arg is prepared by amidation reactions, followed by characterization by FTIR spectroscopy, Raman spectroscopy, and thermogravimetric analysis. The results showed a good hemocompatibility and the hemolytic rates in the presence of both MWNT-Arg and Ag nanoparticles. The hemolytic rate of Ag nanoparticles was lower than that of MWNT-Arg. In vivo study revealed that Ag nanoparticle and MWNT-Arg decreased Hematocrit and mean number of red blood cells (RBC) statistically at concentration of 100 µg mL(-1) . The mean decrease of RBC and Hematocrit for Ag nanoparticles (18% for Hematocrit and 5.8 × 1,000,000/µL) was more than MWNT-Arg (20% for Hematocrit and 6 × 1000000/µL). In addition, MWNT-Arg and Ag nanoparticles had a direct influence on the White Blood Cell (WBC) drop. Regarding both nanostructures, although the number of WBC increased in initial concentration, it decreased significantly at the concentration of 100 µg mL(-1) . It is worth mentioning that the toxicity of Ag nanoparticle on WBC was higher than that of MWNT-Arg. Because of potent antimicrobial activity and relative hemocompatibility, MWNT-Arg could be considered as a new candidate for biomedical applications in the future especially for hemodialysis membranes.

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“…Combined effects of UFP high surface area and potentially toxic composition may promote physical and chemical reactions inside the organisms that can further result in adverse health outcomes (Kumar et al., ; Stone et al., ). Studies have shown that exposures to UFP are associated with impaired lung function and pulmonary defense mechanisms, inflammatory responses, asthma, worsening of respiratory diseases and allergic conditions, cardiovascular problems, and even with carcinogenic and genotoxic consequences (Ferreira et al., ; Stanek et al., ; Terzano et al., ).…”

Section: Introductionmentioning

confidence: 99%

Assessment of ultrafine particles in Portuguese preschools: levels and exposure doses

et al. 2014

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The aim of this work was to assess ultrafine particles (UFP) number concentrations in different microenvironments of Portuguese preschools and to estimate the respective exposure doses of UFP for 3-5-year-old children (in comparison with adults). UFP were sampled both indoors and outdoors in two urban (US1, US2) and one rural (RS1) preschool located in north of Portugal for 31 days. Total levels of indoor UFP were significantly higher at the urban preschools (mean of 1.82 9 10 4 and 1.32 9 10 4 particles/cm 3 at US1 an US2, respectively) than at the rural one (1.15 9 10 4 particles/cm 3 ). Canteens were the indoor microenvironment with the highest UFP (mean of 5.17 9 10 4 , 3.28 9 10 4 , and 4.09 9 10 4 particles/cm 3 at US1, US2, and RS1), whereas the lowest concentrations were observed in classrooms (9.31 9 10 3 , 11.3 9 10 3 , and 7.14 9 10 3 particles/cm 3 at US1, US2, and RS1). Mean indoor/outdoor ratios (I/O) of UFP at three preschools were lower than 1 (0.54-0.93), indicating that outdoor emissions significantly contributed to UFP indoors. Significant correlations were obtained between temperature, wind speed, relative humidity, solar radiation, and ambient UFP number concentrations. The estimated exposure doses were higher in children attending urban preschools; 3-5-yearold children were exposed to 4-6 times higher UFP doses than adults with similar daily schedules.

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Nanoparticles, nanotechnology and pulmonary nanotoxicology

Cited by 19 publications

References 57 publications

Nanoparticles: An Experimental Study of Zinc Nanoparticles Toxicity on Marine Crustaceans. General Overview on the Health Implications in Humans

Nanoparticles: An Experimental Study of Zinc Nanoparticles Toxicity on Marine Crustaceans. General Overview on the Health Implications in Humans

In vitro and in vivo study of hazardous effects of Ag nanoparticles and Arginine‐treated multi walled carbon nanotubes on blood cells: Application in hemodialysis membranes

Assessment of ultrafine particles in Portuguese preschools: levels and exposure doses

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