Nanoparticles of Hybrid Liposomes for the Inhibition of Breast Tumor Growth along with Apoptosis

Shimoda, Shinya; Ichihara, Hideaki; Matsumoto, Yōko; Ueoka, Ryuichi

doi:10.1246/cl.2009.134

Chemistry Letters

2008

DOI: 10.1246/cl.2009.134

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Nanoparticles of Hybrid Liposomes for the Inhibition of Breast Tumor Growth along with Apoptosis

Shinya Shimoda

Hideaki Ichihara

Yōko Matsumoto

et al.

Abstract: Hybrid liposomes (HLs) composed of l-α-dimyristoylphosphatidylcholine and polyoxyethylene (25) dodecyl ether having 80 nm in diameter were produced. It is noteworthy that the therapeutic effects of HLs along with apoptosis without side effect were obtained using xenograft mice models of human breast cancer in vivo for the first time.

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Cited by 3 publications

References 11 publications

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Clustering of Lipid Rafts in Plasma Membranes by Hybrid Liposomes for Leukemia Cells along with Apoptosis

Komizu¹,

Nakata²,

Goto³

et al. 2010

Chemistry Letters

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Clustering of lipid rafts in plasma membranes by hybrid liposomes (HL-23) composed of l-α-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene(23) dodecyl ether (C12(EO)23) for human leukemia HL-60 cells was observed for the first time. It was suggested that the induction of apoptosis by HL-23 could be related to an increase of membrane fluidity and the formation of lipid rafts in the plasma membranes of HL-60 cells.

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Clustering of Lipid Rafts in Plasma Membranes by Hybrid Liposomes for Leukemia Cells along with Apoptosis

Komizu¹,

Nakata²,

Goto³

et al. 2010

Chemistry Letters

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Inhibitory Effects of Hybrid Liposomes Composed of Phosphatidylcholine and Docosahexaenoic Acid on the Growth of Colon Cancer Cells along with Apoptosis and Differentiation

Goto¹,

Zako²,

Komizu³

et al. 2010

Chemistry Letters

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Chemotherapy with Hybrid Liposomes for Tumor in Relation to Fluctuation of Membranes

Matsumoto¹,

Ichihara²,

Ueoka³

2011

MEMBRANE

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"Molecular science of fluctuations toward biological functions" should be important for understanding the origin of life. Membrane-fluctuations of tumor cells are very different from those of normal cells. In general, the membranes of tumor cells are more fluid as compared with normal cells. We have produced hybrid liposomes (HL) which can be prepared by sonication of vesicular and micellar molecules in a buffer solution. The physical properties of HL such as size, shape, membrane fluidity, and the temperature of phase separation can be controlled by changing the constituents and compositional ratio. The uniform and stable structure of HL-n composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylenedodecyl ether (C 12 (EO) n : n = 21~25) with a diameter of 80 nm was revealed.The remarkable inhibitory effects of HL on the growth of various tumor cells were attained in vitro. The induction of apoptosis by HL was obtained and the pathway was elucidated. Hybirid liposomes fused and accumulated in tumor cell membranes, and the apoptotic signal firstly pathed through mitochondria, caspase-9, and caspase-3, secondly through Fas, caspase-8, caspase-3 and then reached the nucleus. A good correlation between the membrane fluidity of HL and inhibitory effects of HL for tumor cells was obtained. Significantly chemotherapeutic effects were obtained using mice model of carcinoma after the treatment with HL without any drug in vivo. There were no abnormal findings on normal rats after administering HL on the basis of chronic toxicity tests. In clinical applications, prolonged survival was attained in patients with lymphoma after the intravenous injection of HL without any side effect after the approval of the bioethics committee. The membrane targeted chemotherapy with drug-free HL was established without any side effects for the first time.

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Nanoparticles of Hybrid Liposomes for the Inhibition of Breast Tumor Growth along with Apoptosis

Cited by 3 publications

References 11 publications

Clustering of Lipid Rafts in Plasma Membranes by Hybrid Liposomes for Leukemia Cells along with Apoptosis

Clustering of Lipid Rafts in Plasma Membranes by Hybrid Liposomes for Leukemia Cells along with Apoptosis

Inhibitory Effects of Hybrid Liposomes Composed of Phosphatidylcholine and Docosahexaenoic Acid on the Growth of Colon Cancer Cells along with Apoptosis and Differentiation

Chemotherapy with Hybrid Liposomes for Tumor in Relation to Fluctuation of Membranes

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