Nanoparticles. Potential for Use to Prevent Infections

Abstract

One of the major issues related to medical devices and especially urinary stents are infections caused by different strains of bacteria and fungi, mainly in light of the recent rise in microbial resistance to existing antibiotics. Lately, it has been shown that nanomaterials could be superior alternatives to conventional antibiotics. Generally, nanoparticles are used for many applications in the biomedical field primarily due to the ability to adjust and control their physicochemical properties as well as their great reactivity due to the large surface-to-volume ratio. This has led to the formation of a new research field called nanomedicine which can be defined as the use of nanotechnology and nanomaterials in diagnostics, imaging, observing, prevention, control, and treatment of diseases. For example, coverings or coatings based on nanomaterials are now seen as a promising strategy for preventing or treating biofilms formation on healthcare kits, implants, and medical devices. Toxicity, inappropriate delivery, or degradation of conventionally used drugs for the treatment of infections may be avoided by using nanoparticles without or with encapsulated/immobilized active substances. Most of the materials which are used and examined for the preparation of the nanoparticles with encapsulated/immobilized active substances or smart reactive nanomaterials with antimicrobial effects are polymers, naturally derived antimicrobials, metal-based and non-metallic materials. This chapter provides an overview of the current state and future perspectives of the nanoparticle-based systems based on these materials for prevention, control, or elimination of biofilm-related infections on urinary stents. It also addresses manufacturing conditions indicating the huge potential for the improvement of existing and development of new promising stent solutions.

Emerging evidence-based innovative approaches to control catheter-associated urinary tract infection: a review

“…A study showed that the modification of commercial PVC with methylene blue and 2 nm AuNPs upon exposure to red laser light for 4–8 min increased the photosensitivity of pathogens S. epidermis and E. coli ( Noimark et al., 2012 ). Aegle marmelos leaf extract capped with AuNPs has antimicrobial activity against various biofilm-forming organisms on urinary catheters ( Table 3 ) ( Sánchez et al., 2021 ; Filipović et al., 2022 ).…”