Nanoparticulate platinum(II) anticancer drug: Synthesis and characterization of amphiphilic cyclotriphosphazene–platinum(II) conjugates

Yu, Ji Young; Jun, Yong Joo; Jang, Soo Hyun; Lee, Hwa Jeong; Sohn, Youn Soo

doi:10.1016/j.jinorgbio.2007.07.003

Cited by 28 publications

(9 citation statements)

References 22 publications

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“…Cisplatin, cis-diamminedichloro-platinum (II), which is a typical example of a potent antioxidant, is the most widely used anticancer drug (1,7,8). Additionally, several studies have been conducted to design platinum (II) polymeric conjugates that enhance the circulation time, targeting, and release of platinum (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Effects of nanoparticulate saponin-platinum conjugates on 2,4-dinitrofluorobenzene-induced macrophage inflammatory protein-2 gene expression via reactive oxygen species production in RAW 264.7 cells

Kim

Kim²,

Lee³

et al. 2009

BMB Reports

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Nanoparticulate platinum (II) (nano Pt) is a powerful antioxidant that is widely used to scavenge reactive oxygen species (ROS).The antioxidant activity of nano Pt has gained attention as a potentially useful therapeutic for a variety of diseases including cancer and aging. In the present study, we prepared nanoparticulate saponin-Pt (II) (nano saponin-Pt) conjugates using the ethanol reduction method to enhance the permeability and retention effect of Pt. The nano saponin-Pt conjugates were found to restore the viability of approximately 40% of 2,4-dinitrofluorobenzene (DNFB)-treated RAW 264.7 cells. In addition, we found that nano saponin-Pt conjugates acted as a potent antioxidant that reduced the production of ROS

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Section: Introductionmentioning

confidence: 99%

Effects of nanoparticulate saponin-platinum conjugates on 2,4-dinitrofluorobenzene-induced macrophage inflammatory protein-2 gene expression via reactive oxygen species production in RAW 264.7 cells

Kim

Kim²,

Lee³

et al. 2009

BMB Reports

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“…Among the application studies for cancer therapy using these micellar cyclotriphosphazenes, Yu et al (2007) have reported most recently very interesting and promising platinum prodrug candidate compounds that initially form micelles in aqueous solution but aggregate further to larger soft nanoparticles with a diameter of 150 to 200 nm. The micellar Pt-cyclotriphosphazene conjugate compounds were prepared following Scheme 4.…”

Section: Synthesis and Applications Of Micellar Cyclotriphosphazenesmentioning

confidence: 99%

Poly‐ and Cyclophosphazenes as Drug Carriers for Anticancer Therapy

Sohn

Jun

2008

Polyphosphazenes for Biomedical Applications

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“…E-mail: tsedaghat@scu.ac.ir ligands based on cyclophosphazene platforms is an extremely interesting area [4][5][6][7][8][9]. An interest in these ligands comes from their ability to readily extend the small molecule chemistry to appropriate high polymers such as corresponding polyphosphazenes [2,[10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…An interest in these ligands comes from their ability to readily extend the small molecule chemistry to appropriate high polymers such as corresponding polyphosphazenes [2,[10][11][12][13]. These metal-rich phosphazene polymers have potentially desirable properties as, for example, catalysis, conductors or drug delivery systems [6,[14][15][16]. To date, many different types of cyclophosphazene-based ligands have been designed and metal ions ranging from first row transition metals to lanthanides have been involved to prepare coordination and organometallic compounds [4].…”

Section: Introductionmentioning

confidence: 99%

New organotin(IV) complexes with a potentially multi-site ligand based on the cyclotriphosphazene platform: Synthesis and spectral studies

Sedaghat

Tarassoli²,

Mojaddami³

2010

JICS

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A functionalized cyclotriphosphazene with four pyrazolyl substituents, N 3 P 3 (MeNC 2 H 4 O)(dmp) 4 where dmp = 3,5-dimethylpyrazole, has been synthesized and characterized. The reaction of this potentially multi-site coordinating cyclotriphosphazene with diorganotin(IV) dichlorides, SnR 2 Cl 2 (R = Ph, Me), leads to dinuclear [(SnPh 2 Cl 2 ) 2 {N 3 P 3 (MeNC 2 H 4 O)(dmp) 4 }] (1) and mononuclear [(SnMe 2 Cl 2 ){N 3 P 3 (MeNC 2 H 4 O)(dmp) 4 }] (2) complexes. These new compounds were characterized by elemental analysis and IR, 1 H, 31 P and 119 Sn NMR spectroscopy. On the basis of these data, in the complex 1 pyrazolylcyclotriphosphazene acts as a bis-bidentate ligand and coordinates to two SnPh 2 Cl 2 molecules via two geminal pyrazolyl nitrogen atoms. As for complex 2, coordination to one SnMe 2 Cl 2 molecule occurs through two nongeminally substituted pyrazolyl nitrogens. The 119 Sn NMR data are consistent with the increasing of coordination number of tin(IV) in solution.

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Nanoparticulate platinum(II) anticancer drug: Synthesis and characterization of amphiphilic cyclotriphosphazene–platinum(II) conjugates

Cited by 28 publications

References 22 publications

Effects of nanoparticulate saponin-platinum conjugates on 2,4-dinitrofluorobenzene-induced macrophage inflammatory protein-2 gene expression via reactive oxygen species production in RAW 264.7 cells

Effects of nanoparticulate saponin-platinum conjugates on 2,4-dinitrofluorobenzene-induced macrophage inflammatory protein-2 gene expression via reactive oxygen species production in RAW 264.7 cells

Poly‐ and Cyclophosphazenes as Drug Carriers for Anticancer Therapy

New organotin(IV) complexes with a potentially multi-site ligand based on the cyclotriphosphazene platform: Synthesis and spectral studies

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