Nanoplasmonic biochips for rapid label-free detection of imidacloprid pesticides with a smartphone

Lee, Kuang-Li; You, Meng-Lin; Tsai, Chin-Ho; Lin, En-Hung; Hsieh, Sun-Yuan; Ho, Ming-Hsun; Hsu, Ju‐Chun; Wei, Pei‐Kuen

doi:10.1016/j.bios.2015.08.010

Cited by 81 publications

(24 citation statements)

References 33 publications

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“…The sensor was also 3-times more sensitive than an SPR sensor for thiabendazole (130 pg/mL) [ 53 ]. Detection limits at the same concentration range have been also reported for SPR [ 54 ] or optical interferometry sensors [ 55 ] employed for the detection of other pesticides. Thus, the WLRS sensor developed could be placed amongst the most sensitive label-free sensors for low-molecular weight contaminants.…”

Section: System Development and Applicationsmentioning

confidence: 93%

Development and Bioanalytical Applications of a White Light Reflectance Spectroscopy Label-Free Sensing Platform

et al. 2017

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The development of a sensing platform based on white light reflectance spectroscopy (WLRS) is presented. The evolution of the system, from polymer film characterization and sensing of volatile organic compounds to biosensor for the label-free determination of either high (e.g., proteins) or low molecular weight analytes (e.g., pesticides), is described. At the same time, the passage from single to multi-analyte determinations, and from a laboratory prototype set-up to a compact device appropriate for on-site determination, is outlined. The improvements made on both the sensor and the optical set-up, and the concomitant advances in the analytical characteristics and the robustness of the assays performed with the different layouts, are also presented. Finally, the future perspectives of the system, aiming for the creation of a standalone instrument to be used by non-experts, will be discussed.

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Section: System Development and Applicationsmentioning

confidence: 93%

Development and Bioanalytical Applications of a White Light Reflectance Spectroscopy Label-Free Sensing Platform

et al. 2017

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“…Cross-reactivity assays showed that the immunosensor was affected by interference of imidaclothiz, clothianidin, and acetamiprid. Lee et al [130] developed an easy, low-cost, and label-free detection technique for qualitative and semiquantitative analysis of imidacloprid, based on an indirect competitive immunoassay. A SPR biochip combined with a simple portable imaging setup for label-free detection of pesticides was reported with a LOD of 1 ng/mL.…”

Section: Immunosensors For Pesticide Determinationmentioning

confidence: 99%

Trends and Perspectives in Immunosensors for Determination of Currently-Used Pesticides: The Case of Glyphosate, Organophosphates, and Neonicotinoids

et al. 2019

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Pesticides, due to their intensive use and their peculiar chemical features, can persist in the environment and enter the trophic chain, thus representing an environmental risk for the ecosystems and human health. Although there are several robust and reliable standard analytical techniques for their monitoring, the high frequency of contamination caused by pesticides requires methods for massive monitoring campaigns that are capable of rapidly detecting these compounds in many samples of different origin. Immunosensors represent a potential tool for simple, rapid, and sensitive monitoring of pesticides. Antibodies coupled to electrochemical or optical transducers have resulted in effective detection devices. In this review, the new trends in immunosensor development and the application of immunosensors for the detection of pesticides of environmental concern—such as glyphosate, organophosphates, and neonicotinoids—are described.

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“…Although it requires fluorescent labels and the sensitivity of the handheld version is limited, the design incorporates the necessary software to operate automatically and contemplates all the aspects to have an affordable portable POC to be used in remote areas. Another example more elaborate from the biosensor point of view implements a label-free detection experiment for pesticide detection using Ag nanoslits and transmission measurements with a smartphone [50]. Although, in principle, it is a qualitative estimation based on naked-eye colorimetric detection, it can be further optimized with image processing to get more precisely semiquantitative analysis by developing spectrometric software for the smartphone and a POC design with integrated optics.…”

Section: Breakthroughs In Multiplexing and Loc Platformsmentioning

confidence: 99%

“…An interesting example with on-site analysis has been recently provided by Lee at al., who developed a simple affordable imaging system coupled to a smartphone for the qualitative and semiquantitative detection of a pesticide (imidacloprid) [50]. The plasmonic chip is based on capped nanoslit arrays (Ag arrays coated with a 4 nm layer of Al 2 O 3 ) and the detection format is based on an indirect competitive immunoassay that allows direct detection by the naked eye (with a detectability of 1 μg l -1 ) or a more accurate analysis using image processing software in the smartphone.…”

Section: Bioanalytical and Clinical Applicationsmentioning

confidence: 99%

Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

et al. 2016

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Abstract:Motivated by the recent progress in the nanofabrication field and the increasing demand for cost-effective, portable, and easy-to-use point-of-care platforms, localized surface plasmon resonance (LSPR) biosensors have been subjected to a great scientific interest in the last few years. The progress observed in the research of this nanoplasmonic technology is remarkable not only from a nanostructure fabrication point of view but also in the complete development and integration of operative devices and their application. The potential benefits that LSPR biosensors can offer, such as sensor miniaturization, multiplexing opportunities, and enhanced performances, have quickly positioned them as an interesting candidate in the design of lab-on-a-chip (LOC) optical biosensor platforms. This review covers specifically the most significant achievements that occurred in recent years towards the integration of this technology in compact devices, with views of obtaining LOC devices. We also discuss the most relevant examples of the use of the nanoplasmonic biosensors for real bioanalytical and clinical applications from assay development and validation to the identification of the implications, requirements, and challenges to be surpassed to achieve fully operative devices.

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Nanoplasmonic biochips for rapid label-free detection of imidacloprid pesticides with a smartphone

Cited by 81 publications

References 33 publications

Development and Bioanalytical Applications of a White Light Reflectance Spectroscopy Label-Free Sensing Platform

Development and Bioanalytical Applications of a White Light Reflectance Spectroscopy Label-Free Sensing Platform

Trends and Perspectives in Immunosensors for Determination of Currently-Used Pesticides: The Case of Glyphosate, Organophosphates, and Neonicotinoids

Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

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