2018
DOI: 10.1021/acsnano.7b08051
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Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells

Abstract: The tumor microenvironment (TME) plays a critical role in tumor initiation, progression, invasion, and metastasis. Therefore, a therapy that combines chemotherapeutic drugs with a TME modulator could be a promising route for cancer treatment. This paper reports a nanoplatform self-assembled from a hyaluronic acid (HA)-paclitaxel (PTX) (HA-PTX) prodrug and marimastat (MATT)-loaded thermosensitive liposomes (LTSLs) (MATT-LTSLs) for the dual targeting of the TME and cancer cells. Interestingly, the prodrug HA-PTX… Show more

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Cited by 201 publications
(136 citation statements)
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References 70 publications
(118 reference statements)
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“…[21][22][23][24][25][26] However, combination immu notherapy suffers from the distinct chemophysical properties and incon sistent pharmacokinetic profiles of the different immune modulators. [29,30] In recent years, excip ientfree nanomedicines have attracted extensive attention for highly efficient dug delivery. [27,28] Moreover, excipients are essential for preparing drugloaded nanoparticles, which cause unsatisfied drug loading ratios.…”
mentioning
confidence: 99%
“…[21][22][23][24][25][26] However, combination immu notherapy suffers from the distinct chemophysical properties and incon sistent pharmacokinetic profiles of the different immune modulators. [29,30] In recent years, excip ientfree nanomedicines have attracted extensive attention for highly efficient dug delivery. [27,28] Moreover, excipients are essential for preparing drugloaded nanoparticles, which cause unsatisfied drug loading ratios.…”
mentioning
confidence: 99%
“…Under acidic conditions of lysozymes and cell lysates, small nanoparticles further dissociated and released the entrapped drug, which generated high ROS and activated p53 and mitogen activated protein kinase (MAPK) pathways to induce tumor cell apoptosis. Very recently, nanocomplex self‐assembled from HA‐conjugated PTX and marimastat‐loaded thermosensitive liposome has been programed to dually target the tumor microenvironment and tumor cells (Figure B) . Triggered by mild hyperthermia, nanocomplex rapidly released the cargoes into the tumor microenvironment.…”
Section: Positive Targetingmentioning
confidence: 99%
“…B) Schematic illustration of preparing nanomedicine and the proposed mechanism for metastatic breast tumor therapy. Reproduced with permission . Copyright 2018, American Chemical Society.…”
Section: Positive Targetingmentioning
confidence: 99%
“…In our previous reports, we had demonstrated well that marimastat (MATT) was able to inhibit the MMPs and the resulted metastasis effectively via mimicking the substrate of the MMPs to work with MMPs in a competitive and reversible pattern . MATT is of low toxicity toward cancer cells.…”
Section: Introductionmentioning
confidence: 99%
“…However, its combined use with cytotoxicity agents, for example, paclitaxel (PTX) which is a potent antitumor drug acting via targeting the tubulin, can compensate the drawback and treat metastatic cancer. Previously by assembling prodrug polymer‐PTX and MATT‐loaded nanoparticles, coloaded nanocomplexes were designed to treat metastatic cancer in a 4T1 tumor‐bearing model . Although effective antitumor efficacy was demonstrated, the preparation of such complexes was too complicated to be characterized and to achieve the clinical transition.…”
Section: Introductionmentioning
confidence: 99%