Nanoporous metal-organic framework Cu2(BDC)2(DABCO) as an efficient heterogeneous catalyst for one-pot facile synthesis of 1,2,3-triazole derivatives in ethanol and evaluating antimicrobial activity of the novel derivatives

Abstract

Solvent-free ball-milling synthesized porous metal-organic framework Cu2(BDC)2(DABCO) (BDC: benzene-1,4-dicarboxylic acid, DABCO: 1,4-diazabicyclo [2.2.2]octane) has been proved to be a practical catalyst for facile and convenient synthesis of 1,2,3-triazole derivatives via multicomponent reaction of terminal alkynes, benzyl or alkyl halides, and sodium azide in ethanol. Avoidance of usage and handling of hazardous organic azides, using ethanol as an easily available solvent, and simple preparation and recycling of the catalyst make this procedure a truly scale-up-able one. The high loading of copper ions in the catalyst leads to e cient catalytic activity and hence, its low-weight usage in reaction. The catalyst was recycled and reused several times without signi cant loss of its activity. Furthermore, novel derivatives were examined to investigate their potential antimicrobial activity via microdilution method.

2-(Aminomethyl)benzimidazole/Cu2+ immobilized on Fe3O4@SiO2: a convenient magnetic nanocatalyst for click reaction of aryl iodide/benzyl halide, sodium azide and terminal alkyne

“…Corresponding peaks of Fe3O4 in XRD were observed at 2θ=30.0, 35.0, 42.0, 52.0, 56.0, and 62.0, which are similar to the pattern of the reported Fe3O4 nanoparticles before. 19,30 Fig . 3.…”

A novel cubic Zn‐citric acid‐based MOF as a highly efficient and reusable catalyst for the synthesis of pyranopyrazoles and 5‐substituted 1H‐tetrazoles

“…[26][27][28][29][30][31][32] During the last two decades, a large number of metal-organic frameworks (MOFs) have been reported in the literature; among them, Zn-based MOF with a very large surface area as well as high thermal resistance has drawn great attention due to its exceptional tunability and functionality and also its potential applications in many fields, especially in the catalytic synthesis of various organic and bioorganic molecules via organic transformations with scientific popularity. [33][34][35][36] In addition, due to the porous structure, the surface of Zn-based MOFs tends to greatly profit from generating the intimate interaction interface between Zn species and ligand. [37][38][39][40] Recently, some specific efforts have been made to design effective traditional-based MOF catalysts based on expensive metals.…”

Synthesis of (E)-2-(1H-tetrazole-5-yl)-3-phenylacrylenenitrile Derivatives Under Green Conditions Catalyzed by New Thermally Stable Magnetic Periodic Mesoporous Ognosilica Embedded With ZnO Nanoparticles

“…In 2001, Sharpless introduced "Click Chemistry" as a set of reactions with speci c characteristics such as: modular, wide-range, high-yield only to produce a harmless byproduct that can be removed by non-chromatographic separation techniques [1][2][3][4][5][6] . Synthesis of tetrazole derivatives can be achieved in an eco-friendly approach such as using green models in particular water as solvent, room temperate, easy separation, low cost andwith good to excellent yields [7][8][9][10][11] . 1,3-dipolar cycloaddition reactions are one of the most popular "click chemistry" reactions.…”