Nanoporous titanium implant surface promotes osteogenesis by suppressing osteoclastogenesis via integrin β1/FAKpY397/MAPK pathway

He, Yide; Li, Zhe; Ding, Xin; Xu, Boya; Wang, Jinjin; Li, Yang; Chen, Fanghao; Meng, Fanhui; Song, Wen; Zhang, Yumei

doi:10.1016/j.bioactmat.2021.06.033

Cited by 44 publications

(33 citation statements)

References 66 publications

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“…Recent studies have reported that Itgb1 shares a regulatory function with MAPK pathway signaling in osteoclastogenesis. Osteoclastogenesis is suppressed by the integrin β1/ FAKpY397/MAPK pathway on a titanium implant surface (23). In our present study, a KEGG enrichment analysis of OVX mice revealed that miRNAs were mainly related to the MAPK pathway, underlying a potential miR-134-5p/Itgb1 network involved in osteoclast differentiation through the MAPK pathway.…”

Section: Discussionsupporting

confidence: 52%

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miR-134-5p inhibits osteoclastogenesis through a novel miR-134-5p/Itgb1/MAPK pathway

Huang¹,

Wang²,

Wang³

et al. 2022

Journal of Biological Chemistry

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Section: Discussionsupporting

confidence: 52%

“…Moreover, the MAPK pathway has been proven to be crucial for bone metabolism and osteoclast differentiation (23). p38 and Erk and their phosphorylated forms p-p38 and p-Erk in BMMs transfected with agomir or antagomir alone or transduced with si Itgb1 or its negative control were detected.…”

Section: Mir-134-5p Suppresses Osteoclast Differentiation By Targetin...mentioning

confidence: 99%

miR-134-5p inhibits osteoclastogenesis through a novel miR-134-5p/Itgb1/MAPK pathway

Huang¹,

Wang²,

Wang³

et al. 2022

Journal of Biological Chemistry

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“…The MAPK signaling pathway, which contains ERKs, JNKs and P38, is known to play a critical role in cell function and has been verified as a driving factor for osteoclast maturity ( He et al, 2022 ). Additionally, many scientists have previously confirmed that the MAPK cascade is related to the occurrence of osteoclastic autophagy ( Xu et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages

Tao

Yang

et al. 2022

Front. Pharmacol.

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Senile osteoporosis (SOP) is a systemic bone disease that is significantly associated with age and eventually leads to deteriorated bone strength and increased fracture risk. Urolithin A (Uro-A) is a gut microbiome-derived compound that is mainly produced from pomegranates and some nuts. Uro-A has attracted great attention in recent years in view of its protective effects on aging-related diseases, including muscle dysfunction, kidney disease and knee injury. However, its protective influence and possible mechanisms in senile osteoporosis remain unclear. Our study describes the beneficial effect of Uro-A on bone marrow macrophages (BMMs). The in vitro results demonstrated that Uro-A inhibited receptor activator for nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis in BMMs in a concentration-dependent manner. Uro-A significantly reduced the expression of osteoclast-related genes and bone resorption. Mechanistically, we found that the autophagy ability of BMMs was significantly enhanced in the early stage of Uro-A treatment, accompanied by the activation of LC3 and Beclin 1. At the same time, this enhanced autophagy activity was maintained until the later stage after stimulation with RANKL. Furthermore, we found that the MARK signaling pathway was blocked by Uro-A treatment. In a mouse model of aging, Uro-A effectively inhibited bone loss in the proximal femur, spine and tibia of aging mice. These results indicated that Uro-A is a robust and effective treatment for preventing senile osteoporosis bone loss.

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“…Among them, 80 nm TiO 2 coating surfaces may possess the weakest inflammatory reaction with lessened mRNA expression and protein secretion of MCP-1, MIP-1α, IL-1β, IL-6 and TNF-α. 94,95 In addition, gold nanoparticle (AuNP) coatings with an appropriate scale of topography (20–30 nm) were nontoxic to mice and exhibited superior anti-inflammatory effects, in which the cell shapes of the macrophage changed from a more rounded shape into a more elongated spindle shape with apparent pseudopodia. AuNP coatings also precisely induced macrophage polarization from pro-inflammatory M1 toward the anti-inflammatory M2 extreme.…”

Section: Engineering Nanomaterials For Immunomodulation and Bone Rege...mentioning

confidence: 99%

Novel insights into nanomaterials for immunomodulatory bone regeneration

Cui

et al. 2022

Nanoscale Adv.

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Nanoporous titanium implant surface promotes osteogenesis by suppressing osteoclastogenesis via integrin β1/FAKpY397/MAPK pathway

Cited by 44 publications

References 66 publications

miR-134-5p inhibits osteoclastogenesis through a novel miR-134-5p/Itgb1/MAPK pathway

miR-134-5p inhibits osteoclastogenesis through a novel miR-134-5p/Itgb1/MAPK pathway

Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages

Novel insights into nanomaterials for immunomodulatory bone regeneration

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