Nanoprobes for in vitro diagnostics of cancer and infectious diseases

Chi, Xiaoqin; Huang, Dengtong; Zhao, Zhenghuan; Zhou, Zijian; Yin, Zhenyu; Gao, Jinhao

doi:10.1016/j.biomaterials.2011.09.032

Cited by 133 publications

(105 citation statements)

References 128 publications

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“…The materials in nanostructured form are the excellent candidates as probes because they can achieve high response to very small targets in practical conditions. Nanomaterials (e.g., nanoparticles, nanowires, nanotubes, and even Nanodevices) have been explored in many biomedical applications (e.g., biosensing, biological separation, molecular imaging, and anticancer therapy) because their novel properties and functions differ drastically from the bulk counterparts (Chi et al, 2012).…”

Section: Iron Oxide Nanoparticles (Magnetic Nanoparticles)mentioning

confidence: 99%

Magnetite (Fe3 O4 ) nanoparticles: Are they really safe?

Ramírez¹

2015

lgr

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Manuscrito recibido el 21 de noviembre de 2014. Aceptado, tras revisión, el 4 de junio de 2015. AbstractIron oxide nanoparticles and in particular Fe3O4 Nanoparticles are new materials used in biotechnology and nanotechnology, Food and drugs administration has approved several coated and bare Iron oxide nanoparticless and they are actually used in biomedical applications as: Magnetic Resonance Imaging contrast agent, Thermotherapy agent, Drug carrier for cancer treatments, and so on.All this applications bring risk of: a single exposure, workplace exposure, incidental and environmental release and potential long life use. In this regard, iron oxide nanoparticles toxic effect, in particular neurotoxicity is not well known and it needs to be assessed.The aim of this review is to present several iron oxide nanoparticles in vitro and in vivo studies that reflex Fe3O4 actual an overview toxicological profile.

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Section: Iron Oxide Nanoparticles (Magnetic Nanoparticles)mentioning

confidence: 99%

Magnetite (Fe3 O4 ) nanoparticles: Are they really safe?

Ramírez¹

2015

lgr

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“…A way to solve this problem relies in the synthesis of Gdbased paramagnetic NPs [68] , such as Ln 2 O 3 , GdF 3 , and GdPO 4 [26,69,70] , which yield high magnetic moments because of the abundance of paramagnetic ions on their surfaces.…”

Section: T 1 Np-based Contrast Agentsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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“…177 Nanomaterial-based probes involve the use of nanotechnology to meet the demands of in vitro diagnostics for increased sensitivity and rapid detection from complex environmental systems. 178 NPs labeled in vivo signaling moiety offer better molecularly targeted specificity than conventional imaging techniques. Various combinations of multifunctional NPs have been established with imaging agents like radioisotopes, lanthanides, or fluorophores.…”

Section: Nanotechnology-based Approaches In Cancer Diagnosticsmentioning

confidence: 99%

“…178 NP probes with molecularly targeted recognition agents might provide information on the presence, relative abundance, and distribution of cancer signatures and markers associated with the tumor microenvironment. 13 Because of their unique properties, QDs are one of the well-established NPs that cover applications such as cellular imaging, immunoassays, in vivo imaging, and sensing.…”

Section: Nanotech In Anticancer Researchmentioning

confidence: 99%

“…This ultrasensitive nanoprobe based on the FRET system had the capability to detect low concentrations of DNA, which have great potential to diagnose DNA mutations of tumor cells in clinical samples. 178 Methylation-specific QD-FRET offers great promise for its translational use in early cancer diagnosis, prognostic assessment of tumor behavior, and monitoring response to therapeutic agents in clinical samples. 186 QD-based bioluminescence resonance energy transfer (BRET) conjugated to bioluminescent proteins uses biochemical energy to excite fluorophores and offers additional advantages over FRET system for various bioanalyses.…”

Section: Nanotech In Anticancer Researchmentioning

confidence: 99%

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Nanotechnology-based approaches in anticancer research

Jabir¹,

Tabrez²,

Ashraf³

et al. 2012

IJN

149

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Cancer is a highly complex disease to understand, because it entails multiple cellular physiological systems. The most common cancer treatments are restricted to chemotherapy, radiation and surgery. Moreover, the early recognition and treatment of cancer remains a technological bottleneck. There is an urgent need to develop new and innovative technologies that could help to delineate tumor margins, identify residual tumor cells and micrometastases, and determine whether a tumor has been completely removed or not. Nanotechnology has witnessed significant progress in the past few decades, and its effect is widespread nowadays in every field. Nanoparticles can be modified in numerous ways to prolong circulation, enhance drug localization, increase drug efficacy, and potentially decrease chances of multidrug resistance by the use of nanotechnology. Recently, research in the field of cancer nanotechnology has made remarkable advances. The present review summarizes the application of various nanotechnology-based approaches towards the diagnostics and therapeutics of cancer.

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Nanoprobes for in vitro diagnostics of cancer and infectious diseases

Cited by 133 publications

References 128 publications

Magnetite (Fe3 O4 ) nanoparticles: Are they really safe?

Magnetite (Fe3 O4 ) nanoparticles: Are they really safe?

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Nanotechnology-based approaches in anticancer research

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