Nanoscale Manipulation of Prednisolone as Electroactive Configuration Using Molecularly Imprinted‐Multiwalled Carbon Nanotube Paste Electrode

Rezaei, Behzad; Mirahmadi-Zare, Seyede Zohreh

doi:10.1002/elan.201100261

Cited by 21 publications

(2 citation statements)

References 44 publications

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“…Finally, it is worth to mention that is the first‐time that MSUD samples from clinical patients are studied using electrochemical sensors adding a valuable information to the results found. Although, other reports showed better LODs than those obtained in the current work for branched‐chain amino acids detection, the analytical capabilities of the v‐NiNWs sensors were excellent not only for the fast and reliable early MSDU diagnosis but also for future POCs developments because of their high inherent versatility and simplicity.…”

Section: Resultsmentioning

confidence: 97%

Electrochemical On‐site Amino Acids Detection of Maple Syrup Urine Disease Using Vertically Aligned Nickel Nanowires

2018

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In this work, vertically aligned nickel nanowires‐based electrochemical sensors (v‐NiNWs) for rapid detection of branched‐chain amino acids for a non‐invasive screening of maple syrup urine disease (MSUD), are proposed. v‐NiNWs meet the required features for decentralized clinical diagnosis: easy to operate, fast sensor response and short total analysis times (5 min), as well as low sample consumption (250 ml). The analytical characteristics (for leucine as representative branched‐chain amino acid in MSUD) such as detection limit (8 μM) and linear range (25–700 μM which includes as midpoint the amino acids cut‐off of 250 μM) clearly showed the suitability of v‐NiNWs as new and disposable analytical tool for rapid screening of branched‐chain amino acids in MSUD because of their high capabilities for reliable differentiation between healthy and ill clinical sample profiles. In addition, intra and inter‐electrodes repeatability were excellent with values of RSD≤4 and 9 %, respectively (n=5). This approach opens novel avenues not only for ultrafast diagnosis of MSUD using miniaturized and even disposable devices but also for a future point‐of‐care testing; providing novel alternatives for on‐site decentralized monitoring.

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Section: Resultsmentioning

confidence: 97%

Electrochemical On‐site Amino Acids Detection of Maple Syrup Urine Disease Using Vertically Aligned Nickel Nanowires

2018

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“…When MWCNTs are used as electrode materials, they present the outstanding ability to promote electron transfer reactions due to the nanometer dimensions of the MWCNTs, the electronic structure, and the topological defects present on the tube surfaces [46][47][48]. Therefore, MWCNTs have been successfully used in the preparation of chemical or electrochemical sensors for a wide range of electroactive species [49][50][51][52][53][54][55]. Usually, the MWCN Ts were immobilized on to the electrode surfaces by using a MWCNT solution as the dispersing medium.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of electrochemical sensor based on molecularly imprinted polymer and nanoparticles for determination trace amounts of morphine

Rezaei

Foroughi-Dehnavi

Ensafi

2015

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A simple and rapid electrochemical method developed for the detection of trace amounts of morphine (MO) at the surface of modified pencil graphite electrode (PGE) with multiwall carbon nanotubes (MWCNTs), molecularly imprinted polymer (MIP), and gold nanoparticles (AuNPs).Various types of electrochemical methods containing cyclic voltammetry (CV), square wave voltammetry (SWV), and electrochemical impedance spectroscopy (EIS) were employed to probe the characteristics of the constructed electrode toward morphine. After optimization of several effective parameters, the calibration curve by SWV was linear in two linear domains, over the range of 0.008 to 5 μmol L −1 vs. Ag/AgCl, and the detection limit was 2.9 nM. The relative standard deviation (RSD) for six replicate determinations of 0.05 μmol L −1 MO was found to be 2.57 % (S/N = 3). Finally, the ability of the electrochemical sensor was successfully applied for MO determination in real samples such as human urine and plasma.

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A Novel Method of High Sensitive Determination of Prednisolone on Renewable Mercury Film Silver Based Electrode

2015

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[a] 1IntroductionGlucocorticoids are group of important medications with wide variety of use,m ainly due to their anti-inflammatory and immunosuppressive properties.H uman body produces natural corticoids which are necessaryf or propers ecretion of other hormones and keeping homeostasis. However, affecting the balance of adrenalh ormones excretion may cause diseases connected with necessity of using their synthetic analogs in very little and controlled doses.T aking drugs containingc orticoids is connected with the risk of serious adversee ffects,t hus quality control of medications consisting this group of active substances shouldb ev ery precise [1,2].Prednisolone ((11b)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione [8].P rednisolone derivative is also used in ophthalmologya sacontent of eye drops used to reducea llergic reactionsa ffecting eyes, such as swellinga nd itching [ 9,10].D ue to its immunosuppressive properties is also widely use after organ transplantation [11] and as ah ormone substitution for patients unable to produce proper amounts of corticosteroids on its own [12].L ong term usage of this corticoid may cause serious side effectsl ike gaining weight, high blood pressure,m usclew eakness,o steoporosis,h igh glucose level in body fluids or mentalh ealth problems [13][14][15][16].Numerous studies have been presented withd ifferent prednisolone determination methods including spectroscopy [17],s pectrophotometry [18,19],g as chromatography [20][21][22],c hemiluminescence [23] and high performance liquid chromatography (HPLC) coupled with various detector [24][25][26][27].H owever these methods generate lots of chemical wastesa nd also require time consuming sample preparation connected with risk of its contamination.S uch inconveniences can be eliminated using electrochemical methods,w hich provide high sensitivity,l ow limit detectiona nd simple procedure of sample preparation.C lassical polarography [28,29] and different voltammetry techniques were used for prednisolone determination.R ecently,t wo voltammetric methodsw ere developed for the analyte determinationi nd rug samples based on oxidation of prednisolone at glassy carbon electrode [30] . One of the methodso fa chieving high sensitivity in voltammetry is development in the working electrode constructionf ield. Va rious typeso fm etal film electrodes were constructed recently.A mongt hem lead, gallium and mercury were most frequently used [35][36][37].I nteresting solution of renewable mercury film electrode was proposed by Baś and Kowalski[ 38].W ith the renewable Abstract:F ast and sensitive method of prednisoloned eterminationa tr enewable mercury film electrodeu sing differentialp ulse adsorptive stripping voltammetry (DPAdSV) was successfully developed. Thee ffects of various factors such as:p reconcentration potential and time, pulse height, step potential and supporting electrolyte composition were optimized.Alinear voltammetric response for analyte was obtained in the concentration), with ad etectionl imit of 0.01 mmolL À1 ...

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Nanoscale Manipulation of Prednisolone as Electroactive Configuration Using Molecularly Imprinted‐Multiwalled Carbon Nanotube Paste Electrode

Cited by 21 publications

References 44 publications

Electrochemical On‐site Amino Acids Detection of Maple Syrup Urine Disease Using Vertically Aligned Nickel Nanowires

Electrochemical On‐site Amino Acids Detection of Maple Syrup Urine Disease Using Vertically Aligned Nickel Nanowires

Fabrication of electrochemical sensor based on molecularly imprinted polymer and nanoparticles for determination trace amounts of morphine

A Novel Method of High Sensitive Determination of Prednisolone on Renewable Mercury Film Silver Based Electrode

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