Nanoscale Metal Particles as Nanocarriers in Targeted Drug Delivery System

Abstract

In the recent years, noble metal particles such as gold (Au) and silver (Ag) have been used progressively as efficient and safe nanoscale drug carriers in treating malignant as cites of cancerous cells. These single crystal structures of functionalised therapeutic particles with the size less than 100 nm in diameter had proven offered an excellent function to modulate the oxidative stress and toxicity at affected membrane cells particularly to achieve the site-specific delivery of drugs. This mini-review will highlight the current advances of Au and Ag nanoscale particles as smart chemotherapeutic molecule carriers to these malignancies in impeding cancer cell activities locally. The paper also reviewed valuable insights of their efficacy in maintaining and precisely control the drugs release level within the therapeutic windows.

Multiscale Modeling of Bio-Nano Interactions of Zero-Valent Silver Nanoparticles

“…Alternatively, cell death can be triggered by the drug which was preloaded to the NP (Figure ). In this scenario, the NP acts as a vehicle delivering the antitumor reagent directly to the target (a nanocarrier , ).…”

Recent Development of Nanomaterials for Transdermal Drug Delivery

“…Size of PLGA NPs can be tailored to suit particular drug delivery applications [ 121 ]. Smaller nanoparticles (<100 nm) deliver drugs to cells or tissues [ 122 ], while larger nanoparticles (>500 nm) deliver drugs to targeted organs or the entire body [ 123 ]. According to one reference [ 124 ], nanoprecipitation of PLGA NPs alters their sizes, causing increased intracellular delivery.…”

Methods for Reducing the Toxicity of Metal and Metal Oxide NPs as Biomedicine

“…The use of nanoparticles obtained by biological methods also increases the biocompatibility of particles. In addition, due to the small size of the nanoparticles, they help active substances pass through biological barriers and release the drug in the right place [31].…”

“…These materials showed not only a lack of cytotoxicity, but also acted synergistically in combination with medicinal substances, which further created opportunities for their use in the treatment of cancer. For example, selenium nanoparticles (Se NPs) work well as carriers of doxorubicin (DOX) due to their good antioxidant activity and lack of toxicity due to the natural presence of selenium in the human body [31]. Examples of effective carriers are galactose modified selenium nanoparticles (GA-SeNPs) loaded with DOX and used in the treatment of hepatocellular carcinoma (HCC).…”