Nanoshells for Drug Delivery

Villiers, Melgardt M. de; Lvov, Yuri

doi:10.1002/9783527610419.ntls0118

Cited by 8 publications

(7 citation statements)

References 75 publications

(117 reference statements)

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“…Our results might significantly contribute to the continuum theory of multi-component liquids, since controlled pattern formation in these systems is of increasing importance in several practical applications. For instance, surfactant controlled nanoshell formation opened a new chapter in targeted drug delivery [33]. Another crucial field is energy: a controlled emulsion → emulsion transition in the CO 2 /water/heavy crude oil system would result in an efficient and environmentally sound combination of CO 2 storage and Enhanced Oil Recovery [34,35].…”

Section: Discussionmentioning

confidence: 99%

Phase-field theory of multicomponent incompressible Cahn-Hilliard liquids

2016

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In this paper a generalization of the Cahn-Hilliard theory of binary liquids is presented for multi-component incompressible liquid mixtures. First, a thermodynamically consistent convectiondiffusion type dynamics is derived on the basis of the Lagrange multiplier formalism. Next, a generalization of the binary Cahn-Hilliard free energy functional is presented for arbitrary number of components, offering the utilization of independent pairwise equilibrium interfacial properties. We show that the equilibrium two-component interfaces minimize the functional, and demonstrate, that the energy penalization for multi-component states increases strictly monotonously as a function of the number of components being present. We validate the model via equilibrium contact angle calculations in ternary and quaternary (4-component) systems. Simulations addressing liquid flow assisted spinodal decomposition in these systems are also presented.

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Section: Discussionmentioning

confidence: 99%

Phase-field theory of multicomponent incompressible Cahn-Hilliard liquids

2016

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“…In our view and as described in this review, classification of heat treatment and drug delivery under the category of hyperthermia is extremely important in order to unleash the advantages of the combination. The possibilities to create core-shell magnetic nanomaterials and nanoshells, especially the opportunities to utilize layer-by-layer self-assembly approaches, [19, 35 } will lead to innovative designs for different types of hyperthermia-based treatments. Such combination offers multi-therapeutic modalities in a single treatment.…”

Section: 0 Conclusionmentioning

confidence: 99%

“…Polymers or surfactant stabilized MNPs are not considered truly as core-shell MNPs under this definition. Since there are a large number of review articles covering synthesis of core-shell MNPs, especially those using layer-by-layer self-assembly approach, [35] we will only make references to their synthesis where the materials have been synthesized specifically for the purpose of hyperthermia-based treatment or controlled drug release. We will dwell on targeted hyperthermia and spatiotemporal drug delivery with potential opportunities for cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery

Kumar

Mohammad

2011

Advanced Drug Delivery Reviews

1,452

874

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Previous attempts to review the literature on magnetic nanomaterials for hyperthermia-based therapy focused primarily on magnetic fluid hyperthermia (MFH) using mono metallic/metal oxide nanoparticles. The term “Hyperthermia” in the literature was also confined only to include use of heat for therapeutic applications. Recently, there have been a number of publications demonstrating magnetic nanoparticle-based hyperthermia to generate local heat resulting in the release of drugs either bound to the magnetic nanoparticle or encapsulated within polymeric matrices. In this review article, we present a case for broadening the meaning of the term “hyperthermia” by including thermotherapy as well as magnetically modulated controlled drug delivery. We provide a classification for controlled drug delivery using hyperthermia: Hyperthermia-based controlled Drug delivery through Bond Breaking (DBB) and Hyperthermia-based controlled Drug delivery through Enhanced Permeability (DEP). The review also covers, for the first time, core-shell type magnetic nanomaterials, especially nanoshells prepared using layer-by-layer self-assembly, for the application of hyperthermia-based therapy and controlled drug delivery. The highlight of the review article is to portray potential opportunities in the combination of hyperthermia-based therapy and controlled drug release paradigms for successful application in personalized medicine.

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“…Based on electrostatic interaction between adsorbing layers, LbL shell preparation does not require harsh conditions to interlock different components together in the same coating. As an advantage, its architecture in the direction normal to the core surface is decided beforehand [3–5]. The possibility of scaling-down and combining with different core preparation techniques makes LbL assembly a highly promising approach for nanomedicine applications.…”

Section: Polyelectrolyte Coated Drug Nanocarriersmentioning

confidence: 99%

Spherical and tubule nanocarriers for sustained drug release

Shutava

Fakhrullin

Lvov

2014

Current Opinion in Pharmacology

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We discuss new trends in Layer-by-Layer (LbL) encapsulation of spherical and tubular cores of 50–150 nm diameter and loaded with drugs. This core size decrease (from few micrometers to a hundred of nanometers) for LbL encapsulation required development of sonication assistant non-washing technique and shell PEGylation to reach high colloidal stability of drug nanocarriers at 2–3 mg/mL concentration in isotonic buffers and serum. For 120–170 nm spherical LbL nanocapsules of low soluble anticancer drugs, polyelectrolyte shell thickness controls drug dissolution. As for nanotube carriers, we concentrated on natural halloysite clay nanotubes as cores for LbL encapsulation that allows high drug loading and sustains its release over tens and hundreds hours. Further drug release prolongation was reached with formation of the tube-end stoppers.

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Nanoshells for Drug Delivery

Abstract: The sections in this article are Introduction Metallic Nanoshells Synthesis of the Nanoshells Application in Nanomedicine Nanoshells Formed by Polyion E ‐ Lb L Self‐assembly Preparation of … Show more

Cited by 8 publications

References 75 publications

Phase-field theory of multicomponent incompressible Cahn-Hilliard liquids

Phase-field theory of multicomponent incompressible Cahn-Hilliard liquids

Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery

Spherical and tubule nanocarriers for sustained drug release

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