Nanosilver-Decorated Biodegradable Mesoporous Organosilica Nanoparticles for GSH-Responsive Gentamicin Release and Synergistic Treatment of Antibiotic-Resistant Bacteria

Li, Haijun; Li, Dongbei; Chen, Fangman; Yang, Chao; Li, Xiaogai; Yuan, Zhangfu; Hua, Chunlan; Ma, Xiaoxu; Zhao, Xin; Shao, Dan; Wang, Yingshuai; Ming, Liang

doi:10.2147/ijn.s315067

Cited by 18 publications

(5 citation statements)

References 44 publications

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“…Very recently, Li et al reported an alternative approach consisting of the design of GSH-degradable mesoporous organosilica NPs (MONs) for the co-delivery of gentamicin (GEN) and silver ions for the synergistic treatment of antibiotic-resistant bacteria. 767 In this study, the authors prepared disulfide-bridged Ag-MONs using a one-pot sol–gel method that required the addition of tannic acid, which acted not only as a non-surfactant template for the formation of MONs but also as a reductant for the formation of nanoAg. The subsequent loading of GEN afforded the Ag-MONs@GEN nanoplatform.…”

Section: Potential Biomedical Treatments Using Msnsmentioning

confidence: 99%

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

et al. 2022

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Section: Potential Biomedical Treatments Using Msnsmentioning

confidence: 99%

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

et al. 2022

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“…13, 331. doi:10. /s11671-018-2753 Wang, H., Zheng, X., Zhang, Y., Huang, J., Zhou, W., Li, X., et al (2021). The endocrine role of bone: Novel functions of bone-derived cytokines.…”

Section: Fundingmentioning

confidence: 99%

Bioactive Materials for Disease Diagnosis and Therapy

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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“…Until recent years, scientists attempted to construct GSH-responsive nanomaterials via unstable disulfide bonds. Li et al (2021b) developed mesoporous organosilica NPs to deliver Ag and gentamicin. In order to prevent the uncontrolled release of antibiotics and Ag from causing toxicity to normal tissues, the authors introduced disulfide bonds to modify this nanocomposite.…”

Section: Applications Of Precise Antibacterial Therapeutics Based On ...mentioning

confidence: 99%

Precise antibacterial therapeutics based on stimuli-responsive nanomaterials

Wu,

Nie,

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Bacterial infection refers to the process in which bacteria invade, grow, reproduce, and interact with the body, ultimately causing a series of pathological changes. Nowadays, bacterial infection remains a significant public health issue, posing a huge threat to human health and a serious financial burden. In the post-antibiotic era, traditional antibiotics are prone to inducing bacterial resistance and difficulty in removing bacterial biofilm. In recent years, antibacterial therapy based on nanomaterials has developed rapidly. Compared with traditional antibiotics, nanomaterials effectively remove bacterial biofilms and rarely result in bacterial resistance. However, due to nanomaterials’ strong permeability and effectiveness, they will easily cause cytotoxicity when they are not controlled. In addition, the antibacterial effect of non-responsive nanomaterials cannot be perfectly exerted since the drug release property or other antibacterial effects of these nano-materials are not be positively correlated with the intensity of bacterial infection. Stimuli-responsive antibacterial nanomaterials are a more advanced and intelligent class of nano drugs, which are controlled by exogenous stimuli and microenvironmental stimuli to change the dosage and intensity of treatment. The excellent spatiotemporal controllability enables stimuli-responsive nanomaterials to treat bacterial infections precisely. In this review, we first elaborate on the design principles of various stimuli-responsive antibacterial nanomaterials. Then, we analyze and summarizes the antibacterial properties, advantages and shortcomings of different applied anti-bacterial strategies based on stimuli-responsive nanomaterials. Finally, we propose the challenges of employing stimuli-responsive nanomaterials and corresponding potential solutions.

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Nanosilver-Decorated Biodegradable Mesoporous Organosilica Nanoparticles for GSH-Responsive Gentamicin Release and Synergistic Treatment of Antibiotic-Resistant Bacteria

Cited by 18 publications

References 44 publications

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

Bioactive Materials for Disease Diagnosis and Therapy

Precise antibacterial therapeutics based on stimuli-responsive nanomaterials

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