Nanosized dispersions based on chitosan and NaPSS

Lima, C.R.M. de; Pereira, M.R.; Fonseca, J. L. C.

doi:10.1007/s10965-017-1214-7

Cited by 7 publications

(1 citation statement)

References 54 publications

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“…Additionally, the ionic strength of the solution also played a role in the particle size and stability of the PECs, with higher ionic strength resulting in smaller particle sizes. (10)(11)(12) chitosan exhibits bioadhesive and permeation-enhancing properties that make it an ideal carrier for drug delivery to the brain via the nasal route. These properties allow for improved absorption of drugs across the nasal mucosa and enhanced delivery to the brain.…”

Section: Introductionmentioning

confidence: 99%

Design, Optimization and Evaluation of Intranasal Nanotherapeutic of Atypical Antipsychotic Drug

2023

ecb

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Objective:The current study manifests the successful optimization and delivery of chitosan nanoparticles utilizing the nasal route to overcome inherent issues of ziprasidone hydrochloride, an atypical antipsychotic drug to curtail its bioavailability problems. Materials & Methods:Chitosan nanoparticles were prepared by ionic gelation technique and optimized using Box-Behnken design. In vitro drug release kinetics and ex vivo nasal permeation potential were determined. Results & Discussion:Chitosan nanoparticles exhibited a mean particle size of 153.8 ± 13.3 nm, a mean polydispersity index of 0.433 ± 0.15; an Entrapment Efficiency of 87.3 ± 3.62%, and a Drug loading capacity of 8.7 ± 0.25%. Transmission electron microscopy examinations revealed spherical particle size with uniform drug distribution. The physicochemical

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Section: Introductionmentioning

confidence: 99%