Nanostructural Mechanism of Modifying Adaptation of Proteoglycan Systems of Biological Tissues and Mucus

Vazina, A.A.; Vasiliev, V.D.; Vasilieva, A. A.; Vasilchenko, V. A.; Gichka, S. G.; Zabelin, A. V.; Кваша, М. С.; Korneev, V. N.; Kulipanov, G.N.; Lanina, N. F.; Marinsky, G. S.; Podpryatov, S. E.; Подпрятов, С. С.; Shelestov, V.M.; Paton, B. E.

doi:10.1134/s1063774518070258

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…Результаты исследований показывают, что в норме марганец, поступивший в пищеварительный тракт, является необходимым элементом не только во внутренней среде организма, но и на уровне энтеральной среды, то есть до момента всасывания. Вероятно, фиксируясь специфическими лигандами гликопротеинов, марганец концентрируется в плотной эндогенной фракции химуса, участвуя в формировании упорядоченной наноструктуры энтероплазмы [8], которая в норме имеет ограниченное количество мест фиксации для марганца вследствие генетически детерминированной гомеостатичной модели. При избытке в рационе марганца обнаруживается увеличение элемента в крови, оттекающей от желудка и 12-перстной кишки, и в слизистой оболочке тонкого и толстого отделов кишечника, что в целом является неадекватным по отношению к введенной дозе.…”

Section: Table 1 Concentration Of Manganese In Organs and Tissues Of ...unclassified

Role of Manganese in Calcium Metabolism at the Level of the Enteral and Internal Environment of the Body

Ksenofontov,

Voinova,

Ksenofontova

et al. 2023

Тимирязевский биологический журнал

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The authors studied the effect of manganese on calcium metabolism at the level of the enteral and internal environment of the body in an experiment on rabbits. Two groups (control and experimental) of rabbits selected by the paired-analysis method were used in the experiment. There were three animals in each group. The animals in the experimental group were given a diet containing three times the amount of manganese. At the end of the experiment, blood was collected from various parts of the digestive tract of all animals under general anaesthesia. Organs and tissues werecollected for analysis after control slaughter, and the intestines were removed, followed by sampling of chyme and mucosa from the walls of various sections. The chyme was separated into fractions using the developed method. The concentration of manganese and calcium in intestinal chyme and its fractions, in mucosa of the intestinal wall, in the blood flowing in and out of the digestive tract, in organs and tissues was determined by the atomic absorption spectrophotometry method. It was shown experimentally that when the concentration of manganese in the diet of rabbits was tripled, the element was not accumulated in the internal environment but was accumulated by endogenous structures of the chyme and the mucous membrane of the wall of the small and large intestines. A metabolic change in calcium metabolism was revealed when manganese was tripled in the diet: its concentrations in the blood flowing from the intestines and in the mucous layer of the small intestine wall decreased. As a result, there was a significant decrease in bone concentrations and a downward trend in liver and kidney concentrations. The antagonistic effect of manganese on calcium metabolism in the enteric and internal environment is concluded. In the interaction of elements, the leading role of endogenous structures of chyme is noted due to ion-exchange properties of glycoproteins of intestinal cavity mucosa.

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Section: Table 1 Concentration Of Manganese In Organs and Tissues Of ...unclassified

Role of Manganese in Calcium Metabolism at the Level of the Enteral and Internal Environment of the Body

Ksenofontov,

Voinova,

Ksenofontova

et al. 2023

Тимирязевский биологический журнал

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“…Fibroblasts are the largest dermal cells, which contain collagen and elastin, and provide mechanical strength and elasticity to the skin [ 99 , 100 ]. The hypodermis is a deeper level of elastic fibrous tissue with mucous properties, skin cells that store fat, blood vessels, and nerves [ 101 , 102 ]. Traumas such as physical piercing, poisoning, fire, disease, or surgery damage this main organ and lead to the vital organs at risk of infection, injury, or dehydration.…”

Section: Biomedical Applications Of Biopolymeric Composite Materiamentioning

confidence: 99%

Recent Advances in Biopolymeric Composite Materials for Tissue Engineering and Regenerative Medicines: A Review

et al. 2021

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The polymeric composite material with desirable features can be gained by selecting suitable biopolymers with selected additives to get polymer-filler interaction. Several parameters can be modified according to the design requirements, such as chemical structure, degradation kinetics, and biopolymer composites’ mechanical properties. The interfacial interactions between the biopolymer and the nanofiller have substantial control over biopolymer composites’ mechanical characteristics. This review focuses on different applications of biopolymeric composites in controlled drug release, tissue engineering, and wound healing with considerable properties. The biopolymeric composite materials are required with advanced and multifunctional properties in the biomedical field and regenerative medicines with a complete analysis of routine biomaterials with enhanced biomedical engineering characteristics. Several studies in the literature on tissue engineering, drug delivery, and wound dressing have been mentioned. These results need to be reviewed for possible development and analysis, which makes an essential study.

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Nanostructural Mechanism of Modifying Adaptation of Proteoglycan Systems of Biological Tissues and Mucus

Cited by 2 publications

References 10 publications

Role of Manganese in Calcium Metabolism at the Level of the Enteral and Internal Environment of the Body

Role of Manganese in Calcium Metabolism at the Level of the Enteral and Internal Environment of the Body

Recent Advances in Biopolymeric Composite Materials for Tissue Engineering and Regenerative Medicines: A Review

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