Nanostructured materials functionalized with metal complexes: In search of alternatives for administering anticancer metallodrugs

Wani, Waseem A.; Prashar, Sanjiv; Shreaz, Sheikh; Gómez‐Ruiz, Santiago

doi:10.1016/j.ccr.2016.01.001

Cited by 196 publications

(133 citation statements)

References 307 publications

Supporting

Mentioning

130

Contrasting

Order By: Relevance

“…The position of these peaks is influenced by the nitrogen atoms in the aromatic ring. For νPt-N and νPt-Cl, the lowest wavenumbers were found in the case of [Pt(pa) 2 Cl 2 ], which means that these bonds are stronger compared to those in the other complexes.…”

Section: Ft-ir Spectramentioning

confidence: 92%

“…Furthermore, on the DTA curve of 2 a small exothermic peak is observed at 204 °C without significant mass change at this temperature. The thermal decomposition of compound [Pt(aph) 2 Cl 2 ] (3) is followed by an exothermic effect with a small peak at 217 °C due to its oxygen content. The thermal properties of the samples in air are somewhat different from those in nitrogen.…”

Section: Fig 2 Tg and Dtg Curves Of 1 ( ̶ ̶ ̶ ) 2 (---) And 3 (-· -mentioning

confidence: 99%

“…Since the discovery of anticancer activity of cisplatin, high efforts have been made to find more active and less toxic neoplastic agents for cancer treatment in humans [2]. High number of different platinum complexes is synthesized with the aim to understand better the mode of action of platinum based antitumor drugs and to get new ones with fewer side effects.…”

Section: Introductionmentioning

confidence: 99%

“…Since the thermal properties of biological active compounds are crucial for their future application, the other aim of this work is the detailed thermal analysis of the synthesized coordination compounds. Namely, [Pt(an) 2 Cl 2 ] (1), [Pt(pa) 2 Cl 2 ] (2) and [Pt(aph) 2 Cl 2 ] (3) were prepared, where an is 2-aminonaphthalene, pa is 2-pyrimidinamine and aph is 4-anilinophenol. Different synthetic methods and properties of compounds 1 [34] and 2 [35] were published earlier.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

Holló

Szilágyi

Várhelyi

et al. 2016

J Therm Anal Calorim

View full text Add to dashboard Cite

Three complexes of general formula PtCl 2 R 2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an) 2 Cl 2 ] (1), [Pt(pa) 2 Cl 2 ] (2) and [Pt(aph) 2 Cl 2 ] (3), where an is 2-aminonaphtalene, pa is 2-pyrimidinamine and aph is 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI-MS and NMR), and tested against selected Gram(+) and Gram(-) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(−) bacteria.

show abstract

Section: Ft-ir Spectramentioning

confidence: 92%

Section: Fig 2 Tg and Dtg Curves Of 1 ( ̶ ̶ ̶ ) 2 (---) And 3 (-· -mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

Holló

Szilágyi

Várhelyi

et al. 2016

J Therm Anal Calorim

View full text Add to dashboard Cite

show abstract

“…Many of complexes have been found to be active in the restrained reproduction of cancer cells [1][2][3][4][5], and some of them have been used in clinical treatments. Metal complexes with high anticancer activity and non-covalent DNA or protein binding properties have played an important role in antitumor chemotherapy and developed an active research area in metal-based drugs [6]. DNA is the most important target for antitumorals because of its central role in replication and transcription.…”

Section: Introductionmentioning

confidence: 99%

Copper(II) Complexes Based on Aminohydroxamic Acids: Synthesis, Structures, In Vitro Cytotoxicities and DNA/BSA Interactions

Zhang

Yang

et al. 2018

Crystals

View full text Add to dashboard Cite

(4) (glyha 2− = dianion glycinehydroxamic acid, alaha 2− = dianion alaninehydroxamic acid, bpy = 2,2 -bipyridine, phen = 1,10-phenanthroline) have been successfully synthesized and characterized by X-ray single crystal diffraction. The interactions of these complexes with calf thymus DNA (CT-DNA) were studied through UV spectroscopy, fluorescence spectroscopy, and circular dichroism. The results revealed that complexes 1-4 could interact with CT-DNA through intercalation. Interactions of all complexes with bovine serum albumin (BSA) were confirmed by the docking study to quench the intrinsic fluorescence of BSA in a static quenching process. Furthermore, the in vitro cytotoxic effect of the complexes was also examined on four tumor cell lines, including human lung carcinoma cell line (A549), human colon carcinoma cell line (HCT-116), human promyelocytic leukemia cell (HL-60) and cervical cancer cell line (HeLa). All complexes exhibited different antitumor activities.

show abstract

Advancement of Nanoengineered Flavonoids for Chronic Metabolic Diseases

Sharma,

Anand,

Halagali

et al. 2024

Role of Flavonoids in Chronic Metabolic Diseases

View full text Add to dashboard Cite

Nanostructured materials functionalized with metal complexes: In search of alternatives for administering anticancer metallodrugs

Cited by 196 publications

References 307 publications

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

Copper(II) Complexes Based on Aminohydroxamic Acids: Synthesis, Structures, In Vitro Cytotoxicities and DNA/BSA Interactions

Advancement of Nanoengineered Flavonoids for Chronic Metabolic Diseases

Contact Info

Product

Resources

About