Nanostructured Pt(NH₃)₄Cl₂/SiO₂for nanomedicine: catalytic degradation of DNA in cancer cells

Abstract

In vivo suppression of glioblastoma multiforme (GBM) in Wistar rats using silica-shelled biocatalytic Pt(NH3)4Cl2 nanoparticles is reported. These nanoparticles were synthesized by a sol-gel technique and characterized by SEM and HRTEM imaging. We confirmed morphological uniformity (30 nm) and surface acidity of the nanoparticles, respectively, by TEM imaging and FTIR spectral analysis. Interestingly, treatment of Wistar rats intraperitoneally inoculated with C6 cells using the biocatalysts resulted in considerable tumor shrinkage. Efficiency of the biocatalyst to shrink a tumor is superior to that by the commercial cytotoxic agent cisplatin. The tumor suppression property of Pt(NH3)4Cl2 nanoparticles is attributed to catalytic damage of DNA in C6 cells.

Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective

“…These materials showed different adsorption behavior and therapeutic effects against leukaemia, obtaining better results in cell viability than Pt compounds and doxorubicin alone after 24 h of incubation [43]. In addition, T. López et al loaded a cisplatin derivative on small mesoporous silica nanoparticles for studying the catalytic degradation of DNA, observing a tumor suppression attributed to high DNA damage caused by this type of system [44].…”

Reflections on the 2nd International Congress on NanoBioEngineering 2020

“…Her work designed catalytic nanotherapies that suppressed tumors with more efficiency than commercially used cancer treatments. Her talk was inspiring and emphasized the vast avenue of new nano-pharmaceuticals being developed to treat other cancer types (Lopez et al, 2011 ). Next, León-Buitimea et al talked about the role of nanobioengineering in the development of smart therapeutics with programmed dynamic responses to target, release, and clear therapeutics in an efficient manner in the treatment of infectious diseases caused by virus and bacteria (León-Buitimea et al, 2020 ).…”

Avances e implicaciones éticosociales de la nanomedicina: una revisión desde el caso del cáncer cerebral

“…Las investigaciones realizadas en México por López-Goerne y colaboradores (2007,2008, 2010 y 2011) se perfilan en tal dirección. Según sostienen, la inyección de nanopartículas Pt(NH3)4Cl2/SiO2 directamente en el tumor es viable en tanto que las células cancerosas son susceptibles a recibirlas (López-Goerne et al, 2011). La investigación en cuestión se ha realizado en ratas Wistar mostrando, según se indica, resultados positivos, pues se cree que la muerte de células cancerosas deviene de los radicales libres que inducen daño al ADN: el tumor en las ratas enfermas disminuye a los 30 días de la aplicación de entre 50% a 80% (López-Goerne et al, 2011;Peralta, 2012).…”