Nanostructured TiO2 and TiO2-Ag Antimicrobial Thin Films

Prasad, Rajendra; Basavaraju, D.; Rao, K. Narasimha; Naveen, C. S.; Endrino, José L.; Phani, A. R.

doi:10.1109/nstsi.2011.6111808

Cited by 8 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hybrid could also, through the generation of reactive oxygen species (ROS) through its metallic compounds, cause lysis of the bacterium [66]. The production of ROS is presented as a major contributor to the antibacterial activities of various metal oxides [67]. Such reactive species are superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxide (OH-).…”

Section: Resultsmentioning

confidence: 99%

Preparation of the Hybrids of Hydrotalcites and Chitosan by Urea Method and Their Antimicrobial Activities

et al. 2019

View full text Add to dashboard Cite

Hybrid nano-supra molecular structured materials can boost the functionality of nano- or supra-molecular materials by providing increased reactivity and conductivity, or by simply improving their mechanical stability. Herein, the studies in materials science exploring hybrid systems are investigated from the perspective of two important related applications: healthcare and food safety. Interfacing phase strategy was applied, and ZnAl layered double hydroxide-chitosan hybrids, prepared by the urea method (U-LDH/CS), were successfully synthesized under the conditions of different chitosan(CS) concentrations with a Zn/Al molar ratio of 5.0. The structure and surface properties of the U-LDH/CS hybrids were characterized by X-ray diffraction (XRD), Fourier-transform infrared spectrometer(FTIR), scanning electronmicroscopy (SEM), ultravioletvisible (UV-Vis), and zero point charge (ZPC) techniques, where the effect of CS concentration on the structure and surface properties was investigated. The use of the U-LDH/CS hybrids as antimicrobial agents against Escherichia coli, Staphylococcus aureus, and Penicillium cyclopium was investigated in order to clarify the relationship between microstructure and antimicrobial ability. The hybrid prepared in a CS concentration of 1.0 g∙L−1 (U-LDH/CS1) exhibited the best antimicrobial activity and exhibited average inhibition zones of 24.2, 30.4, and 22.3mm against Escherichia coli, Staphylococcus aureus, and Penicillium cyclopium, respectively. The results showed that the appropriate addition of CS molecules could increase antimicrobial ability against microorganisms.

show abstract

Section: Resultsmentioning

confidence: 99%

Preparation of the Hybrids of Hydrotalcites and Chitosan by Urea Method and Their Antimicrobial Activities

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Since aqueous ZnO-NPs suspensions produce significant amounts of ROS, ROS are regarded to be the main cause of nanotoxicity [75,76,77]. Photocatalytic ROS production is primarily responsible for the antimicrobial effects of several metal oxides [78]. Raghupathi and co-workers [79] suggested the strong antibacterial effect of ZnO was due to enhanced ROS generation in the presence of UV light.…”

Section: Antibacterial Mechanisms Of Npsmentioning

confidence: 99%

Mechanistic Insights into the Antimicrobial Actions of Metallic Nanoparticles and Their Implications for Multidrug Resistance

Shaikh

Nazam

Rizvi

et al. 2019

IJMS

363

200

View full text Add to dashboard Cite

Multiple drug-resistant bacteria are a severe and growing public health concern. Because relatively few antibiotics have been approved over recent years and because of the inability of existing antibiotics to combat bacterial infections fully, demand for unconventional biocides is intense. Metallic nanoparticles (NPs) offer a novel potential means of fighting bacteria. Although metallic NPs exert their effects through membrane protein damage, superoxide radicals and the generation of ions that interfere with the cell granules leading to the formation of condensed particles, their antimicrobial potential, and mechanisms of action are still debated. This article discusses the action of metallic NPs as antibacterial agents, their mechanism of action, and their effect on bacterial drug resistance. Based on encouraging data about the antibacterial effects of NP/antibiotic combinations, we propose that this concept be thoroughly researched to identify means of combating drug-resistant bacteria.

show abstract

“…ROS was measured by using an oxidation-sensitive fluorescent probe 2,7-dichloro dihydro fluorescein diacetate (DCFH-DA) [62]. The bacterial cells were harvested from the overnight grown culture by centrifugation at 3000 rpm for 5 min.…”

Section: Estimation Of Reactive Oxygen Speciesmentioning

confidence: 99%

Preparation and Evaluation of the ZnO NP–Ampicillin/Sulbactam Nanoantibiotic: Optimization of Formulation Variables Using RSM Coupled GA Method and Antibacterial Activities

et al. 2019

View full text Add to dashboard Cite

Nanoparticles (NPs) possessing antibacterial activity represent an effective way of overcoming bacterial resistance. In the present work, we report a novel formulation of a nanoantibiotic formed using Ampicillin/sulbactam (Ams) and a zinc oxide nanoparticle (ZnO NP). 'ZnO NP-Ams' nanoantibiotic formulation is optimized using response surface methodology coupled genetic algorithm approach. The optimized formulation of nanoantibiotic (ZnO NP: 49.9 µg/mL; Ams: 33.6 µg/mL; incubation time: 27 h) demonstrated 15% enhanced activity compared to the unoptimized formulation against K. pneumoniae. The reactive oxygen species (ROS) generation was directly proportional to the interaction time of nanoantibiotic and K. pneumoniae after the initial lag phase of 18 h as evident from 2s'-7'-Dichlorodihydrofluorescein diacetate assay. A low minimum inhibitory concentration (6.25 µg/mL) of nanoantibiotic formulation reveals that even a low concentration of nanoantibiotic can prove to be effective against K. pneumoniae. The importance of nanoantibiotic formulation is also evident by the fact that the 100 µg/mL of Ams and 25 µg of ZnO NP was required individually to inhibit the growth of K. pneumonia, whereas only 6.25 µg/mL of optimized nanoantibiotic formulation (ZnO NP and Ams in the ratio of 49.9: 33.6 in µg/mL and conjugation time of 27 h) was needed for the same.

show abstract

Nanostructured TiO2 and TiO2-Ag Antimicrobial Thin Films

Cited by 8 publications

References 9 publications

Preparation of the Hybrids of Hydrotalcites and Chitosan by Urea Method and Their Antimicrobial Activities

Preparation of the Hybrids of Hydrotalcites and Chitosan by Urea Method and Their Antimicrobial Activities

Mechanistic Insights into the Antimicrobial Actions of Metallic Nanoparticles and Their Implications for Multidrug Resistance

Preparation and Evaluation of the ZnO NP–Ampicillin/Sulbactam Nanoantibiotic: Optimization of Formulation Variables Using RSM Coupled GA Method and Antibacterial Activities

Contact Info

Product

Resources

About