Nanostructured wearable electrochemical and biosensor towards healthcare management: a review

Khaleque, M. A.; Hossain, Md. Ikram; Bacchu, M.S.; Aly, Mohamed Aly Saad; Ali, M.R.

doi:10.1039/d3ra03440b

Cited by 15 publications

(2 citation statements)

References 228 publications

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“…Wearable electrochemical biosensor systems enable the sensitive real-time monitoring of human physiological biomarkers and are a popular research focus in this field 101 , 102 . However, wearable electrochemical biosensors to date tend to be focused on monitoring small molecules, such as glucose and lactate 103 .…”

Section: Application Of Electrochemical Protein Sensors In the Detect...mentioning

confidence: 99%

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Guo,

Zhao,

Huang

et al. 2024

Microsyst Nanoeng

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The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor technology. Proteins are extensively used as biological macromolecular markers in disease diagnosis and the analysis of therapeutic effects. Electrochemical protein biosensors have achieved desirable specificity by using the specific antibody–antigen binding principle in immunology. However, the active centers of protein biomarkers are surrounded by a peptide matrix, which hinders charge transfer and results in insufficient sensor sensitivity. Therefore, electrode-modified materials and transducer devices have been designed to increase the sensitivity and improve the practical application prospects of electrochemical protein sensors. In this review, we summarize recent reports of electrochemical biosensors for protein biomarker detection. We highlight the latest research on electrochemical protein biosensors for the detection of cancer, viral infectious diseases, inflammation, and other diseases. The corresponding sensitive materials, transducer structures, and detection principles associated with such biosensors are also addressed generally. Finally, we present an outlook on the use of electrochemical protein biosensors for disease marker detection for the next few years.

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Section: Application Of Electrochemical Protein Sensors In the Detect...mentioning

confidence: 99%

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Guo,

Zhao,

Huang

et al. 2024

Microsyst Nanoeng

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“…Recently, flexible electrochemical sensors and biosensors have been developed for wearable sensing platforms targeting different biological fluids, such as tears, interstitial fluids, urine, breath, and sweat . These can be constructed employing nanostructured materials, which aid in further miniaturization due to their enhanced charge transfer kinetics, high surface-to-volume ratios and facile functionalization, manipulation, and processing. − Most of the examples found in the literature report the integration of metallic nanoparticles (Au, Ag,) and carbon nanomaterials (MWCNT, GO, CNF) within flexible substrates (PET, cotton yarn) as transductors . However, the sensitivity and selectivity of these devices remain below the performance thresholds for clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Palladium-Coated Submicron Electrospun Polymeric Fibers with Immobilized Uricase for Uric Acid Determination in Body Fluids

Leote,

Crisan,

Matei

et al. 2024

ACS Appl. Polym. Mater.

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This work describes the development of a flexible uric acid (UA) biosensor based on palladium-coated submicrometer electrospun poly(methylmethacrylate) (PMMA) fibers metalized with gold and attached to polyethylene terephthalate substrate (Pd/Au/PMMA/PET). The morphological characterization conducted by scanning electron microscopy revealed nanoscale Pd dendritic structures. Electrochemical investigations in the absence and in the presence of redox probes demonstrated that these Pd nanostructures are responsible for a six-fold increase in the electroactive area and enhanced electron transfer kinetics when compared to the gold-coated electrospun fibers. The UA biosensor obtained by immobilizing the uricase enzyme (UrOx) onto the Pd/Au/PMMA/PET electrode surface, allowed UA detection with a sensitivity of 431 μA cm −2 mM −1 and a limit of detection of 12 μM. Investigation of the redox reactions of hydrogen peroxide (a product of the enzymatic oxidation of UA by UrOx) at the Pd/Au/PMMA/PET electrode demonstrated that the working principle of the biosensor is based on the reduction of PdO produced at the electrode surface during the spontaneous reduction of hydrogen peroxide on Pd. This allows a biosensor operating potential of −0.05 V (vs Ag/AgCl) with high selectivity. The UrOx/Pd/Au/PMMA/PET biosensor was applied for UA detection in body fluids (sweat, urine, and blood serum) with recovery values between 98 and 105%, which were validated by high-performance liquid chromatography analysis. The stability of the device was evaluated over a period of 3 months, retaining 78% of the initial sensitivity, and reproducibility with RSD = 4.9% was achieved. The analytical performance of the biosensor under harsh mechanical deformations and at physiological temperatures demonstrated the potential applications of the device to wearable sensing platforms.

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Electrochemical Sensor Applications of Mechanically Alloyed Powders

Ahmed,

Mohamed

2024

Advanced Structured Materials

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Nanostructured wearable electrochemical and biosensor towards healthcare management: a review

Abstract: In recent years, there has been a rapid increase in demand for wearable sensors, particularly these tracking the surroundings, fitness, and health of people.

Cited by 15 publications

References 228 publications

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Palladium-Coated Submicron Electrospun Polymeric Fibers with Immobilized Uricase for Uric Acid Determination in Body Fluids

Electrochemical Sensor Applications of Mechanically Alloyed Powders

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