Nanostructured γ-Fe2O3@Starch-n-Butyl SO3H as New Recyclable Magnetic Catalyst for Promoting Multi-Component Reactions

Shamsi-Sani, Mahnaz; Shirini, Farhad; Mohammadi-Zeydi, Masoud

doi:10.1166/jnn.2019.16489

Cited by 6 publications

(4 citation statements)

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“…For the synthesis of derivatives 140 , catalytic systems were developed in the form of modified Fe 3 O 4 nanoparticles containing: 82 – 87 silica with terminal sulfo groups; 82 L-proline fragments; 83 chitosan structures; 84 starch with n -butylsulfo group; 85 titanium dioxide functionalized with sulfo groups; 86 system Cu@Fe 3 O 4 . 87 …”

Section: Construction Of Pyrimidobenzimidazole Structure By Multicomponent Reactionsmentioning

confidence: 99%

Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use

Fedotov

Русинов

Ulomsky

et al. 2021

Chem Heterocycl Comp

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Nitrogen-containing heterocyclic compounds are the basis of many natural and synthetic biologically active substances. 1 More than two-thirds of the known drugs used in clinical practice contain heterocyclic and, above all, nitrogen-containing fragments within their structure. Over the past decades, the chemistry of aza-heterocycles has received considerable attention due to the wide spectrum of their biological activity and numerous therapeutic applications in medicine.Of nitrogenous heterocycles, azoloazines containing fragments similar to the natural heterocycles purines and pyrimidines are currently of great practical importance. Thus, non-natural nucleosides abacavir, famciclovir, remdesivir are known, which are the products of structural modifications of all the components of the nucleotide exhibiting excellent indicators of antiviral action (Fig. 1). [2][3][4] In addition to the generally accepted nucleoside forms, the azoloazines themselves are relevant in the search for means of combating diseases on a global scale. Nitroazolo- [5,1-c][1,2,4]triazines and nitroazolo [1,5-a]pyrimidines, a new family of antiviral compounds has been found. 5 The

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Section: Construction Of Pyrimidobenzimidazole Structure By Multicomponent Reactionsmentioning

confidence: 99%

Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use

Fedotov

Русинов

Ulomsky

et al. 2021

Chem Heterocycl Comp

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“…The solvent free synthesis of benzimidazo[2,1-b]quinazolin-1(2H)-ones using halogen free catalyst, O-sulfonated poly(vinylpyrrolidonium) hydrogen sulfate ([PVP-SO 3 H]HSO 4 ) was reported by Goli-Jolodar and co-authors. [215] Several other catalytic systems for the construction of benzimidazoloquinazolinone derivatives have been noted; among these are butane-1-sulfonic acid modified starch-coated-Fe 2 O 3 magnetic nanoparticles [γ-Fe 2 O 3 @starch n-butyl SO 3 H] [216] β-cyclodextrin-SO 3 H as a biocompatible and recoverable catalyst in water, [217] keggin-type heteropoly-11-molybdo-1-vanadophosphoric acid supported on Montmorillonite K-10 clay, [218] nanoporous silica NPs in acetonitrile, [219] p-toluenesulfonic acid monohydrate in acetonitrile, [132] nanoporous sodium montmorillonite clay (Na + -MMT) modified with 1-methyl-3-(trimethoxysilylpropyl)-imidazolium hydrogen sulfate (Na + -MMT-[pmim]HSO 4 ), [220] visible light active exfoliated g-C 3 N 4 / Cu 3 TiO 4 as a heterogeneous photocatalyst, [221] chlorotrimethylsilane (TMSCl) in DMF. [222] The one-pot synthesis of benzimidazoquinazolinone scaffolds by multicomponent reaction between 2-aminobenzimidazole, aryl aldehyde, and 1,3-cyclohexadione in choline chloride : glycerol as deep eutectic solvent (DES) was described by Mahire et al (Scheme 52).…”

Section: Reactions Of 2-aminoimidazole and 2-aminobenzimidazolementioning

confidence: 99%

Dihydroazolopyrimidines: Past, Present and Perspectives in Synthesis, Green Chemistry and Drug Discovery

Desenko,

Gorobets,

Lipson

et al. 2023

The Chemical Record

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Dihydroazolopyrimidines are an important class of heterocycles that are isosteric to natural purines and are therefore of great interest primarily as drug‐like molecules. In contrast to the heteroaromatic analogs, synthetic approaches to these compounds were developed much later, and their chemical properties and biological activity have not been studied in detail until recently. In the review, different ways to build dihydroazolopyrimidine systems from different building blocks are described – via the initial formation of a partially hydrogenated pyrimidine ring or an azole ring, as well as a one‐pot assembly of azole and azine fragments. Special attention is given to modern approaches: multicomponent reactions, green chemistry, and the use of non‐classical activation methods. Information on the chemical properties of dihydroazolopyrimidines and the prospects for their use in the design of drugs of various profiles are also summarized in this review.

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“…In the next step, γ-Fe 2 O 3 was coated with starch at room temperature to obtain γ-Fe 2 O 3 @starch 150, followed by reaction with 1,4-butane sultone 151 in dry toluene under reflux conditions to produce γ-Fe 2 O 3 @starch- n -butylSO 3 H 152 nanoparticles ( Scheme 45 ). 71 …”

Section: Synthesis Of Various Magnetic Bio Polymersmentioning

confidence: 99%

“…Then, g-Fe 2 O 3 was synthesized using Fe 3 O 4 at 250 C. In the next step, g-Fe 2 O 3 was coated with starch at room temperature to obtain g-Fe 2 O 3 @starch 150, followed by reaction with 1,4-butane sultone 151 in dry toluene under reux conditions to produce g-Fe 2 O 3 @starch-n-butylSO 3 H 152 nanoparticles (Scheme 45). 71 g-Fe 2 O 3 @starch-n-butylSO 3 H 152 as Brønsted acid activated the carbonyl groups in the multicomponent reactions of Subsequently, Fe 3 O 4 @Alg@CPTMS@Arg, which has two acidic and basic functional sites, activated the carbonyl groups in the synthesis of 2,4,5-triarylimidazoles through the reaction of ammonium acetate, aldehydes, and benzil in EtOH under reux conditions (Scheme 48). The recyclability of the catalyst was tested 7 times using the model reaction without loss in any of its activities.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the application of magnetic bio-polymers as catalysts in multicomponent reactions

et al. 2022

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Nanostructured γ-Fe₂O₃@Starch-n-Butyl SO₃H as New Recyclable Magnetic Catalyst for Promoting Multi-Component Reactions

Cited by 6 publications

References 0 publications

Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use

Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use

Dihydroazolopyrimidines: Past, Present and Perspectives in Synthesis, Green Chemistry and Drug Discovery

Recent advances in the application of magnetic bio-polymers as catalysts in multicomponent reactions

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